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Alterations in corneal epithelial thickness in patients with congenital myogenic eyelid ptosis

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Abstract

Purpose

To evaluate whether the corneal epithelial thickness (CET) maps obtained by optical coherence tomography (OCT) of the congenital myogenic eyelid ptosis differ from controls.

Methods

CET maps of 13 patients with congenital myogenic eyelid ptosis (m/f = 9/4; mean age 20.5 ± 7.5) and randomly selected one eye of 13 controls (m/f = 7/6; mean age 21.5 ± 6.5) were investigated. Three pachymetry scans of each eye were performed by OCT (RTVue-XR, Optovue Inc., USA), and the scan with the highest signal strength index was selected for the analysis.

Results

In ptosis group: Minimum corneal epithelial thickness was thinner (p = 0.029), standard deviation of thickness was higher (p = 0.039), the negative of min–max values were higher (p = 0.007). This difference was originating from the significant thinness of the superior sectors (S, SN, ST) of the corneal epithelium than the inferior counterparts (I, IT, IN) (p = 0.001, p = 0.017, p = 0.002), respectively. There was no difference regarding total corneal thickness measurements.

Conclusions

The mechanic effects of ptotic eyelid to the ocular surface may reshape the corneal epithelium, which can be objectively detected by OCT.

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References

  1. SooHoo JR, Davies BW, Allard FD et al (2014) Congenital ptosis. Surv Ophthalmol 59:483–492

    Article  PubMed  Google Scholar 

  2. Finsterer J (2003) Ptosis: causes, presentation, and management. Aesthet Plast Surg 27:193–204

    Article  Google Scholar 

  3. Hu DN (1987) Prevalence and mode of inheritance of major genetic eye diseases in China. J Med Genet 24:584–588

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Griepentrog GJ, Diehl NN, Mohney BG (2011) Incidence and demographics of childhood ptosis. Ophthalmology 118:1180–1183

    Article  PubMed Central  PubMed  Google Scholar 

  5. Lu L, Reinach PS, Kao WW (2001) Corneal epithelial wound healing. Exp Biol Med 226:653–664 (Maywood)

    Article  CAS  Google Scholar 

  6. Yang Y, Hong J, Deng SX et al (2014) Age-related changes in human corneal epithelial thickness measured with anterior segment optical coherence tomography. Investig Ophthalmol Vis Sci 55:5032–5038

    Article  Google Scholar 

  7. Li HF, Petroll WM, Møller-Pedersen T et al (1997) Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF). Curr Eye Res 16:214–221

    Article  CAS  PubMed  Google Scholar 

  8. Reinstein DZ, Archer TJ, Gobbe M et al (2008) Epithelial thickness in the normal cornea: three-dimensional display with Artemis very high-frequency digital ultrasound. J Refract Surg 24:571–581

    PubMed Central  PubMed  Google Scholar 

  9. Kanellopoulos AJ, Asimellis G (2013) In vivo three-dimensional corneal epithelium imaging in normal eyes by anterior-segment optical coherence tomography: a clinical reference study. Cornea 32:1493–1498

    Article  PubMed  Google Scholar 

  10. Temstet C, Sandali O, Bouheraoua N et al (2015) Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus. J Cataract Refract Surg 41:812–820

    Article  PubMed  Google Scholar 

  11. Pérez-Iñigo MA, González I, Mayoral F et al (2008) Comparative study of refractive errors in simple congenital myogenic ptosis and control children. Arch Soc Esp Oftalmol 83:601–606

    Article  PubMed  Google Scholar 

  12. Savino G, Battendieri R, Riso M et al (2016) Corneal topographic changes after eyelid ptosis surgery. Cornea 35:501–505

    Article  PubMed  Google Scholar 

  13. Nieto-Bona A, González-Mesa A, Nieto-Bona MP et al (2011) Short-term effects of overnight orthokeratology on corneal cell morphology and corneal thickness. Cornea 30:646–654

    Article  PubMed  Google Scholar 

  14. Qian Y, Xue F, Huang J et al (2014) Pachymetry map of corneal epithelium in children wearing orthokeratology contact lenses. Curr Eye Res 39:263–270

    Article  PubMed  Google Scholar 

  15. Haque S, Jones L, Simpson T (2008) Thickness mapping of the cornea and epithelium using optical coherence tomography. Optom Vis Sci 85:E963–E976

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Ophthalmology, Ministry of Health, Diskapi Yildirim Beyazit Training and Research Hospital, Irfan Baştuğ Cad. Dışkapı, 06130, Ankara, Turkey

    Aysun Sanal Dogan, Mutlu Acar, Mustafa Kosker, Nese Arslan & Canan Gurdal

Authors
  1. Aysun Sanal Dogan
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  2. Mutlu Acar
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  3. Mustafa Kosker
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  4. Nese Arslan
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  5. Canan Gurdal
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Corresponding author

Correspondence to Aysun Sanal Dogan.

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The authors declare that they have no conflict of interest.

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Dogan, A.S., Acar, M., Kosker, M. et al. Alterations in corneal epithelial thickness in patients with congenital myogenic eyelid ptosis. Int Ophthalmol 38, 53–57 (2018). https://doi.org/10.1007/s10792-016-0419-9

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  • DOI: https://doi.org/10.1007/s10792-016-0419-9

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