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Efficacy of fixation of the amniotic membrane on a symblepharon ring with continuous suturing in acute ocular chemical burn patients

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Abstract

Purpose

To describe a modified non-traumatic amniotic membrane transplantation (AMT) technique and evaluating its efficiency for the ocular surface injury after chemical burn were aimed.

Methods

Twenty eyes of 20 patients (F: 6, M: 14) with acute chemical burn for whom modified non-traumatic AMT was utilized were evaluated retrospectively. In this technique, amniotic membrane (AM) was fixated onto a symblepharon ring with continuous suturing. The healing time of the corneal epithelial defect due to ocular surface chemical injury and melting duration of AM were evaluated. Development of infection or symblepharon, recurrence or persistence of epithelial defect, corneal perforation and the ring falling out with AM were evaluated as complications.

Results

Mean age of the patients was 24.7 ± 11.7 years old (14 months–40 years). Mean duration of applying the non-traumatic AMT after contact with the chemical agent was 8.4 ± 6.2 days (2–21 days). The mean duration of the epithelial defect healing was 27.8 ± 8.8 days (11–40 days) in the grade II, III, and IV (n = 12) cases, while in the grade V and VI (n = 8) cases, a persistent epithelial defect developed, and the mean duration of the epithelial defect healing was 83 ± 23.1 days (42–120 days) (p = 0.0002). The mean melting duration of the AM was 22.7 ± 10 days (10–42 days).

Conclusion

By using this modified AMT technique, AM can be utilized efficiently, easily, and non-traumatically in every center for the treatment of the ocular surface injury due to chemical burn.

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References

  1. Kim JC, Tseng SC (1995) Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 14:473–484

    Article  CAS  Google Scholar 

  2. Kim JS, Kim JC, Na BK, Jeong JM, Song CY (2000) Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn. Exp Eye Res 70:329–337

    Article  CAS  PubMed  Google Scholar 

  3. Liu T, Zhai H, Xu Y, Dong Y, Sun Y, Zang X et al (2012) Amniotic membrane traps and induces apoptosis of inflammatory cells in ocular surface chemical burn. Mol Vis 18:2137–2146

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Kobayashi A, Shirao Y, Yoshita T, Yagami K, Segawa Y, Kawasaki K et al (2003) Temporary amniotic membrane patching for acute chemical burns. Eye (Lond, Engl) 17:149–158

    Article  CAS  Google Scholar 

  5. Liang X, Liu Z, Lin Y, Li N, Huang M, Wang Z (2012) A modified symblepharon ring for sutureless amniotic membrane patch to treat acute ocular surface burns. J Burn Care Res 33:e32–e38

    Article  PubMed  Google Scholar 

  6. Prabhasawat P, Tesavibul N, Prakairungthong N, Booranapong W (2007) Efficacy of amniotic membrane patching for acute chemical and thermal ocular burns. J Med Assoc Thail 90:319–326

    Google Scholar 

  7. Tamhane A, Vajpayee RB, Biswas NR, Pandey RM, Sharma N, Titiyal JS et al (2005) Evaluation of amniotic membrane transplantation as an adjunct to medical therapy as compared with medical therapy alone in acute ocular burns. Ophthalmology 112:1963–1969

    Article  PubMed  Google Scholar 

  8. Kucukerdonmez C, Karalezli A, Akova YA, Borazan M (2010) Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial. Eye (Lond, Engl) 24:558–566

    Article  CAS  Google Scholar 

  9. Chawla B, Tandon R (2008) Sutureless amniotic membrane fixation with fibrin glue in symptomatic bullous keratopathy with poor visual potential. Eur J Ophthalmol 18:998–1001

    Article  CAS  PubMed  Google Scholar 

  10. Hick S, Demers PE, Brunette I, La C, Mabon M, Duchesne B (2005) Amniotic membrane transplantation and fibrin glue in the management of corneal ulcers and perforations: a review of 33 cases. Cornea 24:369–377

    Article  PubMed  Google Scholar 

  11. Kheirkhah A, Casas V, Sheha H, Raju VK, Tseng SC (2008) Role of conjunctival inflammation in surgical outcome after amniotic membrane transplantation with or without fibrin glue for pterygium. Cornea 27:56–63

