Further observations on a bilateral IRVAN syndrome case
- 27 Downloads
Reporting clinical features of the late course of the disease after long-term follow-up in a bilaterally affected patient with idiopathic retinitis, vasculitis, retinal aneurysms and neuroretinitis (IRVAN) and new peripheral retinal findings on wide-field angiography and multimodal imaging.
This was a retrospective observational study, based on current diagnostic studies including wide-field fluorescein angiography, optical coherence tomography (OCT) and treatment of aneurysms with argon laser photocoagulation.
A 21-year-old female with bilateral IRVAN syndrome—stage 2 in the right eye and stage 3 in the left eye—previously treated bilaterally with laser photocoagulation for retinal macroaneurysms and ischemic areas between 1985 and 1992. Follow-up interrupted on two occasions, with subsequent fundus re-examinations confirming the prevention of retinal neovascularization in both eyes, as recently evidenced on wide-field angiography.
A case of bilateral IRVAN disease with multiple retinal aneurysms, neuroretinitis and peripheral capillary nonperfusion successfully treated with laser photocoagulation, maintaining normal visual acuity in one eye and preventing retinal neovascular complications.
KeywordsRetinal aneurysms Uveitis Vasculitis Neuroretinitis Wide-field angiography
We thank to Jean J Delaey MD and Rosario Camacho for draft manuscript review. Also thanks to Marcela Valencia MD, Claudia Castaño, Claudia Rojas and Julieth Cortés for their collaboration.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Other methods of treatment, currently available, can be used for comparison, if required. Written informed consent was obtained from the patient for publication of this bilateral case report and the accompanying images.
- 2.Verdaguer J (1978) Enfermedades vasculares de la retina y su tratamiento. Conferencia Charlin, Arch Chil Oftalm, vol XXXV no 1, pp 35–38Google Scholar
- 4.Melan P, Ciurana AJ, Boudet C (1986) Arterie retinienne bilaterale avec dilatations aneurysmalls multiples. J Fr Ophthalmol 9:23–28Google Scholar
- 6.Samuel MA, Equi RA, Chang TS, Mieler W, Jampol LM, Hay D, Yannuzzi LA (2007) Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN): new observations and a proposed staging system. Ophthalmology 114(1526–1529):e1Google Scholar
- 7.Basha M, Brown GC, Palombaro G, Shields CL, Shields JA (2014) Management of IRVAN syndrome with observation. Ophthalmic Surg Lasers Imaging Retina 1:45Google Scholar