Skip to main content

Advertisement

SpringerLink
Log in

Specific IgG for cat allergens in patients with allergic conjunctivitis

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Immunoglobulin G (IgG) antibodies are involved in type II and type III hypersensitivity. We evaluated the relation between perennial allergic conjunctivitis and serum levels of specific IgG for cat allergens. A prospective study was conducted in patients with seasonal allergic conjunctivitis (seasonal group, n = 10), patients with perennial allergic conjunctivitis (perennial group, n = 10), and healthy control subjects (control group, n = 10). Serum levels of specific IgE and IgG for cat allergens and total tear IgE were measured, and a skin prick test was also performed. In addition, a severity score associated with allergic conjunctivitis was calculated (0–30). The positive rates and scores of for total tear IgE, serum cat-specific IgE, and serum cat-specific IgG were all higher in the seasonal and perennial groups than in the control group (all p < 0.05). Serum cat-specific IgG levels were higher in the perennial group than in the seasonal group (p = 0.0156), but there was no significant difference in the grade of cat-specific IgE between the two groups (p = 0.3008). On multivariate analysis, the mean wheal diameter for cat allergen was associated with the serum level of cat-specific IgG (not IgE) in all patients [odds ratio (OR) = 31.979, p < 0.0001]. Multivariate analysis revealed that the total objective score was strongly associated with serum cat-specific IgG (OR = 23.015, p < 0.0001). These findings suggest that specific IgG antibodies may be involved in perennial allergic symptoms caused by indoor allergens such as cat allergens.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Gould HJ, Sutton BJ, Beavil AJ, Beavil RL, McCloskey N, Coker HA, Fear D, Smurthwaite L (2003) The biology of IGE and the basis of allergic disease. Annu Rev Immunol 21:579–628

    Article  CAS  PubMed  Google Scholar 

  2. Mimura T, Amano S, Funatsu H, Yamagami S, Araie M, Kaji Y, Arimoto A, Ishida Y, Usui T, Okamoto S (2004) Correlations between allergen-specific IgE serum levels in patients with allergic conjunctivitis in spring. Ocul Immunol Inflamm 12(1):45–51

    Article  PubMed  Google Scholar 

  3. Mimura T, Yamagami S, Amano S, Funatsu H, Arimoto A, Usui T, Ono K, Araie M, Okamoto S (2005) Allergens in Japanese patients with allergic conjunctivitis in autumn. Eye (Lond) 19(9):995–999

    Article  CAS  Google Scholar 

  4. Custovic A, Soderstrom L, Ahlstedt S, Sly PD, Simpson A, Holt PG (2011) Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood. J Allergy Clin Immunol 127(6):1480–1485

    Article  CAS  PubMed  Google Scholar 

  5. Zimmer A, Bexley J, Halliwell RE, Mueller RS (2011) Food allergen-specific serum IgG and IgE before and after elimination diets in allergic dogs. Vet Immunol Immunopathol 144(3–4):442–447

    Article  CAS  PubMed  Google Scholar 

  6. Bethlehem S, Bexley J, Mueller RS (2012) Patch testing and allergen-specific serum IgE and IgG antibodies in the diagnosis of canine adverse food reactions. Vet Immunol Immunopathol 145(3–4):582–589

    Article  CAS  PubMed  Google Scholar 

  7. Sverremark-Ekström E, Hultgren EH, Borres MP, Nilsson C (2012) Peanut sensitization during the first 5 yr of life is associated with elevated levels of peanut-specific IgG. Pediatr Allergy Immunol 23(3):224–229

    Article  PubMed  Google Scholar 

  8. Zuo XL, Li YQ, Li WJ, Guo YT, Lu XF, Li JM, Desmond PV (2007) Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia. Clin Exp Allergy 37(6):823–830

    Article  CAS  PubMed  Google Scholar 

  9. Volpi N, Maccari F (2009) Serum IgG responses to food antigens in the italian population evaluated by highly sensitive and specific ELISA test. J Immunoass Immunochem 30(1):51–69

    Article  CAS  Google Scholar 

  10. Fernández C, Cárdenas R, Martín D, Garcimartín M, Romero S, de la Cámara AG, Vives R (2007) Analysis of skin testing and serum-specific immunoglobulin E to predict airway reactivity to cat allergens. Clin Exp Allergy 37(3):391–399

    Article  PubMed  Google Scholar 

  11. Ben Ezra D (1994) Guidelines on the diagnosis and treatment of conjunctivitis. Ocul Immunol Inflamm 2(Suppl):17–26

    Google Scholar 

  12. Leonardi A, Bogacka E, Fauquert JL, Kowalski ML, Groblewska A, Jedrzejczak-Czechowicz M, Doan S, Marmouz F, Demoly P, Delgado L (2012) Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface. Allergy 67:1327–1337

    Article  CAS  PubMed  Google Scholar 

  13. Japanese Ocular Allergology Study Group (2006) Guidelines for the clinical management of allergic conjunctival diseases. The Japanese Ophthalmological Society. Nippon Ganka Gakkai Zasshi 110:103–140

