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The study of etiological and demographic characteristics of pterygium recurrence: a consecutive case series study from Pakistan

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Abstract

To determine the agents of recurrence, the demographic features, and the management and outcomes of pterygium cases treated at Aga Khan University Hospital (AKUH), Karachi. This hospital-based descriptive study included 147 patients with pterygium (147 eyes) from both sexes, who presented at the Ophthalmology Department at AKUH between January 1, 2002 and December 31, 2010. Data regarding their demographic profile and other factors were collected in a well-structured proforma. Data were analyzed using frequencies, proportions, group means, standard deviations, and Pearson’s chi squared test. The male to female ratio in our study was 2:1, with factors such as younger age (<50 years) at presentation (P = 0.04, Pearson’s chi squared test) and the presence of secondary pterygium (P = 0.050) correlated significantly with the recurrence of pterygium. There was a definite trend of decreased recurrence seen with lower grade of pterygium (P = 0.06). The recurrence rate in our study was 8.8 %. These results suggest that a younger age coupled with a higher grade of pterygium as well as a history of multiple recurrences leads to increased susceptibility of recurrence after surgical excision. Early diagnosis and appropriate management will lead to a better prognosis.

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References

  1. Ang LP, Chua JL, Tan DT (2007) Current concepts and techniques in pterygium treatment. Curr Opin Ophthalmol 18(4):308–313

    Article  PubMed  Google Scholar 

  2. Gupta VP, Saxena T (2003) Comparison of single-drop mitomycin C regime with other mitomycin C regimes in pterygium surgery. Indian J Ophthalmol 51:59–65

    PubMed  Google Scholar 

  3. Mahar PS, Manzar N, Ahmad K (2011) The effect of intra-operative use of topical mitomycin-C on intra-ocular pressure in patients with pterygium excision. Asian J Ophthalmol 12:144–148

    Google Scholar 

  4. D’Ombrain A (1948) The surgical treatment of pterygium. Br J Ophthalmol 32:65–71

    Article  PubMed  Google Scholar 

  5. Hirst LW (2003) The treatment of pterygium. Surv Ophthalmol 48(2):145–180

    Article  PubMed  Google Scholar 

  6. Mutlu FM, Sobaci G, Tatar T, Yildirim E (1999) A comparative study of recurrent pterygium surgery: limbal conjunctival autograft transplantation versus mitomycin C with conjunctival flap. Ophthalmology 106:817–821

    Article  CAS  PubMed  Google Scholar 

  7. Sharma A, Gupta A, Ram J, Gupta A (2000) Low-dose intraoperative mitomycin-C versus conjunctival autograft in primary pterygium surgery: long term follow-up. Ophthalmic Surg Lasers 31:301–307

    CAS  PubMed  Google Scholar 

  8. Kunitomo N, Mori S (1963) Studies on the pterygium. Part 4. A treatment of the pterygium by mitomycin C instillation. Acta Soc Ophthalmol Jpn 67:601–607

    Google Scholar 

  9. Singh G, Wilson MR, Foster CS (1988) Mitomycin eye drops as treatment for pterygium. Ophthalmology 95:813–821

    Article  CAS  PubMed  Google Scholar 

  10. Mahar PS, Manzar N, Hassan M, Ahmad T (2010) The effect of sub-conjunctival mitomycin-C on intra-ocular pressure in various types of glaucoma. Asian J Ophthalmol 12:2–6

    Google Scholar 

  11. Oguz H, Basar E, Gurler B (1999) Intraoperative application versus postoperative mitomycin C eye drops in pterygium surgery. Acta Ophthalmol Scand 77(2):147–150

    Article  CAS  PubMed  Google Scholar 

  12. Hata T, Hoshi T, Kanamori K, Matsumae A, Shima T, Sugawara R (1956) Mitomycin, a new antibiotic from Streptomyces. I. J Antibiot (Tokyo) 9(4):141–146

    CAS  Google Scholar 

  13. Qing-feng L, Liang X, Xiu-ying J, Qi-sheng Y, Xiao-hui Y, Tong-tong C (2010) Epidemiology of pterygium in aged rural population of Beijing, China. Chin Med J 123(13):1699–1701

