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Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice

International Ophthalmology volume 35, pages 115–120 (2015)Cite this article

Abstract

The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model. Twenty-eight male BALB/C mice were made diabetic by the intraperitoneal administration of streptozotocin (200 mg/kg). Three weeks after induction of diabetes, mice were divided randomly into 4 groups in which each group contained 7 mice; fisetin-treated group (group 1), α-lipoic acid-treated group (group 2), fisetin placebo group (group 3), α-lipoic acid placebo group (group 4). Fisetin and α-lipoic acid were administered intraperitoneally weekly for 5 weeks. Cataract development was assessed at the end of 8 weeks by slit lamp examination, and cataract formation was graded using a scale. All groups developed at least grade 1 cataract formation. In the fisetin-treated group, the cataract stages were significantly lower than in the placebo group (p = 0.02). In the α-lipoic acid-treated group, the cataract stages were lower than in the placebo group but it did not reach to a significant value. Both fisetin and α-lipoic acid had a protective effect on cataract development in a streptozotocin-induced experimental cataract model. The protective effect of fisetin appears as though more effective than α-lipoic acid.

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The authors have no conflict of interest.

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Authors and Affiliations

  1. Department of Ophthalmology, Samsun Training and Research Hospital, Samsun, Turkey

    Emrah Kan

  2. Department of Endocrinology and Metabolism, Samsun Training and Research Hospital, Samsun, Turkey

    Elif Kiliçkan

  3. Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey

    Ahmet Ayar

  4. Department of Endocrinology and Metabolism, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey

    Ramis Çolak

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  1. Emrah Kan
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  2. Elif Kiliçkan
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  3. Ahmet Ayar
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  4. Ramis Çolak
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Correspondence to Emrah Kan.

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Kan, E., Kiliçkan, E., Ayar, A. et al. Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. Int Ophthalmol 35, 115–120 (2015). https://doi.org/10.1007/s10792-014-0029-3

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  • DOI: https://doi.org/10.1007/s10792-014-0029-3

Keywords

  • α-Lipoic acid
  • Antioxidants
  • Diabetic cataract
  • Experimental cataract
  • Fisetin