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Evaluation of emulsified silicone oil with spectral domain-optical coherence tomography and fluorescein angiography

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Abstract

Background

To report emulsified particles and related complications after removal of silicone oil (SO) by spectral domain-optical coherence tomography (SD-OCT) and fluorescein angiography (FA).

Methods

A prospective, single-center investigation was performed using SD-OCT, FA and flare cell photometry measurements to evaluate in a cohort of eyes with emulsified silicone particles after removal of long-term SO tamponade.

Results

Nineteen eyes of the 19 patients with emulsified silicone particles detected in ophthalmoscopic exam were included in the study: 13 (68%) were male, and 6 (31.6%) were female, and their mean age was 52.75 ± 16.06 years. Preoperative diagnoses were rhegmatogenous retinal detachment in all eyes. The mean duration of the silicone oil’s presence in the eye was found as 12.63 ± 4.87 (7–26) months. SD-OCT examination postoperatively showed small, round and hyper-reflective structures compatible with emulsified silicone particles on preretinal surface in 7 (36.8%) eyes, intraretinally in 6 (31.6%) eyes and in the vitreous in 12 (63%) eyes. FA imaging demonstrated pearl-like hyper-fluorescence at early and late phases on the large blood vessels in 9 (47.4%) eyes. Late phase hyper-fluorescence due to leakage on the macula was observed in 17 (89.5%) eyes. Diffuse peripheral leakage and hyper-fluorescence was detected in 11 (57.9%) eyes. Flare levels were higher in eyes with emulsified SO compared to unaffected fellow eyes (p < 0.05).

Conclusions

Emulsified silicone particles that remain in the eye may lead to retinal complications and inflammation in addition to their known complications such as keratopathy and glaucoma. The particles that lead to inflammation and presence of inflammation may be examined by imaging methods such as SD-OCT and FA. Removing the SO before emulsification would be suitable for avoiding such complications.

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Funding

This study was not funded by any company.

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Authors and Affiliations

  1. Ophthalmology Department, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Zafer Cebeci, Muhammed Talha Sadik, Mehmet Bedii Ogurel, Emre Altinkurt & Nur Kir

  2. I.U. Istanbul Tip Fakultesi Göz Hastalikları AD Capa, Fatih, Istanbul, Turkey

    Zafer Cebeci

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  1. Zafer Cebeci
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  2. Muhammed Talha Sadik
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  3. Mehmet Bedii Ogurel
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  4. Emre Altinkurt
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  5. Nur Kir
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Correspondence to Zafer Cebeci.

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All authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Written informed consent was obtained from the parents of each subject in the study.

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Cebeci, Z., Sadik, M.T., Ogurel, M.B. et al. Evaluation of emulsified silicone oil with spectral domain-optical coherence tomography and fluorescein angiography. Int Ophthalmol 40, 2267–2274 (2020). https://doi.org/10.1007/s10792-020-01409-1

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  • DOI: https://doi.org/10.1007/s10792-020-01409-1

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