International Ophthalmology

, Volume 38, Issue 1, pp 163–169 | Cite as

Visual outcome and refractive status in first 3 years of age in preterm infants suffered from laser-treated Type 1 retinopathy of prematurity (ROP): a 6-year retrospective review in a tertiary centre in Hong Kong

  • Julie Y. C. Lok
  • Wilson W. K. Yip
  • Abbie S. W. Luk
  • Joyce K. Y. Chin
  • Henry H. W. Lau
  • Alvin L. Young
Original Paper



To report the visual outcome and refractive status in first 3 years of age in preterm infants suffered from laser-treated Type 1 retinopathy of prematurity (ROP): a 6-year review in Hong Kong


Retrospective case series


Clinical records of all infants suffered from Type 1 ROP who had undergone laser therapy between 2007 and 2012 were retrospectively reviewed. Basic demographic data, serial changes of refractive error, visual acuity, severity of ROP and laser were analyzed. Correlation with myopia and astigmatism progression, body weight, height, growth and gestational age were also analyzed.


Among 494 babies screened, 14 Chinese babies (26 eyes) recruited with 1:1 male-to-female ratio in this study. All eyes showed gradual progression of myopia in first 3 years of age but no significant change of astigmatism. Further correlation analysis showed no correlation with laser energy consumed, birth weight (p = 0.14), head circumference growth (p = 0.57) and body weight growth (p = 0.71). However, severity of myopia was related to the post-conceptual age when receiving laser therapy (p < 0.005), gestation age (p = 0.02) and possibly body height growth with age (p = 0.05).


Myopia in early life is one of the most common ocular sequelae in Type 1 ROP survivors. Early detection of refractive error is important for prompt correction and visual rehabilitation to prevent amblyopia.


Retinopathy of prematurity Myopia Laser Late sequelae Refractive error 


Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to declare.

Ethical standards

This protocol is compliance with the Declaration of Helsinki.


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Julie Y. C. Lok
    • 1
  • Wilson W. K. Yip
    • 1
  • Abbie S. W. Luk
    • 1
  • Joyce K. Y. Chin
    • 1
  • Henry H. W. Lau
    • 1
  • Alvin L. Young
    • 1
  1. 1.Department of Ophthalmology and Visual SciencesThe Chinese University of Hong Kong, Prince of Wales HospitalShatinHong Kong

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