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Comparison of the current and a new RTVue OCT software version for detection of ganglion cell complex changes due to cataract surgery

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Abstract

The purpose was to compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue OCT) for ganglion cell complex (GCC) and retinal nerve fibre layer thickness (RNFLT) changes after phacoemulsification in healthy cataract eyes, and to investigate whether version 6.12, in which image segmentation is improved, provides benefits over version 6.3 for RNFLT and GCC imaging via mild cataract. One eye of 22 consecutive healthy cataract patients were imaged before and 1 month after uncomplicated cataract surgery using RTVue-100 OCT software version 6.3. The images were analysed with both software versions. Signal strength index increased significantly after surgery for both RNFLT and the GCC measurements (p ≤ 0.0015). No difference was seen for any RNFLT parameter between the software versions and time points (p ≥ 0.0140). The GCC values did not differ between the versions either before or after surgery (p ≥ 0.4471), but all increased significantly after surgery with software version 6.12 (p < 0.0001). Neither focal loss volume (FLV) nor global loss volume (GLV) differed between the software versions before and after surgery, respectively, but GLV decreased (improved) significantly after surgery (p = 0.010 and <0.001 for versions 6.3 and 6.12, respectively). Cataract surgery induced similar changes with both software versions, but version 6.12 identified the increase of GCC thickness and the decrease of GLV better than the current version. Although no significant difference between software versions was seen before surgery, our results suggest that version 6.12 may be more precise in measuring GCC parameters than the currently available version.

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References

  1. Sung M-S, Yoon J-H, Park S-W (2013) Diagnostic validity of macular ganglion cell-inner plexiform layer thickness deviation map algorithm using cirrus HD-OCT in preperimetric and early glaucoma. J Glaucoma. doi:10.1097/IJG.0000000000000028

    PubMed  Google Scholar 

  2. Nakatani Y, Higashide T, Ohkubo S et al (2011) Evaluation of macular thickness and peripapillary retinal nerve fiber layer thickness for detection of early glaucoma using spectral domain optical coherence tomography. J Glaucoma 20:252–259

    Article  PubMed  Google Scholar 

  3. Garas A, Vargha P, Holló G (2011) Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma. Eye 25:57–65

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Shin H-Y, Park H-YL, Jung Y et al (2014) Glaucoma diagnostic accuracy of optical coherence tomography parameters in early glaucoma with different types of optic disc damage. Ophthalmology. doi:10.1016/j.ophtha.2014.04.030

    PubMed Central  Google Scholar 

  5. Kim NR, Lee EK, Seong GJ et al (2011) Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia. Br J Ophthalmol 95:1115–1121

    Article  PubMed  Google Scholar 

  6. Mori S, Hangai M, Sakamoto A, Yoshimura N (2010) Spectral-domain optical coherence tomography measurement of macular volume for diagnosing glaucoma. J Glaucoma 19:528–534

    Article  PubMed  Google Scholar 

  7. Nouri-Mahdavi K, Nowroozizadeh S, Nassiri N et al (2013) Macular ganglion cell/inner plexiform layer measurements by spectral domain optical coherence tomography for detection of early glaucoma and comparison to retinal nerve fiber layer measurements. Am J Ophthalmol 156:1297–1307

    Article  PubMed  Google Scholar 

  8. Choi YJ, Jeoung JW, Park KH, Kim DM (2013) Glaucoma detection ability of ganglion cell-inner plexiform layer thickness by spectral-domain optical coherence tomography in high myopia. Invest Ophthalmol Vis Sci 54:2296–2304

    Article  PubMed  Google Scholar 

  9. Tan O, Chopra V, Lu AT et al (2009) Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology 116:2305–2314

    Article  PubMed Central  PubMed  Google Scholar 

  10. Seong M, Sung KR, Choi EH et al (2010) Macular and peripapillary retinal nerve fiber layer measurements by spectral domain optical coherence tomography in normal-tension glaucoma. Invest Ophthalmol Vis Sci 51:1446–1452

    Article  PubMed  Google Scholar 

  11. Naghizadeh F, Garas A, Vargha P, Holló G (2014) Detection of early glaucomatous progression with different parameters of the RTVue optical coherence tomograph. J Glaucoma 23:195–198

