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Results of fluorouracil-augmented Xen45 implantation in primary open-angle and pseudoexfoliation glaucoma

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Abstract

Purpose

To report the effectiveness and safety of 5-fluorouracil (5-FU)-augmented Xen45 implantation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG).

Methods

This single-center, retrospective chart review study included 29 eyes that underwent 5-FU-augmented Xen45 implantation. Main outcome measures were intraocular pressure (IOP) levels and number of glaucoma medications. Surgical success was defined as IOP ≤ 21 mmHg and ≥ 20% reduction from preoperative levels without (complete success) or with (qualified success) glaucoma medications and without further glaucoma surgery at last follow-up. All postoperative interventions and complications were also noted.

Results

The mean age of the patients was 67.5 ± 10.3 years, and the mean follow-up time was 23.2 ± 12.6 months. Mean IOP was 24.5 ± 8.7 mmHg and decreased by 30.2% at 12 months, 24.9% at 24 months, and 31.7% at final visit (p < 0.001, p = 0.006, p > 0.001, respectively). Mean number of glaucoma medications decreased from 2.83 preoperatively to 0.71 at 12 months, 0.87 at 24 months, and 0.86 at final visit (p < 0.001). At final visit, the complete success rate was 48.3%, qualified success rate was 69%, and 62.1% of the eyes were free of glaucoma medications. Needling was performed in 7 eyes (24%). Adverse events included choroidal detachment in 5 eyes, hyphema in 2 eyes, and endophthalmitis in 1 eye.

Conclusion

5-FU-augmented Xen45 implantation in POAG and PEXG patients provided safe and effective IOP lowering with significant reduction of glaucoma medications up to 3 years.

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Authors and Affiliations

  1. Department of Ophthalmology, Karşıyaka Eye Hospital, Caher Dudayev Bulv. No:71, 35550, İzmir, Turkey

    Esin Fatma Başer & Recep Göktuğ Seymenoğlu

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  1. Esin Fatma Başer
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  2. Recep Göktuğ Seymenoğlu
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Correspondence to Esin Fatma Başer.

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Written informed consent was obtained from all patients, and the study was conducted in accordance with the tenets of Declaration of Helsinki and its later amendments or comparable ethical standards.

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Başer, E.F., Seymenoğlu, R.G. Results of fluorouracil-augmented Xen45 implantation in primary open-angle and pseudoexfoliation glaucoma. Int Ophthalmol 41, 945–955 (2021). https://doi.org/10.1007/s10792-020-01650-8

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