Could corneal densitometry be used as a diagnostic and screening tool for ocular involvement in patients with gout?

  • Pinar Kosekahya
  • Kadir Gokhan Atilgan
  • Cemile Ucgul Atilgan
  • Kemal Tekin
  • Mustafa Koc
  • Mehtap Caglayan
  • Deniz Ayli
  • Pelin Yilmazbas
Original Paper



To evaluate the corneal and tear film characteristics in patients with gout and compare these data with those of healthy subjects and to investigate the correlation of corneal densitometry with uric acid value and duration of disease.


Forty-one eyes of 41 patients with gout (group 1) and 40 eyes of 40 healthy subjects (group 2) were included in this study. Detailed ophthalmologic examinations were performed on all participants. Corneal tomographic analyses were performed with the Pentacam HR Scheimpflug imaging system (Oculus, Wetzlar, Germany). Maximum keratometry (Kmax), central corneal thickness (CCT), corneal volume (CV), and corneal densitometric values were compared between groups. Tear function tests including Schirmer, tear breakup time, and fluorescein staining were performed and compared between groups.


Groups were similar in terms of age and gender. Kmax, CCT, and CV values were similar between groups. The outcomes of tear function tests were similar between groups. Corneal densitometric values for the 0–2 and 2–6 mm zones of the anterior and center layers were significantly higher in group 1 compared to group 2. This densitometric increase was positively correlated with uric acid levels and gout duration.


Corneal densitometry values of the 0–2 and 2–6 mm zones of the anterior and central layers were higher in patients with gout than those of the control subjects, and the densitometric values increased as uric acid level and disease duration increased.


Corneal densitometry Gout Tear film tests 


Compliance with ethical standards

Conflict of interest

The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Pinar Kosekahya
    • 1
  • Kadir Gokhan Atilgan
    • 2
  • Cemile Ucgul Atilgan
    • 1
  • Kemal Tekin
    • 3
  • Mustafa Koc
    • 1
  • Mehtap Caglayan
    • 4
  • Deniz Ayli
    • 2
  • Pelin Yilmazbas
    • 1
  1. 1.Department of OphthalmologyUlucanlar Eye Training and Research HospitalAnkaraTurkey
  2. 2.Department of NephrologyDiskapi Yildirim Beyazıt Training and Research HospitalAnkaraTurkey
  3. 3.Department of OphthalmologyKars State HospitalKarsTurkey
  4. 4.Department of OphthalmologyGazi Yasargil Training and Research HospitalDiyarbakirTurkey

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