    Article  PubMed  Google Scholar 

  12. Sung KR, Sun JH, Na JH et al (2012) Progression detection capability of macular thickness in advanced glaucomatous eyes. Ophthalmology 119:308–313

    Article  PubMed  Google Scholar 

  13. Bambo PM, Garcia-Martin E, Otin S et al (2014) Influence of cataract surgery on repeatability and measurements of spectral domain optical coherence tomography. Br J Ophthalmol 98:52–58

    Article  PubMed  Google Scholar 

  14. Kim NR, Lee H, Lee ES et al (2012) Influence of cataract on time domain and spectral domain optical coherence tomography retinal nerve fiber layer measurements. J Glaucoma 21:116–122

    PubMed  Google Scholar 

  15. Garcia-Martin E, Fernandez J, Gil-Arribas L et al (2013) Effect of cataract surgery on optical coherence tomography measurements and repeatability in patients with non-insulin-dependent diabetes mellitus. Invest Ophthalmol Vis Sci 54:5303–5312

    Article  PubMed  Google Scholar 

  16. Mwanza JC, Bhorade AM, Sekhon N et al (2011) Effect of cataract and its removal on signal strength and peripapillary retinal nerve fiber layer optical coherence tomography measurements. J Glaucoma 20:37–43

    Article  PubMed  Google Scholar 

  17. Sánchez-Cano A, Pablo LE, Larossa JM et al (2010) The effect of phacoemulsification cataract surgery on polarimetry and tomography measurements for glaucoma diagnosis. J Glaucoma 19:468–474

    Article  PubMed  Google Scholar 

  18. Georgopoulos GT, Papaconstantinou D, Niskopoulo M et al (2008) Foveal thickness after phacoemulsification as measured by optical coherence tomography. Clin Ophthalmol 2:817–820

    PubMed Central  PubMed  Google Scholar 

  19. Stock G, Ahlers C, Dunavoelgyi R et al (2011) Evaluation of anterior-segment inflammation and retinal thickness change following cataract surgery. Acta Ophthalmol 89:369–375

    Article  PubMed  Google Scholar 

  20. Biro Z, Balla Z, Kovacs B (2008) Change of foveal and perifoveal thickness measured by OCT after phacoemulsification and IOL implantation. Eye 22:8–12

    Article  CAS  PubMed  Google Scholar 

  21. Ecsedi M, Miháltz K, Kovács I et al (2011) Effect of femtosecond laser cataract surgery on the macula. J Refract Surg 27:717–722

    Article  Google Scholar 

  22. Garas A, Vargha P, Holló G (2010) Reproducibility of retinal nerve fiber layer and macular thickness measurement with the RTVue-100 optical coherence tomography. Ophthalmology 117:738–746

    Article  PubMed  Google Scholar 

  23. Optovue Inc. (2011) User’s manual for users only outside the United States to RTVue 100 OCT version 6.3, 09/2011

  24. Holló G, Naghizadeh F (2015) Influence of a new software version of the RTVue-100 optical coherence tomograph on ganglion cell complex segmentation in various forms of age-related macular degeneration. J Glaucoma 24:245–250

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Acknowledgments

The authors thank Péter Vargha for the statistical analysis, and Miklós Resch for patient recruitment to the study.

Conflict of interest

Gábor Holló is an unpaid consultant of Optovue, Inc. and Carl Zeiss Meditec, Inc. The other authors declare no conflict of interests.

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Authors and Affiliations

  1. Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary

    Gábor Holló, Farzaneh Naghizadeh, Sofia Hsu, Tamás Filkorn & Mária Bausz

  2. College of Medicine, University of Central Florida, Orlando, FL, USA

    Sofia Hsu

Authors
  1. Gábor Holló
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  2. Farzaneh Naghizadeh
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  3. Sofia Hsu
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  4. Tamás Filkorn
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  5. Mária Bausz
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Correspondence to Gábor Holló.

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Holló, G., Naghizadeh, F., Hsu, S. et al. Comparison of the current and a new RTVue OCT software version for detection of ganglion cell complex changes due to cataract surgery. Int Ophthalmol 35, 861–867 (2015). https://doi.org/10.1007/s10792-015-0064-8

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  • DOI: https://doi.org/10.1007/s10792-015-0064-8

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