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Primary orbital yolk sac tumor: report of a case and review of literature

International Ophthalmology volume 36, pages 435–444 (2016)Cite this article

Abstract

Germ cell tumor can affect extragonadal sites. Teratoma is a well-recognized extragonadal tumor in the orbit. Primary yolk sac tumor (YST) or endodermal sinus tumor of orbit is rare and only few cases have been reported in the literature. Its clinical presentation may mimic many common pediatric orbital conditions, and delay in diagnosis affects ocular morbidity and mortality. In the past orbital YST has been treated with multimodal therapy including surgery, systemic chemotherapy, and radiotherapy. Herein we describe a case of primary orbital YST and reviewed the literature for similar cases. The review aims to describe the clinical presentation, imaging features, histopathological characteristics, and management of orbital YST.

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Acknowledgment

Support provided by The Operation Eyesight Institute for Eye Cancer (SK) and Hyderabad Eye Research Foundation (SK), Hyderabad, India. The funders had no role in the preparation, review or approval of the manuscript.

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Affiliations

  1. The Operation Eyesight Universal Institute for Eye Cancer (SaK, SK), L V Prasad Eye Institute, Hyderabad, 500034, India

    Saurabh Kamal & Swathi Kaliki

  2. Ophthalmic Pathology Service (DKM), L V Prasad Eye Institute, Hyderabad, India

    Ani Sreedhar

  3. Little Flower Eye Hospital (AS), Angamaly, Kerala, India

    Dilip K. Mishra

Authors
  1. Saurabh Kamal
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  2. Swathi Kaliki
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  3. Ani Sreedhar
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  4. Dilip K. Mishra
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Correspondence to Swathi Kaliki.

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Kamal, S., Kaliki, S., Sreedhar, A. et al. Primary orbital yolk sac tumor: report of a case and review of literature. Int Ophthalmol 36, 435–444 (2016). https://doi.org/10.1007/s10792-015-0142-y

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  • DOI: https://doi.org/10.1007/s10792-015-0142-y

Keywords

  • Eye
  • Orbit
  • Tumor
  • Orbital yolk sac tumor
  • Yolk sac carcinoma
  • Germ cell tumor