    Google Scholar 

  14. Uchio E, Kimura R, Migita H, Kozawa M, Kadonosono K (2008) Demographic aspects of allergic ocular diseases and evaluation of new criteria for clinical assessment of ocular allergy. Graefes Arch Clin Exp Ophthalmol 246:291–296

    Article  PubMed  Google Scholar 

  15. Ohashi Y, Ebihara N, Fujishima H, Fukushima A, Kumagai N, Nakagawa Y, Namba K, Okamoto S, Shoji J, Takamura E, Hayashi K (2010) A randomized, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis. J Ocul Pharmacol Ther 26:165–174

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Sirbikaite L, Ehlers N (2007) The use of lacrytest in ocular allergy. Acta Ophthalmol Scand 85:117

    Article  PubMed  Google Scholar 

  17. Monzón S, Arrondo E, Bartra J, Torres F, Basagaña M, Del Mar San Miguel M, Alonso R, Cisteró-Bahima A (2009) Conjunctivitis and total IgE in lacrimal fluid: lacrytest screening. J Allergy 2009:1–6

    Article  Google Scholar 

  18. Inada N, Shoji J, Kato H, Kiely S, Mulyanto N, Sawa M (2009) Clinical evaluation of total IgE in tears of patients with allergic conjunctivitis disease using a novel application of the immunochromatography method. Allergol Int 58:585–589

    Article  CAS  PubMed  Google Scholar 

  19. Mimura FT, Usui T, Mori M, Funatsu H, Noma H, Aixinjueluo W, Yamamoto H, Amano S (2010) Rapid immunochromatography of total tear immunoglobulin E in allergic conjunctivitis with Allerwatch. J Investig Allergol Clin Immunol 20(7):627–628

    CAS  PubMed  Google Scholar 

  20. Mimura T, Usui T, Mori M, Aixinjueluo W, Funatsu H, Noma H, Amano S (2010) Immunochromatographic assay for measurement of total IgE in tears, nasal mucus, and saliva of patients with allergic rhinoconjunctivitis. J Asthma 47(10):1153–1160

    Article  CAS  PubMed  Google Scholar 

  21. Mimura T, Usui T, Mori M, Funatsu H, Noma H, Yamamoto H, Aixinjueluo W, Amano S (2011) Relationship between total tear and serum IgE in allergic conjunctivitis. Int Arch Allergy Immunol 154(4):349–352

    Article  CAS  PubMed  Google Scholar 

  22. Mimura T, Usui T, Mori M, Funatsu H, Noma H, Yamamoto H, Aixinjueluo W, Amano S (2011) Relation between total tear IgE and specific serum IgE in seasonal allergic conjunctivitis. Cornea 30(7):790–795

    Article  PubMed  Google Scholar 

  23. Mimura T, Usui T, Yamagami S, Miyai T, Amano S (2012) Relation between total tear IgE and severity of acute seasonal allergic conjunctivitis. Curr Eye Res 37(10):864–870

    Article  CAS  PubMed  Google Scholar 

  24. Mimura T (2013) Bilateral eyelid erythema associated with false eyelash glue. Cutan Ocul Toxicol 32(1):89–90

    Article  PubMed  Google Scholar 

  25. Mimura T, Usui T, Yamagami S, Miyai T, Amano S (2013) Relationship between total tear IgE and specific serum IgE in autumnal allergic conjunctivitis. Cornea 32(1):14–19

    Article  PubMed  Google Scholar 

  26. Mimura T, Yamagami S, Kamei Y, Goto M, Kondo A, Matsubara M (in press) Measurement of specific tear IgE with ImmunoCAP Rapid. J Investig Allergol Clin Immunol

  27. Suen RM, Gordon S (2003) The clinical relevance of IgG food allergy testing through ELISA (enzyme-linked immunosorbent assay). US BioTek Laboratories©, Seattle, WA, pp 1–8

  28. Hodsdon W, Zwickey H (2010) NMJ original research: reproducibility and reliability of two food allergy testing methods. Nat Med J 2(3):8–13

    Google Scholar 

  29. Warm K, Lindberg A, Lundbäck B, Rönmark E (2013) Increase in sensitization to common airborne allergens among adults—two population-based studies 15 years apart. Allergy Asthma Clin Immunol 9(1):20

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Aburuz S, Bulatova N, Tawalbeh M (2011) Skin prick test reactivity to aeroallergens in Jordanian allergic rhinitis patients. East Mediterr Health J 17(7):604–610

    CAS  PubMed  Google Scholar 

  31. Yuen AP, Cheung S, Tang KC, Ho WK, Wong BY, Cheung AC, Ho AC (2007) The skin prick test results of 977 patients suffering from chronic rhinitis in Hong Kong. Hong Kong Med J 13(2):131–136