    Article  PubMed  Google Scholar 

  12. Sridhar MS, Bansal AK, Rao GN (2002) Surgically induced necrotizing scleritis after pterygium excision and conjunctival autograft. Cornea 21:305–307

    Article  CAS  PubMed  Google Scholar 

  13. Pruet CM, Queen JH, Kim G (2014) Amnion doughnut: a novel method for sutureless fixation of amniotic membrane to the bulbar and palpebral conjunctiva in acute ocular-involving Stevens–Johnson syndrome. Cornea 33:1240–1244

    Article  PubMed  PubMed Central  Google Scholar 

  14. Suri K, Kosker M, Raber IM, Hammersmith KM, Nagra PK, Ayres BD et al (2013) Sutureless amniotic membrane ProKera for ocular surface disorders: short-term results. Eye Contact Lens 39:341–347

    Article  PubMed  Google Scholar 

  15. Uhlig CE, Busse H (2010) Development and evaluation of a device for sutureless and repeated application of amniotic membrane overlays. Cornea 29:331–335

    Article  PubMed  Google Scholar 

  16. John T, Foulks GN, John ME, Cheng K, Hu D (2002) Amniotic membrane in the surgical management of acute toxic epidermal necrolysis. Ophthalmology 109:351–360

    Article  PubMed  Google Scholar 

  17. Dua HS, King AJ, Joseph A (2001) A new classification of ocular surface burns. Br J Ophthalmol 85:1379–1383

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Ucakhan OO, Koklu G, Firat E (2002) Nonpreserved human amniotic membrane transplantation in acute and chronic chemical eye injuries. Cornea 21:169–172

    Article  PubMed  Google Scholar 

  19. Liu BQ, Wang ZC, Liu LM, Liu JB, Li NY, Wang LN et al (2008) Sutureless fixation of amniotic membrane patch as a therapeutic contact lens by using a polymethyl methacrylate ring and fibrin sealant in a rabbit model. Cornea 27:74–79

    Article  PubMed  Google Scholar 

  20. Szurman P, Warga M, Grisanti S, Roters S, Rohrbach JM, Aisenbrey S et al (2006) Sutureless amniotic membrane fixation using fibrin glue for ocular surface reconstruction in a rabbit model. Cornea 25:460–466

    Article  PubMed  Google Scholar 

  21. Resch MD, Schlotzer-Schrehardt U, Hofmann-Rummelt C, Sauer R, Kruse FE, Beckmann MW et al (2006) Integration patterns of cryopreserved amniotic membranes into the human cornea. Ophthalmology 113:1927–1935

    Article  PubMed  Google Scholar 

  22. Ma KN, Thanos A, Chodosh J, Shah AS, Mantagos IS (2016) A novel technique for amniotic membrane transplantation in patients with acute Stevens–Johnson syndrome. Ocul Surf 14:31–36

    Article  PubMed  Google Scholar 

  23. Kotomin I, Valtink M, Hofmann K, Frenzel A, Morawietz H, Werner C et al (2015) Sutureless fixation of amniotic membrane for therapy of ocular surface disorders. PLoS ONE 10:e0125035

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, 34098, Istanbul, Turkey

    Cezmi Dogan, Osman Sevki Arslan, Akif Ozdamar, Burak Mergen, Ahmet Murat Sarici & Guzin Iskeleli

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  1. Cezmi Dogan
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  2. Osman Sevki Arslan
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  3. Akif Ozdamar
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  4. Burak Mergen
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  5. Ahmet Murat Sarici
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  6. Guzin Iskeleli
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Correspondence to Cezmi Dogan.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Dogan, C., Arslan, O.S., Ozdamar, A. et al. Efficacy of fixation of the amniotic membrane on a symblepharon ring with continuous suturing in acute ocular chemical burn patients. Int Ophthalmol 39, 2103–2109 (2019). https://doi.org/10.1007/s10792-018-1049-1

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  • DOI: https://doi.org/10.1007/s10792-018-1049-1

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