Skip to main content

Advertisement

SpringerLink
Log in

Activation of toxoplasma retinochoroiditis during pregnancy and evaluation of ocular findings in newborns

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

The purpose of this study was to evaluate patients with activation of toxoplasma retinochoroiditis during pregnancy and ocular findings in newborns. A total of 17 pregnant patients who were clinically and serologically diagnosed with ocular toxoplasmosis were retrospectively reviewed. After birth, ocular findings for all infants were recorded. The mean age of the patients was 29.08 ± 5.71 years. In all cases, activation was present in only one eye. In 13 cases, anterior uveitis was associated with posterior uveitis. Visual acuity in all cases prior to treatment was 0.3 ± 0.21 and increased to 0.55 ± 0.29 after treatment. The mean gestational age of the patients was 19.76 ± 8.71 weeks at the time of hospital admission. No case of toxoplasmic ocular involvement was identified in the infants on postnatal examination. In the case of toxoplasma retinochoroiditis during pregnancy, appropriate treatment and follow-up is very important to protect the newborns and to prevent impaired vision in mothers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Türkcü FM, Yüksel H, Cingü AK, Çınar Y, Şahin M, Özkurt Z, Murat M, Şahin A, Çaça İ (2013) Demographic and etiologic features of adult patients with uveitis in southeastern Anatolia. Dicle Med J 40:605–610

    Article  Google Scholar 

  2. Tugal-Tutkun I, Corum I, Otuk B, Urgancioglu M (2005) Active ocular toxoplasmosis in Turkish patients: a report on 109 cases. Int Ophthalmol 26:221–228

    Article  PubMed  Google Scholar 

  3. de-la-Torre A, Lopez-Castillo CA, Rueda JC, Mantilla RD, Gómez-Marín JE, Anaya JM (2009) Clinical patterns of uveitis in two ophthalmology centres in Bogota, Colombia. Clin Exp Ophthalmol 37:458–466

    Article  PubMed  Google Scholar 

  4. Garweg JG, Scherrer J, Wallon M, Kodjikian L, Peyron F (2005) Reactivation of ocular toxoplasmosis during pregnancy. BJOG 112:241–242

    Article  PubMed  Google Scholar 

  5. Petersen E, Kijlstra A, Stanford M (2012) Epidemiology of ocular toxoplasmosis. Ocul Immunol Inflamm 20:68–75

    Article  PubMed  Google Scholar 

  6. Torgerson PR, Mastroiacovo P (2013) The global burden of congenital toxoplasmosis: a systematic review. Bull World Health Organ 91:501–508

    Article  PubMed  PubMed Central  Google Scholar 

  7. McAuley J, Boyer KM, Patel D, Mets M, Swisher C, Roizen N, Wolters C, Stein L, Stein M, Schey W et al (1994) Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Infect Dis 18:38–72

    Article  CAS  PubMed  Google Scholar 

  8. Berrébi A, Assouline C, Bessières MH, Lathière M, Cassaing S, Minville V, Ayoubi JM (2010) Long-term outcome of children with congenital toxoplasmosis. Am J Obstet Gynecol 203:552

    Article  PubMed  Google Scholar 

  9. Wilson CB, Remington JS, Stagno S, Reynolds DW (1980) Development of adverse sequelae in children born with subclinical congenital toxoplasma infection. Pediatrics 66:767–774

    CAS  PubMed  Google Scholar 

  10. Silveira C, Ferreira R, Muccioli C, Nussenblatt R, Belfort R Jr (2003) Toxoplasmosis transmitted to a newborn from the mother infected 20 years earlier. Am J Ophthalmol 136:370–371

    Article  PubMed  Google Scholar 

  11. Ertug S, Okyay P, Turkmen M, Yuksel H (2005) Seroprevalence and risk factors for toxoplasma infection among pregnant women in Aydin province, Turkey. BMC Public Health 15:66

    Article  Google Scholar 

  12. Kump LI, Androudi SN, Foster CS (2005) Ocular toxoplasmosis in pregnancy. Clin Exp Ophthalmol 33:455–460

    Article  PubMed  Google Scholar 

  13. Harma M, Harma M, Gungen N, Demir N (2004) Toxoplasmosis in pregnant women in Sanliurfa, Southeastern Anatolia City, Turkey. J Egypt Soc Parasitol 34:519–525

