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Conjunctival cytologic features in patients with unilateral primary acquired nasolacrimal duct obstruction

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Abstract

Purpose

To evaluate the cytologic features of conjunctival epithelium in patients with unilateral primary acquired nasolacrimal duct obstruction (PANDO) using impression cytology.

Methods

Twenty-four patients with unilateral PANDO for at least 1 year were enrolled in this study. The healthy eyes of the patients are assessed as control group. All patients were subjected to ophthalmic surface examination with conjunctival impression cytology analysis. Squamous metaplasia and goblet cell density were graded according to Nelson grading system.

Results

The mean age was 52.7 ± 16.3 (range 21–70) years. The mean period for complaints of epiphora was 3.2 ± 2.4 (range 1–8) years. The eye with PANDO had a mean squamous metaplasia grade of 2.38 ± 0.59 versus 1.91 ± 0.82 for control eyes (p = 0.011). The mean grade of goblet cell density was 2.0 ± 0.51 for eyes with PANDO and 2.38 ± 0.65 for control eyes (p = 0.013). There was no statistically significant correlation between conjunctival cytological features in terms of squamous metaplasia and goblet cell density grades and duration of epiphora complaint (r = −0.04, p = 0.82; r = 0.09, p = 0.66, respectively).

Conclusions

PANDO may cause alterations in conjunctival impression cytology. Successful dacryocystorhinostomy surgeries will help to protect ocular surface health.

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References

  1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007) Ocul Surf 5:75–92

  2. Yuksel N, Akcay E, Ayan B, Duru N (2016) Tear-film osmolarity changes following dacryocystorhinostomy in primary acquired nasolacrimal duct obstruction. Curr Eye Res 15:1–3

    Google Scholar 

  3. Calonge M, Diebold Y, Sáez V et al (2004) Impression cytology of the ocular surface: a review. Exp Eye Res 78:457–472

    Article  CAS  PubMed  Google Scholar 

  4. Rivas L, Oroza MA, Perez-Esteban A, Murube-del-Castillo J (1992) Morphological changes in ocular surface in dry eyes and other disorders by impression cytology. Graefes Arch Clin Exp Ophthalmol 230:329–334

    Article  CAS  PubMed  Google Scholar 

  5. Anshu MMM, Sathe V, Ganar A (2001) Conjunctival impression cytology in contact lens wearers. Cytopathology 12:314–320

    Article  CAS  PubMed  Google Scholar 

  6. Nelson JD (1988) Impression cytology. Cornea 7:71–81

    Article  CAS  PubMed  Google Scholar 

  7. Doughty MJ (2015) Assessment of size and nucleo-cytoplasmic characteristics of the squamous cells of the corneal epithelium. Clin Exp Optom 98:218–223

    Article  PubMed  Google Scholar 

  8. Tseng SC (1985) Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology 92:728–733

    Article  CAS  PubMed  Google Scholar 

  9. Lee JK, Kim TH (2014) Changes in cytokines in tears after endoscopic endonasal dacryocystorhinostomy for primary acquired nasolacrimal duct obstruction. Eye Lond 28:600–607

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chan MF, Sack R, Quigley DA et al (2011) Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci 88:1005–1009

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kang MH, Kim MK, Lee HJ, Lee HI, Wee WR, Lee JH (2011) Interleukin-17 in various ocular surface inflammatory diseases. J Korean Med Sci 26:938–944

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Lim SA, Nam DH, Lee JH, Kwok SK, Park SH, Chung SH (2015) Association of IL-21 cytokine with severity of primary Sjögren syndrome dry eye. Cornea 34:248–252

    Article  PubMed  Google Scholar 

  13. Ordoñez CL, Khashayar R, Wong HH et al (2001) Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 163:517–523

    Article  PubMed  Google Scholar 

  14. Kim YS, Ho SB (2010) Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep 12:319–330

    Article  PubMed  PubMed Central  Google Scholar 

  15. Contreras-Ruiz L, Ghosh-Mitra A, Shatos MA, Dartt DA, Masli S (2013) Modulation of conjunctival goblet cell function by inflammatory cytokines. Mediators Inflamm 2013:636812

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Dartt DA, Masli S (2014) Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation. Curr Opin Allergy Clin Immunol 14:464–470

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Paschides CA, Petroutsos G, Psilas K (1991) Correlation of conjunctival impression cytology results with lacrimal function and age. Acta Ophthalmol 69:422–425

    Article  CAS  Google Scholar 

  18. Versura P, Giannaccare G, Campos EC (2015) Sex-steroid imbalance in females and dry eye. Curr Eye Res 40:162–175

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Ophthalmology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey

    Nilay Yuksel

  2. Alacaatlı Mah. Sinpas Inceklife No:2/5, Ankara, Turkey

    Nilay Yuksel

  3. Department of Ophthalmology, Ankara Ataturk Education and Research Hospital, Yildirim Beyazit University, Ankara, Turkey

    Melek Mutlu & Emine Akcay

  4. Department of Pathology, Ankara Ataturk Education and Research Hospital, Yildirim Beyazit University, Ankara, Turkey

    Aydan Kilicarslan

Authors
  1. Nilay Yuksel
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  2. Melek Mutlu
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  3. Aydan Kilicarslan
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  4. Emine Akcay
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Corresponding author

Correspondence to Nilay Yuksel.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Yuksel, N., Mutlu, M., Kilicarslan, A. et al. Conjunctival cytologic features in patients with unilateral primary acquired nasolacrimal duct obstruction. Int Ophthalmol 38, 323–326 (2018). https://doi.org/10.1007/s10792-017-0471-0

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  • DOI: https://doi.org/10.1007/s10792-017-0471-0

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