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Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos

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Abstract

Purpose

To describe swept source-OCT (SS-OCT) and swept source-OCT angiography (SS-OCTA) findings in eyes with posterior microphthalmos (PM).

Methods

Twelve eyes (six patients) with PM were evaluated using SS-OCT and SS-OCTA. Structural changes, subfoveal choroidal thickness (SFCT), and perifoveal capillary changes with qualitative and quantitative assessments were analyzed. Twenty eyes served as control group.

Results

SS-OCT findings included elevated retinal papillo-macular fold (75%), retinal pigment epithelium folds (83%), macular cystoid spaces (42%), subretinal fluid (17%), and increased visibility of posterior vitreous cortex and hyaloid (42%). Mean SFCT in PM and in control eyes were 430.33 ± 157.48 µm and 290.05 ± 52.87 µm, respectively (p = 0.004). Perifoveal capillary changes on SS-OCTA included foveal avascular zone (FAZ) remodeling (100%), vessel tortuosity (67%), disorganization of the deep capillary network (67%), intraretinal cystoid spaces (42%), and areas of signal voids in the choriocapillaris (33%). FAZ area was significantly smaller in eyes with PM than in the control group in both the superficial (p < 0.001) and deep capillary plexuses (p = 0.001). Capillary vessel density (CVD) was significantly lower in the PM than in the control group in the deep capillary plexus (p = 0.004). Log MAR BCVA correlated negatively with axial length (r = − 0.929, p < 0.001), FAZ area in both the superficial (r = − 0.637, p < 0.001) and deep capillary plexus (r = − 0.561, p = 0002), and CVD in the deep capillary plexus (r = − 0.450, p = 0.016).

Conclusions

Combined SS-OCT and SS-OCTA allow the detection of various retinal and choroidal structural and microvascular changes in eyes with PM. These findings can provide new insights onto this blinding ocular condition.

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Acknowledgements

This work has been supported by the Ministry of Higher Education and Research of Tunisia.

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Authors and Affiliations

  1. Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, 5019, Monastir, Tunisia

    Nesrine Abroug, Imen Ksiaa, Wejdene Nabi, Sonia Attia, Bechir Jelliti, Sana Khochtali & Moncef Khairallah

  2. Section of Ophthalmology, Department of Surgical and Biomedical Sciences, University of Perugia, S. Maria della Misericordia Hospital, 06156, Perugia, Italy

    Marco Lupidi

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  1. Nesrine Abroug
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Correspondence to Moncef Khairallah.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Abroug, N., Ksiaa, I., Lupidi, M. et al. Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos. Int Ophthalmol 39, 2709–2719 (2019). https://doi.org/10.1007/s10792-019-01115-7

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  • DOI: https://doi.org/10.1007/s10792-019-01115-7

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