Peripapillary retinal nerve fiber layer and ganglion cell–inner plexiform layer thickness in adult-onset familial Mediterranean fever
The purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell–inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF).
Forty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography. The patients were divided into two groups according to their disease severity score, M694V gene mutation, colchicine dosage used per day, colchicine usage time period and number of FMF attacks per year.
There were no statistically significant differences in peripapillary RNFL and retinal GCIPL thickness in patients with adult-onset FMF and controls.
According to our study, it looks like that neither adult-onset FMF nor colchicine has any effect on the RNFL and GCIPL thicknesses. Further studies with a large sample size are needed.
KeywordsColchicine Disease severity score M694V gene mutation Ganglion cell–inner plexiform layer thickness Retinal nerve fiber layer thickness Optical coherence tomography
Authors are grateful to Mr. Osman DEMİR, Instructor (Gaziosmanpaşa University, School of Medicine, Department of Biostatistics) for his support in statistics of the present study.
Compliance with ethical standards
Conflict of interest
This study has no financial support, and the authors report no declarations of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standard.
Informed consent was obtained from all individual participants included in the study.
- 4.Sayarlioglu M, Cefle A, Inanc M, Kamali S, Dalkilic E, Gul A, Ocal L, Aral O, Konice M (2005) Characteristics of patients with adult-onset familial Mediterranean fever in Turkey: analysis of 401 cases a survey of 470 cases and review of the literature. Int J Clin Pract 59:202–205CrossRefPubMedGoogle Scholar
- 16.Nakazawa T, Nakazawa C, Matsubara A, Noda K, Hisatomi T, She H, Michaud N, Hafezi-Moghadam A, Miller JW, Benowitz LI (2006) Tumor necrosis factor-alpha mediates oligodendrocytes death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J Neurosci 26:12633–12641CrossRefPubMedGoogle Scholar