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Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

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Abstract

Purpose

To investigate potential changes of vessel density (VD) at the optic nerve head (ONH) and the macula 6 months after trabeculectomy (TE).

Methods

In a prospective monocentric study, 19 eyes with open-angle glaucoma were treated with TE + MMC (mitomycin C). At four different time points multiple morphological papillary parameters were measured by OCT, and the ONH VD in the radial peripapillary capillary layer and the superficial and deep plexuses of the macula was determined by OCTA (optical coherence tomography angiography, RTVue-XR, Optovue). The mean defect was determined by visual field examination (mode 30-2, Humphrey Field Analyzer). The duration of follow-up was 6 months.

Results

Nineteen eyes, one each from 19 patients (11 females; 8 males) with a mean age of 66.0 (58.07, 70.94) years and a mean intraocular pressure (IOP) of 21.0 mmHg (17.07, 23.87), were included in the study. All showed a significant reduction in IOP at each follow-up after TE (p < 0.0001). There was no significant change in the peripapillary retinal nerve fiber layer thickness (p = 0.88), the ganglion cell complex (p = 0.97), the cup–disk ratio (p = 0.63), the rim area (p = 0.78), or the mean visual field defect (p = 0.82). With regard to VD, no significant difference could be determined in either the ONH or the macular area.

Conclusions

After significant surgical reduction of IOP by TE, there are no significant detectable morphological changes in the ONH or the ganglion cell complex as measured by OCT, nor does the papillary or macular OCTA-determined VD change significantly.

Trial registration 2016-409-f-S Avanti-OCT-A. Registered December 1, 2016.

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Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany

    C. Lommatzsch, K. Rothaus, J. M. Koch & C. Heinz

  2. Department of Ophthalmology, University of Essen, Duisburg, Germany

    C. Heinz

  3. Department of Ophthalmology, University of Luebeck, Luebeck, Germany

    S. Grisanti

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  1. C. Lommatzsch
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  2. K. Rothaus
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  3. J. M. Koch
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  4. C. Heinz
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  5. S. Grisanti
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Contributions

CL designed the study, collected data, and wrote the manuscript. KR performed all statistical analysis. JMK, CH, and SG assisted in manuscript writing. All authors read and approved the final manuscript.

Corresponding author

Correspondence to C. Lommatzsch.

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Conflict of interest

CL: lecture, Optovue

All other authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institution and/or national research comittee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Lommatzsch, C., Rothaus, K., Koch, J.M. et al. Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography. Int Ophthalmol 39, 2583–2594 (2019). https://doi.org/10.1007/s10792-019-01107-7

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  • DOI: https://doi.org/10.1007/s10792-019-01107-7

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