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The influence of mitomycin C concentration on the outcome of trabeculectomy in uveitic glaucoma

  • Faisal A. Almobarak
  • Ali H. Alharbi
  • Jose Morales
  • Ibrahim Aljadaan
Original Paper

Abstract

Purpose

To evaluate the influence of mitomycin C (MMC) concentration on the outcome of trabeculectomy in uveitic glaucoma.

Methods

Retrospective comparative study included 50 patients who underwent MMC-enhanced trabeculectomy for uncontrolled uveitic glaucoma. Patients were divided into two groups based on the concentration of MMC used during trabeculectomy (high [0.04%] or low [0.02%]). The main outcome measures were: the intraocular pressure (IOP), the number of antiglaucoma medications, the need for further glaucoma surgeries, and trabeculectomy success.

Results

There were no differences in the IOP nor antiglaucoma medications. The success rates were 76.0 and 68.0%, while the failure rates were 24.0 and 32.0% in the 0.02 and 0.04% MMC groups, respectively.

Conclusion

Trabeculectomy augmented with low (0.02%) MMC concentration seems to have comparable outcomes in uveitic glaucoma compared with high (0.04%) concentration.

Keywords

Glaucoma Mitomycin C Outcome Trabeculectomy Uveitis 

Notes

Acknowledgements

This work was supported by College of Medicine Research Center. Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Faisal A. Almobarak
    • 1
    • 2
  • Ali H. Alharbi
    • 2
    • 3
  • Jose Morales
    • 2
  • Ibrahim Aljadaan
    • 2
  1. 1.Department of Ophthalmology, College of MedicineKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Glaucoma DivisionKing Khaled Eye Specialist HospitalRiyadhSaudi Arabia
  3. 3.King Abdullah Medical CityMakkahSaudi Arabia

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