Abstract
The purpose of this study is to report the intermediate-term surgical outcomes of patients with iridocorneal endothelial syndrome-related glaucoma. The medical records of four patients (five eyes) surgery (Ahmed glaucoma valve implantation surgery and EX-PRESS mini shunt) were retrospectively reviewed. Median follow-up after glaucoma surgery was 24 (15–36) months. The preoperative intraocular pressure was significantly reduced from a median of 33 (22.5–36) mmHg on a median of 4 (4–5) glaucoma medications to a median of 12 (10.5–14.5) mmHg on a median of 2 (0–2) medications at last follow-up after surgery (p = 0.043 for IOP and p = 0.042 for glaucoma medications). Median preoperative visual acuity [0.016 (0.008–0.1)] did not change significantly when compared to median visual acuity at last follow-up [0.016 (0.004–0.5)] (p = 0.59). Intraocular pressure control in patients with iridocorneal endothelial syndrome is challenging and may require multiple operations and revisions. Some modifications during glaucoma drainage implant surgery and use of EX-PRESS mini shunt in certain cases could offer an advantage in these patients.
Similar content being viewed by others
References
Zhang M, Chen J, Liang L, Laties AM, Liu Z (2006) Ultrasound biomicroscopy of Chinese eyes with iridocorneal endothelial syndrome. Br J Ophthalmol 90(1):64–69
Doe EA, Budenz DL, Gedde SJ, Imami NR (2001) Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. Ophthalmology 108(10):1789–1795
Shields MB, Campbell DG, Simmons RJ (1978) The essential iris atrophies. Am J Ophthalmol 85(6):749–759
Hirst LW, Quigley HA, Stark WJ, Shields NB (1980) Specular microscopy of irido-corneal endothelial syndrome. Aust J Ophthalmol 8(2):139–146
Laganowski HC, Kerr Muir MG, Hitchings RA (1992) Glaucoma and the iridocorneal endothelial syndrome. Arch Ophthalmol 110(3):346–350
Kidd M, Hetherington J, Magee S (1988) Surgical results in iridocorneal endothelial syndrome. Arch Ophthalmol 106(2):199–201
Kim DK, Aslanides IM, Schmidt CM Jr, Spaeth GL, Wilson RP, Augsburger JJ (1999) Long-term outcome of aqueous shunt surgery in ten patients with iridocorneal endothelial syndrome. Ophthalmology 106(5):1030–1034
Sacchetti M, Mantelli F, Marenco M, Macchi I, Ambrosio O, Rama P (2015) Diagnosis and management of ıridocorneal endothelial syndrome. Biomed Res Int. doi:10.1155/2015/763093
Lanzl IM, Wilson RP, Dudley D, Augsburger JJ, Aslanides IM, Spaeth GL (2000) Outcome of trabeculectomy with mitomycin-C in the iridocorneal endothelial syndrome. Ophthalmology 107(2):295–297
Wilson MC, Shields MB (1989) A comparison of the clinical variations of the iridocorneal endothelial syndrome. Arch Ophthalmol 107(10):1465–1468
Hemady RK, Patel A, Blum S, Nirankari VS (1994) Bilateral iridocorneal endothelial syndrome: case report and review of the literature. Cornea 13(4):368–372 Review
Huna R, Barak A, Melamed S (1996) Bilateral iridocorneal endothelial syndrome presented as Cogan-Reese and Chandler’s syndrome. J Glaucoma 5(1):60–62
Blair SD, Seabrooks D, Shields WJ, Pillai S, Cavanagh HD (1992) Bilateral progressive essential iris atrophy and keratoconus with coincident features of posterior polymorphous dystrophy: a case report and proposed pathogenesis. Cornea 11(3):255–261
Kugu S, Erdogan G, Sevim MS, Ozerturk Y (2015) Efficacy of long scleral tunnel technique in preventing Ahmed glaucoma valve tube exposure through conjunctiva. Semin Ophthalmol 30(1):1–5
Tamaki R, Zako M (2014) Interference of descemet’s membrane with aqueous humor drainage via an ExPRESS mini shunt. Case Rep Ophthalmol 5(3):343–346
Chandran P, Rao HL, Mandal AK, Choudhari NS, Garudadri CS, Senthil S (2015) Outcomes of primary trabeculectomy with mitomycin-c in glaucoma secondary to ıridocorneal endothelial syndrome. J Glaucoma 25(7):e652–e656
Eagle RC Jr, Font RL, Yanoff M, Fine BS (1979) Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome. Arch Ophthalmol 97(11):2104–2111
Patel A, Kenyon KR, Hirst LW, Quigley HA, Stark WJ, Meyer RF, Green WR (1983) Clinicopathologic features of Chandler’s syndrome. Surv Ophthalmol 27(5):327–344 Review
Shaarawy T, Goldberg I, Fechtner R (2015) EX-PRESS glaucoma filtration device: review of clinical experience and comparison with trabeculectomy. Surv Ophthalmol 60(4):327–345
Yonker Jason M, Juzych Mark S (2007) Iridocorneal endothelial syndrome. Glaucoma today, Bryn Mawr Communications, Wayne
Hau S, Barton K (2009) Corneal complications of glaucoma surgery. Curr Opin Ophthalmol 20(2):131–136
Topouzis F, Coleman AL, Choplin N, Bethlem MM, Hill R, Yu F, Panek WC, Wilson MR (1999) Follow-up of the original cohort with the Ahmed glaucoma valve implant. Am J Ophthalmol 128(2):198–204
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
No conflicting relationship exists for any author.
Rights and permissions
About this article
Cite this article
Imamoglu, S., Sevim, M.S., Yıldız, H.E. et al. Surgical outcomes of patients with iridocorneal endothelial syndrome: a case series. Int Ophthalmol 37, 607–613 (2017). https://doi.org/10.1007/s10792-016-0317-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10792-016-0317-1