Skip to main content

Advertisement

SpringerLink
Log in

Anterior chamber aqueous flare, pseudoexfoliation syndrome, and glaucoma

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

The purpose of this study is to evaluate anterior chamber aqueous flare (ACAF) in Tunisian patients with pseudoexfoliation (PEX) syndrome with or without associated glaucoma. This is a prospective, cross-sectional, comparative study including 53 patients (88 eyes) with PEX syndrome, 48 patients with PEX glaucoma (86 eyes), and 53 healthy sex-and age-matched control subjects (106 eyes). All patients underwent a complete ophthalmic examination and laser flare photometry. Mean ACAF was significantly higher in the PEX syndrome group in comparison with the control group (17.96 ± 10.05 vs 7.06 ± 2.95 ph/ms; p = 10−4), in patients with PEX glaucoma compared to PEX syndrome without associated glaucoma (27.99 ± 15.45 vs 17.96 ± 10.05 ph/ms; p = 10−4), in the PEX glaucoma group in comparison with control group (27.99 ± 15.45 vs 7.06 ± 2.95 ph/ms; p = 10−4), and in patients with unilateral PEX syndrome in comparison with contralateral-unaffected eyes (25.72 ± 14.88 vs 8.58 ± 3.45 ph/ms; p = 0.000). For patients with PEX syndrome, a high ACAF might be a predictor for the development of glaucoma. Further investigations are needed to clarify the role of laser flare photometry in predicting the risk of glaucoma in patients with PEX syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Küchle M, Vinores SA, Mahlow J, Green WR (1996) Blood-aqueous barrier in pseudoexfoliation syndrome: evaluation by immunohistochemical staining of endogenous albumin. Graefes Arch Clin Exp Ophthalmol 234:12–18

    Article  PubMed  Google Scholar 

  2. Brooks AM, Gillies WE (1983) Fluorescein angiography and fluorophotometry of the iris in pseudoexfoliation of the lens capsule. Br J Ophthalmol 67:249–254

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Tada H, Takahashi N, Kimura Y, Numaga T, Yoneya S (1988) Anterior segment fluorophotometry in pseudoexfoliation syndrome. Jpn J Clin Ophthalmol 42:698–699

    Google Scholar 

  4. Parodi MB, Liberali T, Iacono P, De Nicola M, Ballone E, Ravalico G (2008) The spectrum of iris angiography abnormalities in pseudoexfoliation syndrome. Eye 22:49–54

    Article  CAS  PubMed  Google Scholar 

  5. Küchle M, Nguyen NX, Horn F, Naumann GO (1992) Quantitative assessment of aqueous flare and aqueous ‘cells’ in pseudoexfoliation syndrome. Acta Ophthalmol (Copenh) 70:201–208

    Article  Google Scholar 

  6. Küchle M, Nguyen NX, Hannappel E, Beck W, Ho ST, Naumann GO (1994) Tyndallometry with the laser flare cell meter and biochemical protein determination in the aqueous humor of eyes with pseudoexfoliation syndrome. Ophthalmologe 91(5):578–584

    PubMed  Google Scholar 

  7. Küchle M, Nguyen NX, Hannappel E, Naumann GO (1995) The blood-aqueous barrier in eyes with pseudoexfoliation syndrome. Ophthalmic Res 27(Suppl1):136–142

    Article  PubMed  Google Scholar 

  8. Wang L, Yamasita R, Hommura S (1999) Corneal endothelial changes and aqueous flare intensity in pseudoexfoliation syndrome. Ophthalmologica 213:387–391

    Article  CAS  PubMed  Google Scholar 

  9. Ladas JG, Wheeler NC, Morhun PJ, Rimmer SO, Holland GN (2005) Laser flare-cell photometry: methodology and clinical applications. Surv Ophthalmol 50:27–47

    Article  PubMed  Google Scholar 

  10. Mori M, Araie M, Sakurai M, Oshika T (1992) Effects of pilocarpine and tropicamide on blood-aqueous barrier permeability in man. Invest Ophthalmol Vis Sci 33:416–423

    CAS  PubMed  Google Scholar 

  11. Cellini M, Caramazza R, Bonsanto D, Bernabini B, Campos EC (2004) Prostaglandin analogs and blood-aqueous barrier integrity: a flare cell meter study. Ophthalmologica 218:312–317

    Article  CAS  PubMed  Google Scholar 

  12. Nguyen NX, Martus P, Küchle M (1996) A clinical comparative study of tyndallometry using 2 laser flare meters. Klin Monatsblatter Augenheilkd 209:89–93

    Article  CAS  Google Scholar 

  13. Sein J, Galor A, Sheth A, Kruh J, Pasquale LR, Karp CL (2013) Exfoliation syndrome: new genetic and pathophysiologic insights. Curr Opin Ophthalmol 24:167–174

    Article  PubMed  Google Scholar 

  14. Dewundara S, Pasquale LR (2015) Exfoliation syndrome: a disease with an environmental component. Curr Opin Ophthalmol 26:78–81

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work has been supported by the Ministry of Higher Education and Research of Tunisia.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Fattouma Bourguiba University Hospital, University of Monastir, 5019, Monastir, Tunisia

    Rim Kahloun, Sonia Attia, Imen Ksiaa, Ilhem Kacem, Sonia Zaouali, Bechir Jelliti & Moncef Khairallah

  2. Department of Community and Preventive Medicine, Faculty of Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia

    Ines Bouanene

Authors
  1. Rim Kahloun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sonia Attia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Imen Ksiaa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ilhem Kacem
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ines Bouanene
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sonia Zaouali
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Bechir Jelliti
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Moncef Khairallah
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Moncef Khairallah.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kahloun, R., Attia, S., Ksiaa, I. et al. Anterior chamber aqueous flare, pseudoexfoliation syndrome, and glaucoma. Int Ophthalmol 36, 671–674 (2016). https://doi.org/10.1007/s10792-016-0169-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-016-0169-8

Keywords

Search

Navigation