Abstract
Purpose
This study aimed to compare the choroidal vascularity index (CVI) of eyes having Fuchs’ uveitis syndrome (FUS) with healthy fellow eyes (N).
Methods
This prospective, cross-sectional study included unilateral FUS cases and an age- and gender-matched healthy control group. Thirty-nine participants were included in the FUS group, and 24 age- and gender-matched individuals were randomly selected for the control group. Endothelial cell density (ECD) was measured using Tomey specular microscopy. Spectral-domain optical coherence tomography was used to acquire the choroidal images, and binarization was applied to the images. Two blinded investigators analyzed the CVI in both eyes of the FUS cases and the right eyes of the healthy control group.
Results
CVI was found to be significantly decreased in FUS (p < 0.001). Additionally, ECD had a strong positive correlation with CVI (r = 0.383, p = 0.008).
Conclusion
CVI may provide information about the chronicity of the disease.
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Availability of data and materials
The data supporting our findings can be found at Van Yuzuncu Yil University, Dursun Odabas Faculty of Medicine, Ophthalmology Department, Uveitis section secretary.
References
Kazokoglu H, Onal S, Tugal-Tutkun I, Mirza E, Akova Y, Ozyazgan Y et al (2008) Demographic and clinical features of uveitis in tertiary centers in Turkey. Ophthalmic Epidemiol 15:285–293
Rathinam SR, Namperumalsamy P (2007) Global variation and pattern changes in epidemiology of uveitis. Indian J Ophthalmol 55:173–183
Basarir B, Altan C, Pinarci EY, Celik U, Satana B, Demirok A (2013) Analysis of iris structure and iridocorneal angle parameters with anterior segment optical coherence tomography in Fuchs’ uveitis syndrome. Int Ophthalmol 33:245–250
Kimura SJ, Hogan MJ, Thygeson P (2005) Fuchs’ syndrome of heterochromic cyclitis. Arch Ophthalmol 54(2):179–186
Bonfioli AA, Curi AL, Orefice F (2005) Fuchs’ heterochromic cyclitis. Semin Ophthalmol. 20(3):143–146
Mohamed Q, Zamir E (2005) Update on Fuchs’ uveitis syndrome. Curr Opin Ophthalmol 16:356–363
Kardes E, Sezgin Akcay BI, Unlu C, Ergin A (2017) Choroidal thickness in eyes with Fuchs Uveitis Syndrome. Ocul Immunol Inflamm. 25(2):259–266
Agrawal A, Agarwal R, Khandelwal N, Invernizzi A, Aggarwal K, Sharma A et al (2018) Choroidal structural changes in tubercular multifocal serpiginoid choroiditis. Ocul Immunol Inflamm 26(6):838–844
Agrawal R, Chhablani J, Tan KA, Shah S, Sarvaiya C, Banker A (2016) Choroidal vascularity index in central serous chorioretinopathy. Retina. 36:1646–1651
Agrawal R, Li LKH, Nakhate V, Khandelwal N, Mahendradas P (2016) Choroidal vascularity index in Vogt-Koyanagi–Harada disease: an EDI-OCT derived tool for monitoring disease progression. Transl Vis Sci Technol 5(4):7
Agrawal R, Salman M, Tan KA, Karampelas M, Sim DA, Keane PA et al (2016) Choroidal vascularity index (CVI)-a novel optical coherence tomography parameter for monitoring patients with panuveitis? PLoS One 11(1):e0146344
Ratra D, Tan R, Jaishankar D, Khandelwal N, Gupta A, Chhablani J et al (2018) Choroıdal structural changes and vascularıty ındex ın stargardt dısease on swept source optıcal coherence tomography. Retina 38(12):2395–2400
Tan KA, Laude A, Yip V, Loo E, Wong EP, Agrawal R (2016) Choroidal vascularity index–a novel optical coherence tomography parameter for disease monitoring in diabetes mellitus? Acta Ophthalmol 94(7):e612–e616
Tan R, Agrawal R, Taduru S, Gupta A, Vupparaboina K, Chhablani J (2018) Choroidal vascularity index in retinitis pigmentosa: an OCT study. Ophthalmic Surg Lasers Imaging Retina. 49(3):191–197
Wei X, Ting DSW, Ng WY, Khandelwal N, Agrawal R, Cheung CMG (2017) Choroidal vascularity index: a novel optical coherence tomography based parameter in patients with exudative age-related macular degeneration. Retina 37(6):1120–1125
Ağın A, Kadayıfçılar S, Sönmez HE, Baytaroglu A, Demir S, Sag E et al (2019) Evaluation of choroidal thickness, choroidal vascularity index and peripapillary retinal nerve fiber layer in patients with juvenile systemic lupus erythematosus. Lupus 28(1):44–50
Kurt A, Kurt EE, Kilic R, Oktem C, Tuncay F, Erdem HR (2017) Is choroidal thickness related with disease activity and joint damage in patient with rheumatoid arthritis. Bratisl Lek Listy 118(1):23–27
Balci O, Ozsutcu M (2016) Evaluation of retinal and choroidal thickness in Fuchs’ uveitis syndrome. J Ophthalmol. 2016:1657078
Invernizzi A, Cigada M, Savoldi L, Cavuto S, Fontana L, Cimino L (2014) In vivo analysis of the iris thickness by spectral domain optical coherence tomography. Br J Ophthalmol 98(9):1245–1249
Alfawaz AM, Holland GN, Yu F, Margolis MS, Giaconi JA, Aldave AJ (2016) Corneal endothelium in patients with anterior uveitis. Ophthalmology 123(8):1637–1645
Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 140:509–516
Nussenblatt RB, Palestine AG, Chan CC, Roberge F (1985) Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology 92:467–471
Cerquaglia A, Iaccheri B, Fiore T, Lupidi M, Torroni G, Fruttini D et al (2016) Full-thickness choroidal thinning as a feature of Fuchs Uveitis Syndrome: quantitative evaluation of choroid by enhanced depth imaging optical coherence tomography in a cohort of consecutive patients. Graefes Arch Clin Exp Ophthalmol 254(10):2025–2031
Tugal-Tutkun I, Guney-Tefekli E, Kamaci-Duman F, Corum I (2009) A cross-sectional and longitudinal study of Fuchs uveitis syndrome in Turkish patients. Am J Ophthalmol 148(4):510–515
Koh LHL, Agrawal R, Khandelwal N, Sai Charan L, Chhablani J (2017) Choroidal vascular changes in age-related macular degeneration. Acta Ophthalmol 95:e597–e601
Szepessy Z, Toth G, Barsi A, Kranitz K, Nagy ZZ (2016) Anterior segment characteristics of Fuchs Uveitis Syndrome. Ocul Immunol Inflamm. 24(5):594–598
Huang Z, Wang XY, Liu L, Han W (2014) Corneal decompensation in bilateral Fuchs heterochromic uveitis. Can J Ophthalmol 49(1):e11–e14
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by Van Yuzuncu Yil University, Dursun Odabas Faculty of Medicine, Surgical and Pharmaceutical Research Ethics Board.
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Ozer, M.D., Batur, M., Tekin, S. et al. Choroid vascularity index as a parameter for chronicity of Fuchs’ uveitis syndrome. Int Ophthalmol 40, 1429–1437 (2020). https://doi.org/10.1007/s10792-020-01309-4
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DOI: https://doi.org/10.1007/s10792-020-01309-4