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Assessment of Doppler flow parameters of the retrobulbar arteries and internal carotid artery in patients with glaucoma: the significance of ophthalmic artery peak ratio and the intima–media thickness of the internal carotid artery

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Abstract

Purpose

The objective of this study was to analyze flow parameters of the central retinal artery (CRA), ophthalmic artery (OA), and internal carotid artery (ICA) assessed by color Doppler ultrasound.

Methods

Thirty-five patients with primary open-angle glaucoma (PAAG), 65 patients with normal-tension glaucoma (NTG), and 45 healthy controls, a total of 145 patients were included in this study and study participants were divided into three groups. All study participants underwent color Doppler ultrasound to assess blood flow parameters of CRA, OA and ICA.

Results

Comparisons among three groups revealed that pulsatility index and resistive index of the OA were significantly higher and peak ratio and end-systolic volume were significantly lower in patients with NTG or PAAG compared to healthy controls (p < 0.001 for all). As with OA, resistive index of the CRA was statistically significantly higher in patients with glaucoma (PAAG and NTG) compared to healthy controls (p < 0.001). The peak systolic volume and intima–media thickness of the ICA were statistically significantly higher in patients with PAAG compared to the other two groups (p < 0.001). ROC curve analysis of the CRA resistive index, OA resistive index and OA peak ratio in patients with glaucoma (PAAG and NTG) revealed that the sensitivity and specificity were 89% and 88%; 86% and 84%; 84% and 82%, respectively, at cutoff values of 0.64, 0.78 and 0.59, respectively.

Conclusions

Ophthalmic artery peak ratio and ICA intima–media thickness may be useful parameters in the diagnosis of patients with glaucoma.

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References

  1. Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S (2017) Glaucoma. Lancet 390:2183–2193

    PubMed  Google Scholar 

  2. Flaxman SR, Bourne RRA, Resnikoff S et al (2017) Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. Lancet Glob Heal 5:e1221–e1234

    Google Scholar 

  3. Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121:2081–2090

    PubMed  Google Scholar 

  4. Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard J-P, Stefánsson E (2002) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 21:359–393

    PubMed  Google Scholar 

  5. Stalmans I, Harris A, Fieuws S, Zeyen T, Vanbellinghen V, McCranor L, Siesky B (2009) Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes. Eur J Ophthalmol 19:580–587

    PubMed  Google Scholar 

  6. Abegão Pinto L, Willekens K, Van Keer K, Shibesh A, Molenberghs G, Vandewalle E, Stalmans I (2016) Ocular blood flow in glaucoma—the Leuven Eye Study. Acta Ophthalmol 94:592–598

    PubMed  Google Scholar 

  7. Michelson G, Groh MJ, Groh ME, Gründler A (1995) Advanced primary open-angle glaucoma is associated with decreased ophthalmic artery blood-flow velocity. Ger J Ophthalmol 4:21–24

    CAS  PubMed  Google Scholar 

  8. Gurgel Alves JA, Maia e Holanda Moura SB, Araujo Júnior E, Tonni G, Martins WP, Da Silva Costa F (2016) Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery Doppler indices. J Matern Neonatal Med 29:1190–1194

    Google Scholar 

  9. Chaves MTP, Martins-Costa S, da Oppermann MLR, Dias RP, Magno V, Peña JA, Ramos JGL (2017) Maternal ophthalmic artery Doppler ultrasonography in preeclampsia and pregnancy outcomes. Pregn Hypertens 10:242–246

    Google Scholar 

  10. de Oliveira CA, de Sá RAM, Velarde LGC, da Silva FC, do Vale FA, Netto HC (2013) Changes in ophthalmic artery doppler indices in hypertensive disorders during pregnancy. J Ultrasound Med 32:609–619

    PubMed  Google Scholar 

  11. Takata M, Nakatsuka M, Kudo T (2002) Differential blood flow in uterine, ophthalmic, and brachial arteries of preeclamptic women. Obstet Gynecol 100:931–939

    PubMed  Google Scholar 

  12. Scoutt LM, Gunabushanam G (2019) Carotid ultrasound. Radiol Clin North Am 57:501–518

    PubMed  Google Scholar 

  13. Pinto LA, Vandewalle E, de Clerck E, Marques-Neves C, Stalmans I (2012) Ophthalmic Artery Doppler waveform changes associated with increased damage in glaucoma patients. Investig Ophthalmol Vis Sci 53:2448–2453

    Google Scholar 

  14. Stalmans I, Vandewalle E, Anderson DR et al (2011) Use of colour Doppler imaging in ocular blood flow research. Acta Ophthalmol 89:e609–e630

    PubMed  Google Scholar 

  15. Nakatsuka M, Takata M, Tada K, Kudo T (2002) Effect of a nitric oxide donor on the ophthalmic artery flow velocity waveform in preeclamptic women. J Ultrasound Med 21:309–313