    PubMed  Google Scholar 

  14. Ocak S, Zeteroglu S, Ozer C, Dolapcioglu K, Gungoren A (2007) Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in southern Turkey. Scand J Infect Dis 39:231–234

  15. Braakenburg AM, Rothova A (2009) Clinical features of ocular toxoplasmosis during pregnancy. Retina 29:627–630

    Article  PubMed  Google Scholar 

  16. Friedmann CT, Knox DL (1969) Variations in recurrent active toxoplasmic retinochoroiditis. Arch Ophthalmol 81:481–493

    Article  CAS  PubMed  Google Scholar 

  17. O’Connor GR (1983) Factors related to the initiation and recurrence of uveitis. XL Edward Jackson memorial lecture. Am J Ophthalmol 96:577–599

    Article  PubMed  Google Scholar 

  18. Chan CC, Reed GF, Kim Y, Agrón E, Buggage RR (2004) A correlation of pregnancy term, disease activity, serum female hormones, and cytokines in uveitis. Br J Ophthalmol 88:1506–1509

    Article  PubMed  PubMed Central  Google Scholar 

  19. Reich M, Ruppenstein M, Becker MD, Mackensen F (2014) Risk of recurrence of preexisting ocular toxoplasmosis during pregnancy. Ocul Immunol Inflamm 9:1–6

    Google Scholar 

  20. Holland GN (1989) Ocular toxoplasmosis in the immunocompromised host. Int Ophthalmol 13:399–402

    Article  CAS  PubMed  Google Scholar 

  21. Dunn D, Wallon M, Peyron F, Petersen E, Peckham C, Gilbert R (1999) Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling. Lancet 353:1829–1833

    Article  CAS  PubMed  Google Scholar 

  22. Montoya JG, Kovacs JA, Remington JS (2005) Toxoplasma gondii. In: Mandell GL, Bennett JE, Dolin R (eds) Principles and pratice of infectious disease, 6th edn. Elsevier Churchill Livingstone, Philedelphia, pp 3170–3198

    Google Scholar 

  23. Bosch-Driessen LH, Karimi S, Stilma JS, Rothova A (2000) Retinal detachment in ocular toxoplasmosis. Ophthalmology 107:36–40

    Article  CAS  PubMed  Google Scholar 

  24. Engstrom RE, Holland GN, Nussenblatt RB, Jabs DA (1991) Current practices in the management of ocular toxoplasmosis. Am J Ophthalmol 111:601–610

    Article  PubMed  Google Scholar 

  25. Delair E, Monnet D, Grabar S, Dupouy-Camet J, Yera H, Brézin AP (2008) Respective roles of acquired and congenital infections in presumed ocular toxoplasmosis. Am J Ophthalmol 146:851–855

    Article  PubMed  Google Scholar 

  26. Kodjikian L, Wallon M, Fleury J, Denis P, Binquet C, Peyron F, Garweg JG (2006) Ocular manifestations in congenital toxoplasmosis. Graefes Arch Clin Exp Ophthalmol 244:14–21

    Article  PubMed  Google Scholar 

  27. Martinez CE, Zhang D, Conway MD, Peyman GA (1998) Successful management of ocular toxoplasmosis during pregnancy using combined intraocular clindamycin and dexamethasone with systemic sulfadiazine. Int Ophthalmol 22:85–88

    Article  PubMed  Google Scholar 

  28. de Jong PT (1989) Congenital toxoplasmosis: common and rare symptomsand signs. Int Ophthalmol 13:391–397

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Dicle University, Sur, Diyarbakir, Turkey

    Fatih Mehmet Türkcü, Alparslan Şahin, Harun Yüksel, Yasin Çınar, Kürşat Cingü, Suat Altındağ, Zeynep Özkurt & İhsan Çaça

  2. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey

    Özcan Deveci

Authors
  1. Fatih Mehmet Türkcü
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alparslan Şahin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Harun Yüksel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yasin Çınar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kürşat Cingü
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Suat Altındağ
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Özcan Deveci
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Zeynep Özkurt
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. İhsan Çaça
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fatih Mehmet Türkcü.

Ethics declarations

Conflict of interest

The authors report that there are no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Türkcü, F.M., Şahin, A., Yüksel, H. et al. Activation of toxoplasma retinochoroiditis during pregnancy and evaluation of ocular findings in newborns. Int Ophthalmol 37, 559–563 (2017). https://doi.org/10.1007/s10792-016-0311-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-016-0311-7

Keywords

Search

Navigation