Neuro-ophthalmological findings in TAFRO syndrome in a patient from South America, a variant of multicentric Castleman’s disease



To report the neuro-ophthalmological findings in the TAFRO syndrome in a South American patient.


This is a case report of a patient with TAFRO syndrome.


We present the case of a 66-year-old woman with TAFRO syndrome and multicentric Castleman disease, who developed ophthalmic manifestations, as a rare complication, including optic disk edema and serous retinal detachment, which improved with conventional therapy.


The optic disk edema could be present as a neuro-ophthalmological finding in TAFRO syndrome. To the best of our knowledge, this is the first report on the ophthalmic manifestations in the TAFRO syndrome.

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Correspondence to Alvaro Ortiz.

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All the scientific and ethical principles of the Helsinki Declaration on Human Research were respected.

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Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

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The authors declare that there is no conflict of interest.


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Ortiz, A., Cárdenas, P., Peralta, M. et al. Neuro-ophthalmological findings in TAFRO syndrome in a patient from South America, a variant of multicentric Castleman’s disease. Int Ophthalmol 38, 1641–1646 (2018).

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  • Optic nerve disease
  • Multicentric Castleman’s disease
  • Electrophysiology
  • Thrombocytopenia