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Diurnal fluctuations of macular vessel density in patients with primary open-angle glaucoma and healthy subjects

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Abstract

Purpose

To investigate the diurnal fluctuations of macular vessel density (VD) in primary open-angle glaucoma (POAG) and healthy subjects using optical coherence tomography angiography.

Methods

A total of 22 POAG eyes and 15 healthy eyes were included in this study. Macular VD, intraocular pressure, and blood pressure were repeatedly measured from 8 AM to 8 PM at a 2-h interval on a single day. Main outcome measures: the macular VD measurements, their diurnal fluctuations, including the difference between their maximal and minimal value (max–min) and their coefficient of variation (CV) in superficial capillary plexus (SCP) and deep capillary plexus (DCP). The mixed-effects model was performed to compare the fluctuations between groups.

Results

After adjusted age, the diurnal fluctuations of macular VD in SCP and DCP were significantly higher in POAG eyes compared with healthy subjects (max–min: 6.65 ± 3.54%, 3.92 ± 3.63%, respectively; p = 0.037 and CV: 0.06 ± 0.03, 0.04 ± 0.03, respectively; p = 0.003). The fovea VD in DCP of POAG eyes was higher than in healthy subjects (31.52 ± 4.68% and 25.71 ± 3.70%, p = 0.009). However, there was no significant difference between the fovea VD in SCP in two groups (20.97 ± 4.75% and 19.29 ± 4.35%, p = 0.670). The diurnal macular superficial VD measured in most of the participants was lower in the morning.

Conclusions

Whether it is a max–min or a CV assessment method, the POAG eyes had more significant diurnal fluctuations of macular VD than healthy controls, suggesting impaired vascular autoregulation in POAG eyes.

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Funding

This study was funded by Zhejiang Province Health Innovation Talents Project (Grant Number ZJCX-PT-201601).

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Authors and Affiliations

  1. The Eye hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, China

    Xiaojie Wang, Shaodan Zhang, Xiao Shang, Kun Zhou, Yuan Lan & Yuanbo Liang

  2. The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, China

    Juanjuan Chen & Jianqiu Cai

Authors
  1. Xiaojie Wang
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  2. Juanjuan Chen
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  3. Shaodan Zhang
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  4. Xiao Shang
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  5. Kun Zhou
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  6. Yuan Lan
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  7. Jianqiu Cai
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  8. Yuanbo Liang
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Corresponding author

Correspondence to Yuanbo Liang.

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Conflict of interest

Xiaojie Wang, Juanjuan Chen, Shaodan Zhang, Xiao Shang, Kun Zhou, Yuan Lan, Jianqiu Cai, and Yuanbo Liang declares that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Wang, X., Chen, J., Zhang, S. et al. Diurnal fluctuations of macular vessel density in patients with primary open-angle glaucoma and healthy subjects. Int Ophthalmol 40, 2257–2266 (2020). https://doi.org/10.1007/s10792-020-01408-2

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  • DOI: https://doi.org/10.1007/s10792-020-01408-2

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