Abstract
To evaluate the pattern of retinal nerve fibre layer defects (RNFLD) with regard to involvement of papillomacular bundle (PMB) in glaucoma. This observational study included patients attending glaucoma imaging services at our centre from 2011 to 2012. All images were exported to Image J software for analysis and rescaled to a unified scale for measurement of degree of RNFLD defined by its angular width, pattern of involvement with regard to involvement or sparing of PMB in particular and horizontal and vertical distance of central vessel trunk (CVT) from the disc margin. Association of clinical data with pattern of defects with regard to PMB involvement was analysed. Sixty-two fundus photographs with discernible nerve fibre layer defects on red free images were selected, including 48 normal tension glaucoma, two primary angle closure glaucoma (PACG) and 12 primary open angle glaucoma (POAG) eyes. Discernible PMB involvement was seen in 35 eyes which included 31 defects in inferior quadrant while CVT exit was placed in the quadrant opposite to the quadrant of RNFLD in that eye. The mean vertical distance from the nearest disc margin was greater in eyes without PMB involvement, 0.4 ± 0.02 mm, than eyes with PMB defects, 0.3 ± 0.01 mm, p < 0.001. On multivariate logistic regression, PMB involvement was significantly associated with decreased linear horizontal of the CVT from the disc margin, p = 0.003. Selective involvement of superior and inferior PMB suggests different retinotopic representation within the optic disc. Exit of the CVT towards the disc margin may be a predisposing factor for RNFLD and involvement of the PMB.
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References
Radius RL, Anderson DR (1979) The course of axons through the retina and optic nerve head. Arch Ophthalmol 97:1154–1158
Ogden TE (1984) Nerve fiber layer of the primate retina: morphometric analysis. Invest Ophthalmol Vis Sci 25:19–29
Kimura Y, Hangai M, Morooka S, Takayama K, Nakano N, Nukada M, Ikeda HO, Akagi T, Yoshimura N (2012) Retinal nerve fiber layer defects in highly myopic eyes with early glaucoma. Invest Ophthalmol Vis Sci 53:6472–6478
Rao A, Mukherjee S (2014) Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. PLoS One. doi:10.1371/journal.pone.0090554
Jonas JB, Mueller-Bergh JA, Schloetzer-Schrehardt UM, Naumann GOH (1990) Histomorphometry of the human optic nerve. Invest Ophthalmol Vis Sci 31:736–744
Quigley HA, Addicks EM (1981) Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol 99:137–143
Jonas JB, Schmidt AM, Mueller-Bergh JA, Schloetzer-Schrehardt UM, Naumann GOH (1992) Human optic nerve fiber count and optic disc size. Invest Ophthalmol Vis Sci 33:2012–2018
FitzGibbon T, Taylor SF (1996) Retinotopy of the human retinal nerve fibre layer and optic nerve head. J Comp Neurol 375:238–251
Pavlidis M, Stupp T, Hummeke M, Thanos S (2006) Morphometric examination of human and monkey retinal ganglion cells within the papillomacular area. Retina 26:445–453
Caprioli J, Sears M, Miller JM (1987) Patterns of early visual field loss in open-angle glaucoma. Am J Ophthalmol 103:512–517
Araie M, Sekine M, Suzuki Y, Koseki N (1994) Factors contributing to the progression of visual field damage in eyes with normal-tension glaucoma. Ophthalmology 101:1440–1444
Lieberman MF, Maumenee EA, Green RW (1976) Histologic studies of the vasculature of the anterior optic nerve. Am J Ophthalmol 82:405–423
Lee SS, Schwartz B (1992) Role of the temporal cilioretinal artery in retaining central visual field in open-angle glaucoma. Ophthalmology 99:696–699
Huang H, Jonas JB, Dai Y, Hong J, Wang M, Chen J, Wu J, Sun X (2013) Position of the central retinal vessel trunk and pattern of remaining visual field in advanced glaucoma. Br J Ophthalmol 97:96–100
Jonas JB, Fernández MC (1994) Shape of the neuroretinal rim and position of the central retinal vessels in glaucoma. Br J Ophthalmol 78:99–102
Park SC, De Moraes CG, Teng CC, Tello C, Liebmann JM, Ritch R (2011) Initial parafoveal versus peripheral scotomas in glaucoma: risk factors and visual field characteristics. Ophthalmology 118:1782–1789
Pavlidis M, Stupp T, Naskar R, Cengiz C, Thanos S (2003) Retinal ganglion cells resistant to advanced glaucoma: a postmortem study of human retinas with the carbocyanine dye DiI. Invest Ophthalmol Vis Sci 44:5196–5205
Mitchell P, Hourihan F, Sandbach J, Wang JJ (1999) The relationship between glaucoma and myopia: the blue mountains eye study. Ophthalmology 106:2010–2015
Yang H, Downs JC, Girkin C, Sakata L, Bellezza A, Thompson H, Burgoyne CF (2007) 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thickness. Invest Ophthalmol Vis Sci 48:4597–4607
Kim TW, Kim M, Weinreb RN, Woo SJ, Park KH, Hwang JM (2012) Optic disc change with incipient myopia of childhood. Ophthalmology 119:21–26
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Rao, A., Mukherjee, S. & Padhy, D. Optic nerve head characteristics in eyes with papillomacular bundle defects in glaucoma. Int Ophthalmol 35, 819–826 (2015). https://doi.org/10.1007/s10792-015-0053-y
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DOI: https://doi.org/10.1007/s10792-015-0053-y