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Multimodal imaging in a case of bilateral outer retinitis associated with mumps infection

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Abstract

Purpose

To report the results of multimodal imaging of acute outer retinitis associated to mumps infection.

Methods

A patient with mumps-associated outer retinitis evaluated by color fundus photography, spectral domain optical coherence tomography (SD-OCT), optical coherence tomography angiography, fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography (ICGA).

Results

We report a case of a 12-year-old boy who developed bilateral outer retinitis related to mumps. Ophthalmoscopy showed confluent areas of outer retinitis involving the posterior pole and the periphery with a centrifugal gyrate pattern. SD-OCT revealed a marked disorganization of the outer retinal layers with multiple highly reflective spicules. FA shows diffuse late hyperfluorescence with optic disk staining. ICGA shows macular and peripheral hyperfluorescent lesions with a geographical pattern in the late phases. The patient was treated with acyclovir and oral prednisone. Four weeks after presentation visual acuity remained unchanged, and retinal changes seen at the acute phase had resolved leading to extensive retinal atrophy and optic disk pallor. SD-OCT showed atrophy of the retinal pigment epithelial and outer retinal layers. FAF revealed scattered hyperautofluorescent lesions. Electrophysiology showed generalized retinal dysfunction.

Conclusions

Mumps infection should be considered in the differential diagnosis of bilateral necrotizing outer retinitis in children and young adults. A multimodal imaging approach may help distinguish mumps-associated retinitis from other causes of viral retinitis and facilitate appropriate management.

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References

  1. Rubin S, Eckhaus M, Rennick LJ, Bamford CG, Duprex WP (2015) Molecular biology, pathogenesis and pathology of mumps virus. J Pathol 235:242–252

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Trehan HS, Sheth SS, Mathai A, Reddy RK, Moorthy RS (2010) Diagnostic and therapeutic challenges. Retina 30:180–183

    Article  PubMed  Google Scholar 

  3. Babu K, Md Mrcophth Lon, De C, Sampangi R (2016) Bilateral outer retinal necrosis following mumps infection. Ocul Immunol Inflamm. 1–3

  4. Riffenburgh RS (1961) Ocular manifestations of mumps. Arch Ophthalmol 66:739–743

    Article  CAS  PubMed  Google Scholar 

  5. Shibata T, Takahashi Y, Okamoto A, Sasaki H, Kitagawa K (2016) An adult case of fulminant mumps keratitis with positive viral RNA in aqueous humor detected by RT-PCR. Cornea 35:569–571

    Article  PubMed  Google Scholar 

  6. Ando K, Ishihara M, Kusumoto Y, Shibuya E, Nakamura S, Mizuki N (2013) A case of corneal endotheliitis with mumps virus RNA in aqueous humor detected by rt-PCR. Ocul Immunol Inflamm 21:150–152

    Article  PubMed  Google Scholar 

  7. Onal S, Toker E (2005) A rare ocular complication of mumps: kerato-uveitis. Ocul Immunol Inflamm 13:395–397

    Article  PubMed  Google Scholar 

  8. Slagsvold JE. Acute ocular hypotony as a manifestation of mumps. A case report (1980) Acta Ophthalmol (Copenh). 58:288–291

  9. Al-Rashid RA, Cress C (1977) Mumps uveitis complicating the course of acute leukemia. J Pediatr Ophthalmol 14:100–102

    CAS  PubMed  Google Scholar 

  10. Polland W, Thorburn W (1976) Transient glaucoma as a manifestation of mumps. A case report (1976) Acta Ophthalmol (Copenh) 54:779–782

  11. Irioka T, Akaza M, Nakao K, Kanouchi T, Yokota T, Mizusawa H (2008) Chiasmal optic neuritis following mumps parotitis. J Neurol 255:773–774

    Article  PubMed  Google Scholar 

  12. Foster RE, Lowder CY, Meisler DM, Kosmorsky GS, Baetz-Greenwalt B (1990) Mumps neuroretinitis in an adolescent. Am J Ophthalmol 110:91–93

    Article  CAS  PubMed  Google Scholar 

  13. Borruat FX, Piguet B, Herbort C (1998) Acute posterior multifocal placoid pigment epitheliopathy following mumps. Ocul Immunol Inflamm 6:189–193

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work has been supported by the Ministry of Higher Education and Research of Tunisia.

Conflict of interest

The authors declare that they have no conflict of interest. No disclosure of funding.

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Authors and Affiliations

  1. Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, 5019, Monastir, Tunisia

    Rim Kahloun, Hager Ben Amor, Imen Ksiaa, Sourour Zina, Bechir Jelliti, Salim Ben Yahia & Moncef Khairallah

Authors
  1. Rim Kahloun
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  2. Hager Ben Amor
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  3. Imen Ksiaa
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  4. Sourour Zina
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  5. Bechir Jelliti
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  6. Salim Ben Yahia
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  7. Moncef Khairallah
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Corresponding author

Correspondence to Moncef Khairallah.

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Kahloun, R., Ben Amor, H., Ksiaa, I. et al. Multimodal imaging in a case of bilateral outer retinitis associated with mumps infection. Int Ophthalmol 38, 339–343 (2018). https://doi.org/10.1007/s10792-016-0417-y

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  • DOI: https://doi.org/10.1007/s10792-016-0417-y

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