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Case report: acute hydrops and spontaneous corneal perforation in a patient with keratoconus treated with colchicine for familial Mediterranean fever

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Abstract

Purpose

To report a rare case of spontaneous corneal perforation after hydrops in keratoconus patients who suffer from familial Mediterranean fever and was treated systemically with Colchicine.

Methods

Case report.

Results

We report a case of a 30-year-old male with keratoconus and familial Mediterranean fever treated with colchicine, presented with acute hydrops in his left eye, which progressed to a spontaneous corneal perforation. Attempts to treat the perforation with cyanoacrylate glue failed, and he underwent penetrating keratoplasty with an excellent visual outcome.

Conclusion

Colchicine treatment may have had a role in the pathogenesis of this rare case.

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Abbreviations

FMF:

Familial Mediterranean fever

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Authors and Affiliations

  1. Department of Ophthalmology, Kaplan Medical Center, Rehovot, Israel

    Assaf Hilely & Guy Kleinmann

  2. Affiliated with the Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Assaf Hilely & Guy Kleinmann

Authors
  1. Assaf Hilely
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  2. Guy Kleinmann
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Corresponding author

Correspondence to Assaf Hilely.

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Conflict of interest

Assaf Hilely and Guy Kleinmann declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

The patient has consented to the submission of the case report for submission to the journal.

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Hilely, A., Kleinmann, G. Case report: acute hydrops and spontaneous corneal perforation in a patient with keratoconus treated with colchicine for familial Mediterranean fever. Int Ophthalmol 39, 1367–1369 (2019). https://doi.org/10.1007/s10792-018-0924-0

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  • DOI: https://doi.org/10.1007/s10792-018-0924-0

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