    PubMed  Google Scholar 

  32. Almqvist C, Egmar AC, Hedlin G, Lundqvist M, Nordvall SL, Pershagen G, Svartngren M, van Hage-Hamsten M, Wickman M (2003) Direct and indirect exposure to pets-risk of sensitization and asthma at 4 years in a birth cohort. Clin Exp Allergy 33:1190–1197

    Article  CAS  PubMed  Google Scholar 

  33. Svanes C, Heinrich J, Jarvis D, Chinn S, Omenaas E, Gulsvik A, Kunzli N, Burney P (2003) Pet-keeping in childhood and adult asthma and hay fever: European Community Respiratory Health Survey. J Allergy Clin Immunol 112:289–300

    Article  PubMed  Google Scholar 

  34. Liccardi G, Martín S, Lombardero M, D’Amato M, Barber D, D’Amato G, Cazzola M (2005) Cutaneous and serological responses to cat allergen in adults exposed or not to cats. Respir Med 99(5):535–544

    Article  PubMed  Google Scholar 

  35. Ritz BR, Hoelscher B, Frye C, Meyer I, Heinrich J (2002) Allergic sensitization owing to ‘second-hand’ cat exposure in schools. Allergy 57(4):357–361

    Article  CAS  PubMed  Google Scholar 

  36. Heissenhuber A, Heinrich J, Fahlbush B, Borte M, Wickmann HE, Bolte G (2003) Health impacts of second-hand exposure to cat allergen Fel d 1 in infants. Allergy 58:154–157

    Article  CAS  PubMed  Google Scholar 

  37. Bollinger ME, Eggleston PA, Flanagan E, Wood RA (1996) Cat antigen in homes with or without cats may induce allergic symptoms. J Allergy Clin Immunol 97:907–914

    Article  CAS  PubMed  Google Scholar 

  38. Enberg RN, Shamie SM, McCullough J, Ownby DR (1993) Ubiquitous presence of cat allergen in cat-free buildings: probable dispersal from human clothing. Ann Allergy 70:471–474

    CAS  PubMed  Google Scholar 

  39. Custovic A, Taggart SC, Woodcock A (1994) House dust mite and cat allergen in different indoor environments. Clin Exp Allergy 24:1164–1168

    Article  CAS  PubMed  Google Scholar 

  40. Partti-Pellinen K, Marttila O, Makinen-Kiljunen S, Haatela T (2000) Occurrence of dog, cat and mite allergens in public transport vehicles. Allergy 55:65–68

    Article  CAS  PubMed  Google Scholar 

  41. Patchett K, Lewis S, Crane J, Fitzharris P (1997) Cat allergen (Fel d 1) levels on school children’s clothing and in primary school classrooms in Wellington, New Zealand. J Allergy Clin Immunol 100:755–759

    Article  CAS  PubMed  Google Scholar 

  42. D’Amato G, Liccardi G, Russo M, Barber D, D’Amato M, Carreira J (1997) Clothing is a carrier of cat allergens. J Allergy Clin Immunol 99:577–578

    Article  PubMed  Google Scholar 

  43. Almqvist C, Larsson PH, Egmar AC, Hedrén M, Malmberg P, Wickman M (1999) School as a risk environment for children allergic to cats and a site for transfer of cat allergen to homes. J Allergy Clin Immunol 103:1012–1017

    Article  CAS  PubMed  Google Scholar 

  44. Liccardi G, D’Amato G, Russo M, Canonica GW, D’Amato L, De Martino M, Passalacqua G (2003) Focus on cat allergen (Fel d 1): immunological and aerodynamic characteristics, modality of airway sensitization and avoidance strategies. Int Arch Allergy Immunol 132:1–12

    Article  CAS  PubMed  Google Scholar 

  45. Mimura T, Usui T, Mori M, Funatsu H, Noma H, Amano S (2011) Specific tear IgE in patients with moderate-to-severe autumnal allergic conjunctivitis. Int Arch Allergy Immunol 156:381–386

    Article  CAS  PubMed  Google Scholar 

  46. Mimura T, Yamagami S, Kamei Y, Goto M, Matsubara M (2013) Specific IgE in tear fluid and features of allergic conjunctivitis. Curr Eye Res 38:917–925

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Health Labour Sciences Research Grant from The Ministry of Health Labour and Welfare of Japan.

Conflict of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and for writing this paper.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, 2-1-10 Nishiogu, Arakawa-ku, Tokyo, 116-8567, Japan

    Anri Miyama, Tatsuya Mimura, Mari Goto, Yuko Kamei, Aki Kondo, Yusuke Saito, Hiroko Okuma & Masao Matsubara

  2. Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan

    Hidetaka Noma

Authors
  1. Anri Miyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tatsuya Mimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hidetaka Noma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mari Goto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yuko Kamei
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Aki Kondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yusuke Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hiroko Okuma
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Masao Matsubara
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tatsuya Mimura.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Miyama, A., Mimura, T., Noma, H. et al. Specific IgG for cat allergens in patients with allergic conjunctivitis. Int Ophthalmol 35, 575–586 (2015). https://doi.org/10.1007/s10792-014-9987-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-014-9987-8

Keywords

Search

Navigation