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Subclinical inner retinal layer thickness changes in the fellow eyes of patients with unilateral central retinal artery occlusion: a pilot study

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Abstract

Purpose

To investigate microstructural changes in the macular inner retinal layers over time in the fellow eyes of patients with unilateral central retinal artery occlusion (CRAO).

Methods

Spectral-domain optical coherence tomography scans of 16 patients with CRAO were performed at initial examination (1st day), at 1st month, at 3rd month, at 6th month, and the central macular thickness (CMT) and inner retinal layer thicknesses in the fellow eyes of the patients were compared between each visit. The thicknesses of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer (INL) were calculated in 9 quadrants according to the definition by the Early Treatment Diabetic Retinopathy Study.

Results

CMT decreased over a 6-month period, but the difference was insignificant among visits (p = 0.072). Also, there were no significant differences in the thicknesses of RNFL and GCL among visits (p > 0.05 for all quadrants). But there was thinning in the parafoveal superior and perifoveal superior quadrants of the IPL (p = 0.007, p = 0.01) and in the parafoveal temporal quadrant of the INL (p = 0.033) within 6 months of follow-up in the fellow eyes of the patients with CRAO.

Conclusion

This study demonstrated subclinical alterations of the macular inner retinal layers over time in the fellow eyes of CRAO patients.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

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Authors and Affiliations

  1. Meram Faculty of Medicine, Department of Ophthalmology, Necmettin Erbakan University, 42080, Meram, Konya, Turkey

    Enver Mirza, Gunsu Deniz Mirza, Refik Oltulu, Selman Belviranli & Hurkan Kerimoglu

Authors
  1. Enver Mirza
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  2. Gunsu Deniz Mirza
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  3. Refik Oltulu
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  4. Selman Belviranli
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  5. Hurkan Kerimoglu
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Contributions

EM contributed to concept and design and drafted the manuscript, EM and GDM were involved in data acquisition and data analysis/interpretation, EM, GDM, and RO contributed to statistical analysis, and EM, GDM, RO, SB, and HK were involved in critical revision of manuscript and supervision. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Enver Mirza.

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Conflict of interest

The authors declare that they have no competing interests.

Ethics approval

The Necmettin Erbakan University Ethics Committee approved this is a retrospective study as an audit study and gave it the following reference number: 2020/2263.

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Mirza, E., Mirza, G.D., Oltulu, R. et al. Subclinical inner retinal layer thickness changes in the fellow eyes of patients with unilateral central retinal artery occlusion: a pilot study. Int Ophthalmol 40, 2979–2986 (2020). https://doi.org/10.1007/s10792-020-01481-7

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  • DOI: https://doi.org/10.1007/s10792-020-01481-7

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