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Prognosis of eyelid sebaceous gland carcinoma based on the tumor (T) category of the American Joint Committee on Cancer (AJCC) classification

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Abstract

The purpose of this study was to evaluate the clinical features and prognosis of eyelid sebaceous gland carcinoma (SGC) based on the T category of the American Joint Committee on Cancer (AJCC) classification (7th edition). This is a retrospective interventional case series study. Based on the T category of the AJCC classification, 191 patients with eyelid sebaceous gland carcinoma were classified as T1 (n = 1, 1 %), T2 (n = 111, 58 %), T3 (n = 76, 40 %), and T4 (n = 3, 2 %). Based on multivariate analysis, the factors predictive of regional lymph node metastasis included duration of symptoms >6 months (p = 0.04) and orbital tumor extension (p < 0.001). The factors predictive of systemic metastasis included orbital tumor extension (p < 0.001) and perivascular invasion (p = 0.007). The factor predictive of death due to systemic metastasis included orbital tumor extension (p < 0.001). Kaplan–Meier estimates of regional lymph node metastasis at 5 and 10 years, respectively, were 0 and 0 % for T1, 11 and 11 % for T2, 44 and 59 % for T3, and 100 and 100 % for T4 (p < 0.001). Kaplan–Meier estimates of systemic metastasis at 5 and 10 years, respectively, were 0 and 0 % for T1, 6 and 6 % for T2, 35 and 35 % for T3, and 100 and 100 % for T4 (p < 0.001). Kaplan–Meier estimates of death due to metastasis at 5 and 10 years, respectively, were 0 and 0 % for T1, 3 and 3 % for T2, 30 and 50 % for T3, and 100 and 100 % for T4 (p < 0.001). Primary tumor (T) category of the AJCC classification predicts the prognosis of patients with eyelid SGC. The risk of systemic metastasis and death increases with increasing tumor category.

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Acknowledgments

The authors acknowledge the support provided by The Operation Eyesight Universal Institute for Eye Cancer (SK) and Hyderabad Eye Research Foundation, Hyderabad, India (SK). The funders had no role in the preparation, review or approval of the manuscript. The authors are also grateful to Mohammed Hasnat Ali, MBA, Center for Clinical Epidemiology and Bio-statistics, L. V. Prasad Eye Institute, Hyderabad, India, for providing the statistical analysis data.

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Authors and Affiliations

  1. The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, 500034, India

    Swathi Kaliki, Adit Gupta, Anuradha Ayyar & Milind N. Naik

  2. Center for Clinical Epidemiology and Bio-Statistics (MHA), L V Prasad Eye Institute, Hyderabad, India

    Mohammed Hasnat Ali

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  1. Swathi Kaliki
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  2. Adit Gupta
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  3. Mohammed Hasnat Ali
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  4. Anuradha Ayyar
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  5. Milind N. Naik
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Correspondence to Swathi Kaliki.

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In this study of 191 patients with eyelid sebaceous gland carcinoma, Kaplan-Meier estimate of systemic metastasis at 5 years based on T category of AJCC staging was 0 % for T1, 6 % for T2, 35 % for T3, and 100 % for T4 (p < 0.001).

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Kaliki, S., Gupta, A., Ali, M.H. et al. Prognosis of eyelid sebaceous gland carcinoma based on the tumor (T) category of the American Joint Committee on Cancer (AJCC) classification. Int Ophthalmol 36, 681–690 (2016). https://doi.org/10.1007/s10792-016-0187-6

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  • DOI: https://doi.org/10.1007/s10792-016-0187-6

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