Quantitative evaluation of retinal microvascular circulation in patients with obstructive sleep apnea–hypopnea using optical coherence tomography angiography

Abstract

Purpose

To compare capillaries perfusion in macular areas at different layers and peripapillary region in radial peripapillary capillaries (RPC) between healthy subjects and subjects with obstructive sleep apnea–hypopnea (OSA) using spectral-domain optical coherence tomography angiography (OCTA).

Methods

Totally 16 eyes with mild-to-moderate OSA, 14 eyes with severe OSA and 22 control eyes were enrolled in this study. Every subject filled out the Berlin questionnaire and received a comprehensive ocular and physical examination. The clinical characteristics were collected, OCT and OCTA scans using OCTA RT XR Avanti (AngioVue software, Optovue Inc., Fremont, CA, USA) were performed and analyzed.

Results

Compared to the control group, the severe group had significantly higher VD in parafovea and perifoveal regions (p = 0.031; p = 0.029) at the level of deep capillary plexus (DCP), whereas the mild-to-moderate group had a significantly lower VD in the peripapillary region on RPC network in disc areas (p = 0.013).

Conclusions

Blood flow changes in macular areas might first appear at the DCP layer in OSA patients. Reduced VD in the peripapillary region at the RPC layer might be associated with OSA and cause subsequent RNFL changes.

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Fig. 1

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Acknowledgements

The authors are grateful to all the patients who participated in this study.

Funding

This study was supported by the National Natural Science Foundation of China (Grant No. 81970815).

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Authors

Contributions

XS and FH designed this study. XS, GSS, and YC defined the criteria for inclusion and exclusion. LZ, GSS, and YC performed examinations. LZ and YC analyzed and interpreted the patient data. YC drafted this manuscript and made the figures and tables. XS, FH, and MWZ modified the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Xuan Shi.

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Conflict of interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Availability of data and materials

The data supporting this study are available upon request from Prof. Xuan Shi (e-mail: drxuanshi@163.com).

Ethics approval and consent to participate

This study adhered to the tenets of the Declaration of Helsinki and was approved by the Ethics Committee of People’s Hospital of Peking University. Informed consent was obtained from all individual participants included in the study.

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Cite this article

Cai, Y., Sun, G., Zhao, L. et al. Quantitative evaluation of retinal microvascular circulation in patients with obstructive sleep apnea–hypopnea using optical coherence tomography angiography. Int Ophthalmol (2020). https://doi.org/10.1007/s10792-020-01518-x

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Keywords

  • Deep capillary plexus
  • Optical coherence tomography angiography
  • Obstructive sleep apnea–hypopnea
  • Retinal nerve fiber layer
  • Radial peripapillary capillary
  • Vessel density