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Relationship between intraocular pressure, anterior chamber depth and lens thickness in primary open-angle glaucoma patients

International Ophthalmology volume 38, pages 541–547 (2018)Cite this article

Abstract

Introduction

To investigate the relationship between intraocular pressure (IOP), anterior chamber depth (ACD) and lens thickness (LT) in primary open-angle glaucoma (POAG) patients and compare with age- and sex-matched controls.

Methods

A cross-sectional analytical study of 62 newly diagnosed POAG patients compared with 62 age- and sex-matched control subjects in a tertiary eye clinic. Socio-demographic data and ocular examinations were documented. IOP was measured using the Goldmann applanation tonometer. LT and ACD were measured using A-scan ultrasonography and the IOLMaster, respectively. Data were analyzed using SPSS version 19.0 and level of significance set at p value <0.05.

Results

In the glaucoma group and control groups, respectively, mean age was 60.3 ± 8.9 and 58.5 ± 8.1 years (p = 0.234), mean IOP was 28.27 ± 7.88 and 14.47 ± 2.60 mmHg (p < 0.001), mean ACD was 3.12 ± 0.27 and 3.15 ± 0.24 mm (p = 0.514), mean LT was 4.24 ± 0.46 and 4.23 ± 0.45 mm (p = 0.903), and mean ACD was shallower in females (p = 0.034) and (p = 0.001). In the glaucoma group, there was a positive correlation between IOP and ACD (r = 0.022, p = 0.864), but a negative correlation between IOP and LT (r = −0.04, p = 0.758) and ACD and LT (r = −0.058, p = 0.657). In the control group, there was a positive correlation between IOP and ACD (r = 0.141, p = 0.275), IOP and LT (r = 0.031, p = 0.811) and ACD and LT (r = 0.016, p = 0.901).

Conclusion

ACD is shallower in females. There is no significant correlation between IOP and ACD or between IOP and LT in POAG as well as normal individuals.

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Acknowledgements

Partial financial support was received from the Obafemi Awolowo University Teaching Hospitals’ Complex, Ile-Ife, Nigeria in support of the study.

Funding

This study was partly funded by the Obafemi Awolowo University Teaching Hospitals’ Complex Ile-Ife, Nigeria.

Conference presentation

This manuscript has been presented in part at the 39th Annual General Meeting/Scientific Meeting of the Ophthalmological Society of Nigeria at the Premier Hotel, Ibadan, Nigeria on August 27, 2014.

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Affiliations

  1. Ophthalmology Department, College of Heath Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria

    Bolajoko A. Adewara, Bernice O. Adegbehingbe & Oluwatoyin H. Onakpoya

  2. Ophthalmology Department, Lily Hospitals Limited, Warri, Nigeria

    Chidi G. Ihemedu

Authors
  1. Bolajoko A. Adewara
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  2. Bernice O. Adegbehingbe
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  3. Oluwatoyin H. Onakpoya
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  4. Chidi G. Ihemedu
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Corresponding author

Correspondence to Bolajoko A. Adewara.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the Ethics and Research Committee of the Obafemi Awolowo University Teaching Hospitals’ Complex, Ile-Ife and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Adewara, B.A., Adegbehingbe, B.O., Onakpoya, O.H. et al. Relationship between intraocular pressure, anterior chamber depth and lens thickness in primary open-angle glaucoma patients. Int Ophthalmol 38, 541–547 (2018). https://doi.org/10.1007/s10792-017-0488-4

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  • DOI: https://doi.org/10.1007/s10792-017-0488-4

Keywords

  • Anterior chamber depth
  • Intraocular pressure
  • Lens thickness
  • Nigeria
  • Primary open-angle glaucoma