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Ciliary muscle dimensions measured by swept-source optical coherence tomography in eyes with primary open-angle glaucoma and healthy eyes

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Abstract

Purpose

To compare in vivo swept-source optical coherence tomography (SS-OCT) measurements of the ciliary muscle (CM) in patients with primary open-angle glaucoma (POAG) and healthy subjects, and examine correlations between CM dimensions and several covariates.

Methods

This was a cross-sectional study of the right eyes of 181 subjects: 89 POAG patients and 92 healthy subjects. Using the Triton SS-OCT device (Topcon, Tokyo, Japan), CM length (CML), area (CMA) and thickness measured 1000 µm (CMT1), 2000 µm (CMT2) and 3000 µm (CMT3) from the scleral spur were determined in the temporal and nasal quadrants. POAG patients were subjected to visual field (VF) and peripapillary retinal nerve fiber layer (RNFL) assessment. CM dimensions were then assessed for correlation with VF mean defect (MD), mean RNFL thickness and intraocular pressure (IOP).

Results

Mean CMLs were 4325 ± 340 µm and 4195 ± 843 µm for the healthy subjects and POAG patients, respectively (p = 0.17). Mean CM thicknesses were CMT1 = 546 ± 56 µm, CMT2 = 326 ± 44 µm and CMT3 = 174 ± 16 µm in the healthy eyes versus CMT1 = 534 ± 108, CMT2 = 332 ± 99 and CMT3 = 183 ± 74 in the POAG eyes, with no significant differences detected (all p ≥ 0.25). In the temporal quadrant, mean CMA was 1.12 ± 0.29 mm2 and 1.15 ± 0.24 mm2 for the healthy and POAG subjects, respectively (p = 0.45). No correlations were observed between CM measurements and RNFL thickness (p ≥ 0.15), IOP or VF MD (p ≥ 0.14) in POAG subjects irrespective of glaucoma severity (p ≥ 0.19).

Conclusions

While SS-OCT proved useful to measure CM dimensions in vivo, these dimensions did not differ between healthy individuals and POAG subjects. In the patients with POAG, no correlations were detected between CM dimensions and VF, RNFL or IOP.

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Authors and Affiliations

  1. Department of Ophthalmology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain

    Bachar Kudsieh & José María Ruiz-Moreno

  2. Centro Internacional de Oftalmología Avanzada, Zurbano 71, 28010, Madrid, Spain

    Bachar Kudsieh, José Ignacio Fernández-Vigo, Hang Shi & José Ángel Fernández-Vigo

  3. Department of Ophthalmology, San Carlos Clinical Hospital, Health Research Institute (IdISSC), Universidad Complutense, OFTARED, Madrid, Spain

    José Ignacio Fernández-Vigo, Hang Shi & Julián García-Feijóo

  4. Department of Ophthalmology, Hospital Universitario Doce De Octubre, Madrid, Spain

    Lucía De Pablo Gómez de Liaño

  5. Department of Ophthalmology, Universidad de Extremadura, Badajoz, Spain

    José Ángel Fernández-Vigo

Authors
  1. Bachar Kudsieh
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  2. José Ignacio Fernández-Vigo
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  3. Hang Shi
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  4. Lucía De Pablo Gómez de Liaño
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  6. Julián García-Feijóo
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  7. José Ángel Fernández-Vigo
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Correspondence to Bachar Kudsieh.

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Kudsieh, B., Fernández-Vigo, J.I., Shi, H. et al. Ciliary muscle dimensions measured by swept-source optical coherence tomography in eyes with primary open-angle glaucoma and healthy eyes. Int Ophthalmol 40, 2247–2255 (2020). https://doi.org/10.1007/s10792-020-01405-5

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  • DOI: https://doi.org/10.1007/s10792-020-01405-5

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