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Increased red cell distribution width levels in children with seasonal allergic conjunctivitis

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Seasonal allergic conjunctivitis (SAC) is an inflammatory disease of the conjunctiva. Red cell distribution width (RDW) is a widely accepted inflammatory marker. We aimed to investigate whether RDW level is associated with the development of SAC in pediatric population.


The present study consisted of 90 subjects (45 children with SAC and 45 age- and sex-matched healthy children). The demographic findings, complete blood count parameters including RDW and laboratory parameters, were evaluated.


The mean RDW levels were significantly higher in children with SAC compared to the control group (14.02 ± 0.82 vs. 13.26 ± 0.64%, respectively, p < 0.001). In receiver operating characteristic analysis, the area under the curve for RDW for predicting SAC was 0.786, and a RDW value of 13.45 or higher predicted SAC with a sensitivity of 75.6% and specificity of 65%.


Our study suggests that elevated RDW levels are significantly associated with SAC in pediatric population, which may imply a possible role of increased inflammatory status and oxidative stress in the pathogenesis of SAC.

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  1. Galicia-Carreón J, Santacruz C, Ayala-Balboa J et al (2013) An imbalance between frequency of CD4+ CD25+ FOXP3+ regulatory T cells and CCR4+ and CCR9+ circulating helper T cells is associated with active perennial allergic conjunctivitis. Clin Dev Immunol 2013:919742

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Dadaci Z, Oncel M, Oncel Acir N, Sahin E, Borazan M (2015) Oxidative stress parameters and serum magnesium levels in patients with seasonal allergic conjunctivitis. Cutan Ocul Toxicol 10:1–5

    Google Scholar 

  3. Ozcan F, Turak O, Durak A et al (2013) Red cell distribution width and inflammation in patients with non-dipper hypertension. Blood Press 22:80–85

    Article  PubMed  CAS  Google Scholar 

  4. Jimenez-Baez MV, Marquez-Gonzalez H, Barcenas-Contreras R, Morales Montoya C, Espinosa-Garcia LF (2015) Early diagnosis of diabetic retinopathy in primary care. Colomb Med (Cali) 46:14–18

    Google Scholar 

  5. Tsuboi S, Miyauchi K, Kasai T et al (2013) Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention. Circ J 77:456–461

    Article  PubMed  Google Scholar 

  6. Torkildsen G, Narvekar A, Bergmann M (2015) Efficacy and safety of olopatadine hydrochloride 0.77% in patients with allergic conjunctivitis using a conjunctival allergen-challenge model. Clin Ophthalmol 9:1703–1713

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Aksoy ŞN, Savaş E, Sucu M, Kisacik B, Kul S, Zengin O (2015) Association between red blood cell distribution width and disease activity in patients with Behçet’s disease. J Int Med Res 43:765–773

    Article  PubMed  Google Scholar 

  8. Kurtul BE, Ozer PA, Kabatas EU (2016) Elevated neutrophil-to-lymphocyte ratio in pseudoexfoliation syndrome. Eye (Lond) 30:1045–1048

    Article  CAS  Google Scholar 

  9. Kurtul BE, Ozer PA (2016) The relationship between neutrophil-to-lymphocyte ratio and age-related macular degeneration. Korean J Ophthalmol 30:377–381

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Lippi G, Buonocore R, Picanza A, Schirosa F, Cervellin G (2016) Red blood cell distribution width and haemoglobin are associated with hospital admission in patients with acute allergic reactions. Br J Biomed Sci 73:21–24

    Article  PubMed  Google Scholar 

  11. Ackerman S, Smith LM, Gomes PJ (2016) Ocular itch associated with allergic conjunctivitis: latest evidence and clinical management. Ther Adv Chronic Dis 7:52–67

    Article  PubMed  PubMed Central  Google Scholar 

  12. Akil H, Celik F, Ulas F, Kara IS (2015) Dry eye syndrome and allergic conjunctivitis in the pediatric population. Middle East Afr J Ophthalmol 22:467–471

    Article  PubMed  PubMed Central  Google Scholar 

  13. Dadaci Z, Borazan M, Kiyici A, Oncel Acir N (2014) Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis. Acta Ophthalmol 92:e443–446

    Article  PubMed  CAS  Google Scholar 

  14. Malu KN (2014) Allergic conjunctivitis in Jos-Nigeria. Niger Med J 55:166–170

    Article  PubMed  PubMed Central  Google Scholar 

  15. Dartt DA, Masli S (2014) Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation. Curr Opin Allergy Clin Immunol 14:464–470

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Maziak W, Behrens T, Brasky TM et al (2003) Are asthma and allergies in children and adolescents increasing? Results from ISAAC phase I and phase III surveys in Münster, Germany. Allergy 58:572–579

    Article  PubMed  CAS  Google Scholar 

  17. Abelson MB, Leonardi A, Smith L (2002) The mechanisms, diagnosis and treatment of allergy. Rev Ophthalmol 9:74–84

    Google Scholar 

  18. Bielory L (2008) Ocular allergy overview. Immunol Allergy Clin North Am 28:1–23

    Article  PubMed  Google Scholar 

  19. Bacsi A, Dharajiya N, Choudhury BK, Sur S, Boldogh I (2005) Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis. J Allergy Clin Immunol 116:836–843

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  20. Kurtul A, Murat SN, Yarlioglues M et al (2015) The association of red cell distribution width with in-stent restenosis in patients with stable coronary artery disease. Platelets 26:48–52

    Article  PubMed  CAS  Google Scholar 

  21. Dogru M, Yesiltepe Mutlu RG (2016) The evaluation of neutrophil-lymphocyte ratio in children with asthma. Allergol Immunopathol (Madr) 44:292–296

    Article  CAS  Google Scholar 

  22. Dogru M, Evcimik MF, Cirik AA (2016) Is neutrophil-lymphocyte ratio associated with the severity of allergic rhinitis in children. Eur Arch Otorhinolaryngol 273:3175–3178

    Article  PubMed  Google Scholar 

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Correspondence to Bengi Ece Kurtul.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Kurtul, B.E., Kabatas, E.U., Boybeyi, S.D. et al. Increased red cell distribution width levels in children with seasonal allergic conjunctivitis. Int Ophthalmol 38, 1079–1084 (2018).

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