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Inner retinal layers’ alterations and microvasculature changes after vitrectomy for rhegmatogenous retinal detachment

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Abstract

Purpose

To examine the retinal layers’ changes and alterations in retinal microvasculature in patients with rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV).

Methods

Participants in this study were 103 patients with RRD, 85 macula off and 18 macula on, who were treated with PPV and gas tamponade without internal limiting membrane peeling, in two centers. All participants underwent best corrected visual acuity measurement, slit-lamp examination, fundoscopy, spectral domain-optical coherence tomography and optical coherence tomography angiography at week 5 and at month 6 postoperatively. The fellow untreated eyes were also examined and served as control data.

Results

A statistically significant enlargement in foveal avascular zone (FAZ) in both superficial capillary plexus (SCP) and deep capillary plexus (DCP) was noticed 5 weeks postoperatively in patients with RRD treated with PPV compared to the fellow eyes and remained 6 months after surgery. The FAZ enlargement in the operated eyes was accompanied with a statistically significant thinning of the inner retinal layer. In addition, there was a significant decrease in foveal and parafoveal vessel density (VD) in both SCP and DCP in the operated eyes compared to control eyes at week 5 postoperatively, which also remained at postoperative month 6.

Conclusions

The study demonstrated that patients with RRD treated with PPV presented changes in the retinal microvasculature in both SCP and DCP, including enlargement of FAZ and decrease in VD. These changes seemed to be associated with inner retinal layer thinning.

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Funding

No funding was received for this research.

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Authors and Affiliations

  1. 2nd Department of Ophthalmology, University of Athens, 28, Papanastasiou Street, Alimos, 17342, Athens, Greece

    Irini Chatziralli, George Theodossiadis, Eleni Dimitriou & Panagiotis Theodossiadis

  2. 2nd Department of Ophthalmology, Ophthalmiatrion Athinon, Athens, Greece

    Efstratios Parikakis & Alexandros Chatzirallis

Authors
  1. Irini Chatziralli
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  2. George Theodossiadis
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  3. Efstratios Parikakis
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  4. Alexandros Chatzirallis
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  5. Eleni Dimitriou
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  6. Panagiotis Theodossiadis
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Contributions

IC collected data, made the statistical analysis, interpreted data and drafted the manuscript. GT conceived the study and drafted the manuscript. EP, AC and ED collected data. PT collected data and supervised the study. All authors have read, critically revised and approved the current version of the manuscript.

Corresponding author

Correspondence to Irini Chatziralli.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, or other equity interest), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Institutional Review Board of the participating hospitals.

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Informed consent was obtained from all individual participants included in the study.

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Chatziralli, I., Theodossiadis, G., Parikakis, E. et al. Inner retinal layers’ alterations and microvasculature changes after vitrectomy for rhegmatogenous retinal detachment. Int Ophthalmol 40, 3349–3356 (2020). https://doi.org/10.1007/s10792-020-01521-2

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  • DOI: https://doi.org/10.1007/s10792-020-01521-2

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