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Transepithelial accelerated corneal collagen cross-linking with higher oxygen availability for keratoconus: 1-year results

  • Ling Sun
  • Meng Li
  • Xiaoyu Zhang
  • Mi Tian
  • Tian Han
  • Jing Zhao
  • Xingtao Zhou
Original Paper
  • 89 Downloads

Abstract

Purpose

To investigate the safety and efficacy of a new protocol for transepithelial accelerated corneal collagen cross-linking with higher oxygen availability for keratoconus treatment.

Methods

There were 26 patients (26 eyes) diagnosed with keratoconus enrolled in the study and treated with transepithelial accelerated corneal collagen cross-linking. The corneas were irradiated using UVA light for 5 min and 20 s with 45 mW/cm2 irradiance and pulsed illumination (1:1). The follow-up examinations were performed at 1 day, 1 month, 3 months, 6 months, and 1 year postoperatively. At each follow-up, the patients received a complete ophthalmologic examination that included visual acuity, manifest refraction, corneal topography, endothelial cell density, and ORA.

Results

The operations were uneventful, and there were no complications during follow-up. At 1 year after the procedure, the uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) of the treated eyes were significantly improved compared to the pretreatment values (P = 0.012, 0.041, respectively). Additionally, 65.4% of eyes gained at least 1 line in CDVA, and 42.3% of eyes showed a reduction in at least 0.5D in astigmatism. The maximum keratometry (K max), corneal thickness, corneal endothelial cell density and corneal biomechanics were stable at each visit.

Conclusion

Transepithelial accelerated corneal collagen cross-linking with higher oxygen availability was safe for keratoconus treatment and partially prevented disease progression. Therefore, further studies with large patient cohorts and longer follow-up periods are recommended.

Keywords

Transepithelial accelerated corneal collagen cross-linking Keratoconus Pulsed illumination Safety Efficacy 

Notes

Funding

This study was funded by the National Natural Science Foundation of China (Grant No. 81570879), the National Natural Science Foundation of China for Young Scholars (Grant No. 81600762). The sponsors and funding organizations had no role in the design or conduct of this research.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of Ethical Committee of the Fudan University EENT Hospital Review Board and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Ling Sun
    • 1
  • Meng Li
    • 1
  • Xiaoyu Zhang
    • 1
  • Mi Tian
    • 1
  • Tian Han
    • 1
  • Jing Zhao
    • 1
  • Xingtao Zhou
    • 1
  1. 1.Key Laboratory of Myopia, Ministry of Health, Department of Ophthalmology, Eye and ENT HospitalFudan UniversityShanghaiChina

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