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The macular findings on spectral-domain optical coherence tomography in premature infants with or without retinopathy of prematurity

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Abstract

The purpose of the study was to present spectral-domain optical coherence tomography (OCT) findings in premature infants with or without mild-to-severe retinopathy of prematurity (ROP). Seventy-two infants born <37 weeks of gestation were analyzed, prospectively. Group 1 (n = 18) included infants without ROP. Infants with stage 1, 2, or 3 ROP without indication for treatment formed the second group (n = 15). Group 3 (n = 21) included threshold cases, who would receive laser photocoagulation (LPC) after OCT examinations. Group 4 (n = 18) had already received LPC. The mean central foveal thickness (CFT) (μm) in right eyes was 194.27 ± 19.93, 207.67 ± 25.44, 224.29 ± 21.42, and 222.00 ± 37.80, for groups 1, 2, 3, and 4, respectively (p = 0.01). The presence of a well-formed foveal pit was documented in 60 % of right and 67 % of left eyes in group 1, while a well-formed foveal pit was observed in 14 % of right and 16 % of left eyes in group 3 (p < 0.05). Cystoid macular edema (CME) was shown in 29 % of right and 21 % of left eyes in group 3 (p < 0.05 for right eyes). CME was observed in two of right and left eyes in group 4. Epiretinal membrane (ERM) was shown in one right eye in group 3, two right and four left eyes in group 4 (p < 0.05 for left eyes). Thicker CFT, CME, and failure of a well-formed foveal pit could be related to the severity of ROP. The development of ERM could be the consequence of LPC.

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Acknowledgments

This study was supported by the Eskişehir Osmangazi University Scientific Research Project (Project number: 2013-99) Commission. The supporting source had no involvement in the study design; the collection, analysis, and interpretation of the data; the writing of the report; or the decision to submit the report for publication.

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Authors and Affiliations

  1. Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Meselik, Eskisehir, Turkey

    Huseyin Gursoy, Mustafa Deger Bilgec, Nazmiye Erol & Hikmet Basmak

  2. Department of Biostatistics, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

    Ertugrul Colak

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  1. Huseyin Gursoy
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  2. Mustafa Deger Bilgec
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  3. Nazmiye Erol
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  4. Hikmet Basmak
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Correspondence to Huseyin Gursoy.

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Gursoy, H., Bilgec, M.D., Erol, N. et al. The macular findings on spectral-domain optical coherence tomography in premature infants with or without retinopathy of prematurity. Int Ophthalmol 36, 591–600 (2016). https://doi.org/10.1007/s10792-016-0176-9

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  • DOI: https://doi.org/10.1007/s10792-016-0176-9

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