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Efficacy of locally produced Latanoprost in the control of intraocular pressure in patients with primary open-angle glaucoma

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Abstract

Purpose

To determine the efficacy of locally produced Latanoprost in reducing the intraocular pressure (IOP) in patients with Primary open-angle glaucoma (POAG).

Design

Open-label, non-comparative, observational case study with non-probability purposive sampling.

Methods

A total of 48 patients (94 eyes) of either gender were recruited from glaucoma clinic with the diagnosis of POAG, having IOP of more than 21 mmHg. Patients were commenced on locally produced Latanoprost (Vislat 0.005%). IOP was subsequently measured at 4 weeks and 12 weeks, respectively. The primary end point was reduction in IOP at 12 weeks after the initiation of treatment.

Results

A total of 48 patients (94 eyes) were recruited from glaucoma clinic. The average IOP of our patients at baseline was 28.6 ± 8.1 mmHg, decreasing to 21.3 ± 10.6 mmHg at 4 weeks, indicating a drop of 19.1% (P < 0.001). IOP further decreased to 20.3 ± 8.7 mmHg after 3 months of treatment indicating a decrease of 23.3% (P < 0.001). A decrease in IOP occurred in 51 eyes (71.8%) at 4 weeks after treatment, improving to 54 eyes (76%) at 3-month follow-up. Twenty eyes (28.1%) did not show any change in IOP at 4 weeks. However, after 3-month follow-up only 17 eyes (23.9%) did not reveal any change in IOP.

Conclusion

Our results showed a decrease in IOP of 19.1% after 4 weeks, increasing to 23.3% at 12 weeks in cohort of 37 patients (72 eyes) treated with locally produced Latanoprost (Vislat 0.005%).

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Acknowledgements

We are thankful to Dr. Mujahid Inam, Dr. Nasir Memon and Dr. Shahid Rashidi for recruiting and enrolling the patients, Muhammad Faisal Fahim for statistical analysis and Azfar Ali for typing the manuscript.

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Authors and Affiliations

  1. Isra Postgraduate Institute of Ophthalmology, Al-Ibrahim Eye Hospital, GadapTown, Malir, Karachi, Pakistan

    Pir Salim Mahar

  2. Aga Khan University Hospital, Karachi, Pakistan

    Pir Salim Mahar

  3. Allama Iqbal Medical College, Lahore, Pakistan

    Nadeem H. Butt

  4. Al-Nafees Medical College, Islamabad, Pakistan

    Syed Imtiaz Ali

Authors
  1. Pir Salim Mahar
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  2. Nadeem H. Butt
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  3. Syed Imtiaz Ali
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Correspondence to Pir Salim Mahar.

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The authors declare that they have no conflict of interest.

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Mahar, P.S., Butt, N.H. & Ali, S.I. Efficacy of locally produced Latanoprost in the control of intraocular pressure in patients with primary open-angle glaucoma. Int Ophthalmol 38, 2593–2597 (2018). https://doi.org/10.1007/s10792-017-0773-2

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  • DOI: https://doi.org/10.1007/s10792-017-0773-2

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