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Comparison of two intense pulsed light patterns for treating patients with meibomian gland dysfunction

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Abstract

Purpose

The objective of this was to determine the efficacy of different patterns of intense pulsed light (IPL) therapy in patients with meibomian gland dysfunction (MGD).

Materials and method

IPL treatment was administered in 124 eyes of 62 patients with MGD-associated dry eye disease (DED). These patients were divided randomly into two groups treated with different IPL patterns. The first group was treated with “Optimal Pulse Technology” (OPT) (n = 29) and received three consecutive treatments (10–14 J/cm2) with three weeks between treatments. The other group was treated with “Intense Regulated Pulsed Light” (IRPL) (n = 33) and received four treatments (9–13 J/cm2) on days (D)1, D15, D45, and D75. The Ocular Surface Disease Index (OSDI), fluorescein breakup time (FTBUT), first and the average of noninvasive keratograph tear breakup times (NIKBUT), Schirmer I tests, conjunctival hyperemia, corneal fluorescent staining (CFS), tear meniscus height (TMH), MG secretion, and dropout were examined before each treatment and at one and three months after treatment.

Results

Compared to baseline, the clinical symptoms and signs in both groups were significantly improved at one and three months after IPL treatment. However, compared to the IRPL group, the OPT-treated group showed significant improvement in the clarity of MG secretions (P = 0.001), the number of MGs yielding clear or cloudy liquid secretions (P < 0.001), the total MG secretion score (P < 0.001) in lower eyelid, the lid margin score in upper (P < 0.001) and lower eyelids (P = 0.013), the first NIKBUT (P = 0.009), and FTBUT (P = 0.006).

Conclusions

These results suggest that IPL has significant clinical value in treating patients with MGD. OPT IPL treatment was more effective in improving MG function in lower eyelids and partial tear film signs than IRPL IPL treatment.

Trial Registration

The study was registered at www.clinicaltrials.gov, and the clinical trial accession number is NCT02481167.

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Data availability

All data used to support the findings of this study were included within the article.

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Acknowledgements

The authors would like to thank Dr. Terry G. Coursey for editing the manuscript. This manuscript was presented as a poster (No. PO-0353) at the 23rd congress of Chinese Ophthalmological Society, Hangzhou, China, in September 2018.

Funding

This study was supported by the Public Welfare Project of Wenzhou Science and Technology Bureau (No. Y20160447; Y20160454).

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Author notes

  1. Yue Wu and Junhua Li these authors have contributed equally to this work.

Authors and Affiliations

  1. School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, 270 West Xueyuan Road, Wenzhou, 325027, Zhejiang, China

    Yue Wu, Junhua Li, Man Hu, Yinying Zhao, Xiaolei Lin, Yiqin Chen, Lu Li & Yun-e Zhao

  2. Key Laboratory of Vision Science, Ministry of Health, Wenzhou, Zhejiang, China

    Yue Wu, Junhua Li, Man Hu, Yinying Zhao, Xiaolei Lin, Yiqin Chen, Lu Li & Yun-e Zhao

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  1. Yue Wu
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Correspondence to Yun-e Zhao.

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Conflicts of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Ethical approval

This randomized, double-masked, treatment study was approved by the Research Review Board at Wenzhou medical University.

Informed consent

All procedure and studies were conducted in accordance with the tenets of the Declaration of Helsinki, and written informed consent was obtained from all the patients.

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Wu, Y., Li, J., Hu, M. et al. Comparison of two intense pulsed light patterns for treating patients with meibomian gland dysfunction. Int Ophthalmol 40, 1695–1705 (2020). https://doi.org/10.1007/s10792-020-01337-0

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  • DOI: https://doi.org/10.1007/s10792-020-01337-0

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