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Reproducibility of choroidal thickness measurements in subjects on 3 spectral domain optical coherence tomography machines

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Abstract

The purpose of this study was to investigate the reproducibility of choroidal thickness measurements in normal subjects on 3 spectral domain optical coherence tomography instruments, namely: Zeiss Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA), Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany), and Optovue RTVue (Optovue Inc., Fremont, CA). This cross-sectional non-interventional study was performed in a single institution. Images were obtained in 47 eyes of 47 healthy volunteers which age ranged between 23 and 72 without ocular pathology. All subjects were imaged on the fovea using Cirrus HD 1-line raster, Spectralis enhanced depth imaging, and RTVue retina-cross. The choroid was measured subfoveally and at intervals of 500 µm from the fovea nasally and temporally up to 2500 µm. Paired t test, modified Bland–Altman plot, and Pearson’s correlation were used to compare the results. There is no significant difference between the systems for any measurement within 2500 µm either side of the fovea for most points. Inter-observer correlation was strong for RTVue, and moderate in both Cirrus and Spectralis.

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Acknowledgments

This work was supported by the University of Malaya under the Research Grant Number RP006F-13HTM. The authors would like to thank Jie Ming Yeo for editing the manuscript and Choung Min Ng for providing statistical data.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia

    Chiang Ling Koay & Visvaraja Subrayan

  2. University of Western Australia, Crawley, Australia

    Matthew Justin Quo

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  1. Chiang Ling Koay
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  2. Matthew Justin Quo
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  3. Visvaraja Subrayan
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Correspondence to Chiang Ling Koay.

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Koay, C.L., Quo, M.J. & Subrayan, V. Reproducibility of choroidal thickness measurements in subjects on 3 spectral domain optical coherence tomography machines. Int Ophthalmol 37, 655–671 (2017). https://doi.org/10.1007/s10792-016-0306-4

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  • DOI: https://doi.org/10.1007/s10792-016-0306-4

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