    PubMed  Google Scholar 

  16. Bonomi L (2000) Vascular risk factors for primary open angle glaucoma :The Egna-Neumarkt study. Ophthalmology 107:1287–1293

    CAS  PubMed  Google Scholar 

  17. Leske MC, Heijl A, Hyman L, Bengtsson B, Dong L, Yang Z (2007) Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology 114:1965–1972

    PubMed  Google Scholar 

  18. Heijl A (2002) Reduction of intraocular pressure and glaucoma progression. Arch Ophthalmol 120:1268

    PubMed  Google Scholar 

  19. Dienstbier E, Balik J, Kafka H (1950) A contribution to the theory of the vascular origin of glaucoma. Br J Ophthalmol 34:47–58

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Xu S, Huang S, Lin Z, Liu W, Zhong Y (2015) Color Doppler imaging analysis of ocular blood flow velocities in normal tension glaucoma patients: a meta-analysis. J Ophthalmol 2015:1–24

    CAS  Google Scholar 

  21. Leske MC, Wu S-Y, Hennis A, Honkanen R, Nemesure B (2008) Risk factors for incident open-angle glaucoma. Ophthalmology 115:85–93

    PubMed  Google Scholar 

  22. Quigley HA (2001) The prevalence of glaucoma in a population-based study of hispanic subjects. Arch Ophthalmol 119:1819

    CAS  PubMed  Google Scholar 

  23. Cherecheanu AP, Garhofer G, Schmidl D, Werkmeister R, Schmetterer L (2013) Ocular perfusion pressure and ocular blood flow in glaucoma. Curr Opin Pharmacol 13:36–42

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Kocaturk T, Isikligil I, Uz B, Dayanir V, Dayanir YO (2016) Ophthalmic artery blood flow parameters in pseudoexfoliation glaucoma. Eur J Ophthalmol 26:124–127

    PubMed  Google Scholar 

  25. Akcar N, Yıldırım N, Adapınar B, Kaya T, Ozkan IR (2005) Duplex sonography of retro-orbital and carotid arteries in patients with normal-tension glaucoma. J Clin Ultrasound 33:270–276

    PubMed  Google Scholar 

  26. Sharma N, Bangiya D (2006) Comparative study of ocular blood flow parameters by color doppler imaging in healthy and glaucomatous eye. Indian J Radiol Imaging 16:679

    Google Scholar 

  27. de Oliveira CA, de Sá RAM, Velarde LGC, Marchiori E, Netto HC, Ville Y (2009) Doppler velocimetry of the ophthalmic artery in normal pregnancy. J Ultrasound Med 28:563–569

    PubMed  Google Scholar 

  28. Adeyinka OO, Olugbenga A, Helen OO, Adebayo AV, Rasheed A (2013) Ocular blood flow velocity in primary open angle glaucoma—a tropical african population study. Middle East Afr J Ophthalmol 20:174–178

    PubMed  PubMed Central  Google Scholar 

  29. American Diabetes Association (2014) Diagnosis and classification of diabetes mellitus. Diab Care 37: S81–S90

  30. Unay M, Küçükgül S, Yararcan M, Öziz EÇZ (2000) Assesment of orbital arteries blood flow rate with coloured doppler ultrasonography in primary open angle glaucoma. Turk J Ophthalmol 30:417–422

    Google Scholar 

  31. Conti M, Prevedello DM, Madhok R, Faure A, Ricci UM, Schwarz A, Robert R, Kassam AB (2008) The antero-medial triangle: the risk for cranial nerves ischemia at the cavernous sinus lateral wall. Anatomic cadaveric study. Clin Neurol Neurosurg 110:682–686

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Somalia Mogadishu—Turkey Education and Research Hospital ethical review committee (Date: December 26,2019, Decision No. 198, No. MSTH/2901).

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Authors and Affiliations

  1. Department of Ophthalmology, Somalia Mogadishu—Turkey Education and Research Hospital, Mogadishu, Somalia

    Mustafa Kalayci

  2. Department of Ophthalmology, Antalya Training and Research Hospital, Antalya, Turkey

    Mustafa Kalayci

  3. Department of Radiology, Somalia Mogadishu—Turkey Education and Research Hospital, Mogadishu, Somalia

    Mehmet Tahtabasi

  4. Department of Radiology, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey

    Mehmet Tahtabasi

Authors
  1. Mustafa Kalayci
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  2. Mehmet Tahtabasi
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All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.

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Correspondence to Mustafa Kalayci.

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Written informed consent was obtained from the patients before any examination or treatment was performed.

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Kalayci, M., Tahtabasi, M. Assessment of Doppler flow parameters of the retrobulbar arteries and internal carotid artery in patients with glaucoma: the significance of ophthalmic artery peak ratio and the intima–media thickness of the internal carotid artery. Int Ophthalmol 40, 3337–3348 (2020). https://doi.org/10.1007/s10792-020-01520-3

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  • DOI: https://doi.org/10.1007/s10792-020-01520-3

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