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Intraocular pressure in infants and its association with hormonal changes with vaginal birth versus cesarean section

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Abstract

To investigate cord arterial blood sample and the relationship between birth stress and intraocular pressure in infants at 5 min after delivery. The IOP measurements were taken using Tonopen-Avia tonometer to 158 newborns (158 eyes) at 5th min after birth, in a university hospital. Cord blood was collected within 3 min after delivery. Intraocular pressure, gender, gestation period, mode of delivery, and birth weight of newborns were noted from medical records. Sixty-two babies were delivered by normal vaginal delivery (NVD) and 96 by cesarian section (C/S). Mean IOP of NVD and C/S groups were 19.56 ± 3.84 and 17.42 ± 3.50, respectively. There was significant difference of mean IOP between two groups. (p < 0.001) There were significant differences between two groups regarding APGAR score (p < 0.001) and cord blood adrenaline (p = 0.003), noradrenaline (p = 0.008), and cortisol (p < 0.001) levels. There was no difference between infant corneal thickness measurements (p = 0.698). In correlation analyses, there is a strong negative correlation between the labor type and postpartum measurements except corneal thickness. Correlation analyses of the 5th min intraocular pressure of the groups individually revealed significant correlation in the NVD group. The conclusion is that the intraocular pressure of newborn infants was higher in NVD delivery compare to C/S. Blood hormonal changes in different anesthesia types and physical stress was thought as the main reason of this result.

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References

  1. Chesnutt AN (2004) Physiology of normal pregnancy. Crit Care Clin 20:609–615

    Article  PubMed  Google Scholar 

  2. Carlin A, Alfirevic Z (2008) Physiological changes of pregnancy and monitoring. Best Pract Res Clin Obstet Gynaecol 22:801–823

    Article  PubMed  Google Scholar 

  3. Reddy SC, Alias R (2014) Tono-pen measurement of intraocular pressure under topical anaesthesia in full term normal newborns. Int J Ophthalmol 7:92–94

    PubMed  PubMed Central  Google Scholar 

  4. Karahan E, Zengin MO, Tuncer I, Zengin N (2015) Correlation of intraocular pressure with central corneal thickness in premature and full-term newborns. Eur J Ophthalmol 25:14–17

    Article  PubMed  Google Scholar 

  5. Lindenmeyer RL, Farias L, Mendonça T, Fortes Filho JB, Procianoy RS, Silveira RC (2012) Intraocular pressure in very low birth weight preterm infants an its association with postconceptional age. Clinics 67:1241–1245

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ng PC, Tam BS, Lee CH, Wong SP, Lam HS, Kwok AK et al (2008) A longitudinal study to establish the normative value and to evaluate perinatal factors affecting intraocular pressure in preterm infants. Invest Ophthalmol Vis Sci 49:87–92

    Article  PubMed  Google Scholar 

  7. Uva MG, Reibaldi M, Longo A, Avitabile T, Gagliano C, Scollo D et al (2011) Intraocular pressure and central corneal thickness in premature and full-term newborns. JAAPOS 15:367–369

    Google Scholar 

  8. Zengin N, Zengin MÖ, Karahan E, Tuncer İ (2014) Alterations in intraocular pressure and central corneal thickness in premature newborns. Behcet Uz Cocuk Hast Derg 4:20–24

    Article  Google Scholar 

  9. Irestedt L, Lagercrantz H, Hjemdahl P, Hägnevik K, Belfrage P (1982) Fetal and maternal plasma catecholamine levels at elective cesarean section under general or epidural anesthesia versus vaginal delivery. Am J Obstet Gynecol 142:1004–1010

    Article  CAS  PubMed  Google Scholar 

  10. Faxelius G, Lagercrantz H, Yao A (1984) Sympathoadrenal activity and peripheral blood flow after birth: comparison in infants delivered vaginally and by cesarean section. J Pediatr 105:144–148

    Article  CAS  PubMed  Google Scholar 

  11. Miller NM, Fisk NM, Modi N, Glover V (2005) Stress responses at birth: determinants of cord arterial cortisol and links with cortisol response in infancy. BJOG 112:921–926

    Article  CAS  PubMed  Google Scholar 

  12. Victoria NC, Murphy AZ (2015) The long-term impact of early life pain on adult responses to anxiety and stress: Historical perspectives and empirical evidence. Exp Neurol. doi:10.1016/j.expneurol.2015.07.017

