Abstract
Purpose
To study the demographic features, treatment, histopathology, and outcomes in patients of xeroderma pigmentosum (XP) with conjunctival melanoma.
Methods
Retrospective case series.
Results
The median age at presentation was 18 years (range 9–30 years). There were three females and one male patient presenting with a median duration of symptoms of 3 months (range 1–60 months). The tumor was located in the bulbar conjunctiva in all 4 patients. All patients had corneal involvement by the tumor. The median tumor basal diameter was 7 mm (range 4–15 mm). Wide tumor excisional biopsy with alcohol keratoepithelectomy, cryotherapy to the free margins, and amniotic membrane grafting was done in three patients. One patient underwent orbital exenteration for extensive tumor. One patient also received adjuvant plaque brachytherapy for microscopic residual tumor. Over a median follow-up of 22 months (range 2–101 months), there were no recurrences, metastasis, or death.
Conclusion
Conjunctival melanoma in XP is rare and manifests at a younger age.
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Acknowledgements
Support provided by the Operation Eyesight Universal Institute for Eye Cancer (SK) and Hyderabad Eye Research Foundation (SK), Hyderabad, India. The funders had no role in the preparation, review, or approval of the manuscript.
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Vasanthapuram, V.H., Kaliki, S. Conjunctival melanoma in patients with xeroderma pigmentosum: a series of four cases. Int Ophthalmol 40, 1143–1146 (2020). https://doi.org/10.1007/s10792-019-01279-2
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DOI: https://doi.org/10.1007/s10792-019-01279-2