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Clinical application of ultra-widefield fundus autofluorescence

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Abstract

Purpose

To review the basic principles of ultra-widefield fundus autofluorescence (UWF-FAF) and discuss its clinical application for a variety of retinal and choroidal disorders.

Methods

A systematic review of the PubMed database was performed using the search terms “ultra-widefield,” “autofluorescence,” “retinal disease” and “choroidal disease.”

Results

UWF-FAF imaging is a recently developed noninvasive retinal imaging modality with a wide imaging range that can locate peripheral fundus lesions that traditional fundus autofluorescence cannot. Multiple commercially available ultra-widefield imaging systems, including Heidelberg Spectralis and Optomap Ultra-Widefield systems, are available to the clinician. Imaging by UWF-FAF is more comprehensive; it can reflect the content and distribution of the predominant ocular fluorophore in retinal pigment epithelial cells and evaluate the metabolic status of RPE of various retinal and choroidal disorders.

Conclusion

UWF-FAF can detect abnormalities that traditional fundus autofluorescence cannot; therefore, it can be used to better elucidate disease pathogenesis, analyze genotype–phenotype correlations, diagnose and monitor disease.

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Acknowledgements

We would like to thank Dr. Schwartz SD, Dr. SriniVas R. Sadda, and Dr. Panagiotis Salvanos for their contributions to the photographs shown in this paper, and Dr. Michael A. Klufas for providing the data shown in the table.

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  1. Department of Ophthalmology of Renmin Hospital of Wuhan University, No238, Jiefang Road, Wuhan, 430060, Hubei, China

    Amin Xu & Changzheng Chen

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Correspondence to Changzheng Chen.

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Xu, A., Chen, C. Clinical application of ultra-widefield fundus autofluorescence. Int Ophthalmol 41, 727–741 (2021). https://doi.org/10.1007/s10792-020-01609-9

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