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The clinical characteristics and prognosis of acute zonal occult outer retinopathy

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Abstract

Purpose

This prospective observational case series study aimed to observe the clinical characteristics of acute zonal occult outer retinopathy (AZOOR) and its prognosis in Chinese Han patients.

Methods

Six eyes of 5 female patients diagnosed with AZOOR were followed up for 4 months to observe the natural disease course. All enrolled subjects underwent a series of ocular examinations at the onset and each return visit, including best corrected visual acuity (BCVA), split lamp microscopy, fundus photography, optical coherence tomography (OCT), perimetry, multifocal electroretinogram and fundus fluorescein angiography.

Results

Over the follow-up, all enrolled patients recovered on BCVA, perimetry and OCT in different degrees. Among them, one patient recovered completely since the ocular examination results returned to normal.

Conclusion

AZOOR is a rare ocular disorder in Chinese population. Our results demonstrated that visual functions of enrolled patients significantly improved spontaneously, indicating that Chinese female Han patients with AZOOR have good visual outcomes during the follow-up period without any specific managements.

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Acknowledgements

We are grateful to Dr. Yanbo Shi (Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University) and Ms. Julie Qiaojin Lin (Department of Physiology, Development and Neuroscience, University of Cambridge) for editing the manuscript.

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Author notes

  1. Shancheng Si and Wei Song have contributed equally to the present work.

Authors and Affiliations

  1. Department of Ophthalmology, Beijing Tsinghua Changgung Hospital, Tsinghua University, No. 168 Litang Road, Changping District, Beijing, 102218, China

    Shancheng Si & Yuntao Hu

  2. Department of Ophthalmology, Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Zhongshan East Road 1501, Nanhu District, Jiaxing City, 314000, Zhejiang Province, China

    Wei Song

  3. Department of Ophthalmology, Peking University Third Hospital, 49 Huayuan North Road, Haidian District, Beijing, 100191, China

    Yifan Song & Yuntao Hu

Authors
  1. Shancheng Si
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  2. Wei Song
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  3. Yifan Song
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  4. Yuntao Hu
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Corresponding author

Correspondence to Yuntao Hu.

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Si, S., Song, W., Song, Y. et al. The clinical characteristics and prognosis of acute zonal occult outer retinopathy. Int Ophthalmol 38, 1177–1185 (2018). https://doi.org/10.1007/s10792-017-0580-9

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