    PubMed  Google Scholar 

  13. Miyazaki Y, Matsuo T, Kurabayashi Y (2000) Immobilization stress induces elevation of intraocular pressure in rabbits. Ophthalmic Res 32:270–277

    Article  CAS  PubMed  Google Scholar 

  14. Brody S, Erb C, Veit R, Rau H (1999) Intraocular pressure changes: the influence of psychological stress and the Valsalva maneuver. Biol Psychol 51:43–57

    Article  CAS  PubMed  Google Scholar 

  15. Shahid E, Shaikh A (2013) Effect of different eye speculums on intra ocular pressure. Effect of different eye speculums on intra ocular pressure. J Pak Med Assoc 63:1278–1280

    PubMed  Google Scholar 

  16. Gregory KD, Jackson S, Korst L, Fridman M (2012) Cesarean versus vaginal delivery: whose risks? Whose benefits? Am J Perinatol 29:7–18

    Article  PubMed  Google Scholar 

  17. Kass MA, Sears ML (1977) Hormonal regulation of intraocular pressure. Surv Ophthalmol 22:153–176

    Article  CAS  PubMed  Google Scholar 

  18. Razeghinejad MR, Katz LJ (2012) Steroid-induced iatrogenic glaucoma. Ophthalmic Res 47:66–80

    Article  CAS  PubMed  Google Scholar 

  19. Mikheytseva I, Lipovetskaya E, Kopp O, Mozaffarieh M, Grieshaber MC, Flammer J et al (2009) Adrenaline-induced chronic ocular hypertension in adult rabbits. Klin Monbl Augenheilkd 226:332–336

    Article  CAS  PubMed  Google Scholar 

  20. Fitzgerald PJ (2009) Is elevated noradrenaline an aetiological factor in a number of diseases? Auton Autacoid Pharmacol 29:143–156

    Article  CAS  PubMed  Google Scholar 

  21. Cunningham AJ, Barry P (1986) Intraocular pressure–physiology and implications for anaesthetic management. Can Anaesth Soc J 33:195–208

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This study was supported by Medical Device Companies for laboratory test expenses.

Author contributions

Involved in design and conduct of the study (AE, UC, OFO); preparation and review of the study (UC, BC, GK, NZK, BTB); data collection (AE, JCUA).

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Authors and Affiliations

  1. Department of Ophthalmology, Bezmialem University School of Medicine, Istanbul, Turkey

    Ahmet Elbay & Julide Canan Umurhan Akkan

  2. Department of Ophthalmology, Medeniyet University School of Medicine, Istanbul Medeniyet Üniversitesi Göztepe Eğitim Ve Araştırma Hastanesi. Göz Hastalıkları Servisi. Doktor Erkin Caddesi, Kadıköy, Istanbul, Turkey

    Ugur Celik

  3. Department of Ophthalmology, Haydarpasa Training and Research Hospital, Istanbul, Turkey

    Burcu Celik

  4. Department of Biochemistry, Bezmialem University School of Medicine, Istanbul, Turkey

    Omer Faruk Ozer

  5. Department of Obstetric and Gynecology, Bezmialem University School of Medicine, Istanbul, Turkey

    Gokhan Kilic

  6. Department of Pediatric Disease, Bezmialem University School of Medicine, Istanbul, Turkey

    Bilge Tanyeri Bayraktar

  7. Department of Ophthalmology, Dr. Lütfü Kırdar Kartal Training and Research Hospital, Istanbul, Turkey

    Nilufer Zorlutuna Kaymak

Authors
  1. Ahmet Elbay
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  2. Ugur Celik
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  3. Burcu Celik
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  4. Omer Faruk Ozer
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  6. Julide Canan Umurhan Akkan
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  7. Bilge Tanyeri Bayraktar
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  8. Nilufer Zorlutuna Kaymak
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Corresponding author

Correspondence to Ugur Celik.

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None of the authors has financial or proprietary interests in any material or method mentioned.

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Elbay, A., Celik, U., Celik, B. et al. Intraocular pressure in infants and its association with hormonal changes with vaginal birth versus cesarean section. Int Ophthalmol 36, 855–860 (2016). https://doi.org/10.1007/s10792-016-0215-6

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  • DOI: https://doi.org/10.1007/s10792-016-0215-6

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