Abstract
Choroidal metastases, the most common form of intraocular malignancies, are principally caused by primary tumors from breast, lung, and gastrointestinal tract. These lesions are mostly symptomatic and rarely detected incidentally in the extension study of a previously diagnosed tumor. Leiomyosarcoma is a neoplasm of mesenchymal cells with smooth muscle differentiation and represents the most prevalent soft-tissue sarcoma. Leiomyosarcoma is a notably rare tumor in ophthalmic region. We report a case of primary bone leiomyosarcoma metastatic to the choroid that was treated with chemotherapy and surgery. Although three cases of choroidal metastasis from leiomyosarcomas have been already reported, to our knowledge this is the first case of choroidal metastasis from primary bone leiomyosarcoma.
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References
Toro JR, Travis LB, Hj Wu, Zhu K, Fletcher CD, Devesa SS (2006) Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results programm, 1978–2001: an analysis of 26,758 cases. Int J Cancer 119:2922–2930
Templeton K (2005) Leiomyosarcoma of bone. Am J Orthop 34(55):249–251
Nelson CC, Hertzberg BS, Klintworth GK (1983) A histopathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Opthalmol 95:788–793
Cl Shields, Shields JA, Gross NE et al (1997) Survey of 520 eyes with uveal metastases. Ophthalmology 104:1265–1276
Giuliari GP, Sadaka A (2012) Uveal metastatic disease: current and new treatment options. Oncol Rep 27:603–607
Bloch RS, Gartner S (1971) The incidence of ocular metastatic carcinoma. Arch Opthalmol 85:673–675
Cajaiba MM, Chojniak MM, Cunha IW (2008) Unusual primary ocular neoplasm in a child: leiomyosarcoma of the ciliary body. Pediatr Dev Pathol 11(6):479–481
Ferry AP, Font RL (1974) Carcinoma metastatic to the eye and orbit. A clinicopathologic study of 227 cases. Arch Opthalmol 92:276–286
Folberg R, Cleasby G, Flanagan JA, Spencer WH, Zimmerman LE (1983) Orbital leiomyosarcoma after radiation therapy for bilateral retinoblastoma. Arch Ophthalmol 101(10):1562–1565
Anderson MF, Coupland SE, Bissett D, Atta H, Damato BE (2011) Choroidal metastasis from primary pulmonary leiomyosarcoma. Clin Exp Ophthalmol 39:705–707
Feinstein E, Kaliki S, Shields CL, Ehya H, Shields JA (2014) Choroidal metastasis from leiomyosarcoma in two cases. Oman J Ophthalmol 7(1):19–21
Shields CL, Shields JA, De Potter P, Quaranta M, Freire J, Brady LW et al (1997) Plaque radiotherapy for the management of uveal metastasis. Arch Ophthalmol 115:203–209
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Cristina, N.G., Francisco, E.D., Vanesa, R.G. et al. Choroidal metastasis from primary bone leiomyosarcoma. Int Ophthalmol 35, 721–725 (2015). https://doi.org/10.1007/s10792-015-0096-0
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DOI: https://doi.org/10.1007/s10792-015-0096-0