    Google Scholar 

  14. Bradley JC, Yang W, Bradley RH, Reid TW, Schwab IR (2010) The science of pterygia. Br J Ophthalmol 94(7):815–820

    Article  CAS  PubMed  Google Scholar 

  15. Gazzard G, Saw SM, Farook M, Koh D, Widjaja D, Chia SE et al (2002) Pterygium in Indonesia: prevalence, severity and risk factors. Br J Ophthalmol 86(12):1341–1346

    Article  CAS  PubMed  Google Scholar 

  16. Mahar PS, Nwokora GE (1993) Role of mitomycin-C in pterygium surgery. Br J Ophthalmol 77:433–435

    Article  CAS  PubMed  Google Scholar 

  17. Hayasaka S, Noda S, Yamamoto Y et al (1988) Postoperative instillation of low dose mitomycin-C in the treatment of primary pterygium. Am J Ophthalmol 106:715–718

    Article  CAS  PubMed  Google Scholar 

  18. Rachmiel R, Leibe H, Levartovsky S (1995) Results of treatment with topical mitomycin C 0.02 % following excision of primary pterygium. Br J Ophthalmol 79:233–239

    Article  CAS  PubMed  Google Scholar 

  19. Panda A, Das GK, Tuli SW, Kumar A (1998) Randomized trial of intra-operative mitomycin C in surgery for pterygium. Am J Ophthalmol 125:59–63

    Article  CAS  PubMed  Google Scholar 

  20. Lam DS, Wong AK, Fan DS, Chew S, Kwok PS, Tso MO (1998) Intraoperative mitomycin C to prevent recurrence of pterygium after excision: a 30-month follow-up study. Ophthalmology 105(5):901–904

    Article  CAS  PubMed  Google Scholar 

  21. Rahman A, Yahya K, Shariful Hasan K (2008) Recurrence rate of pterygium following surgical excision with intraoperative versus postoperative mitomycin-C. J Coll Physicians Surg Pak 18(8):489–492

    PubMed  Google Scholar 

  22. Cheng HC, Tseng SH, Kao PL, Chen FK (2001) Low-dose intraoperative mitomycin C as chemoadjuvant for pterygium surgery. Cornea 20(1):24–29

    Article  CAS  PubMed  Google Scholar 

  23. Narsani AK, Jatoi SM, Gul S, Dabir SA (2008) Treatment of primary pterygium with conjunctival autograft and mitomycin C. A comparative study. J Liaquat Uni Med Health Sci 7(3):184–187

    Google Scholar 

  24. Frucht-pery J, Raiskup F, Ilsar M, Landau D, Orucov F, Solomon A (2006) Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. Am J Ophthalmol 141(6):1044–1050

    Article  CAS  PubMed  Google Scholar 

  25. Mahar PS (1997) Conjunctival autograft versus topical mitomycin C in treatment of pterygium. Eye 11:790–792

    Article  PubMed  Google Scholar 

  26. Chen PP, Ariyasu RG, Kaza V, LaBree LD, McDonnell PJ (1995) A randomized trial comparing mitomycin C and conjunctival autograft after excision of primary pterygium. Am J Ophthalmol 120(2):151–160

    CAS  PubMed  Google Scholar 

  27. Mastropasqua L, Carpineto P, Ciancaglini M et al (1996) Long term results of intraoperative mitomycin C in the treatment of recurrent pterygium. Br J Ophthalmol 80:288–291

    Article  CAS  PubMed  Google Scholar 

  28. Mahar PS (1996) Role of mitomycin-C in reducing the recurrence of pterygium after surgery. Pak J Ophthalmol 12(3):91–94

    Google Scholar 

  29. Díaz L, Villegas VM, Emanuelli A, Izquierdo NJ (2008) Efficacy and safety of intraoperative mitomycin C as adjunct therapy for pterygium surgery. Cornea 27(10):1119–1121

    Article  PubMed  Google Scholar 

  30. Tan DTH, Chee SP, Dear KBG et al (1997) Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision. Arch Ophthalmol 115:1235–1240

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors are greatly indebted to Dr. Tashfeen Ahmad, Associate Professor, Department of Surgery, AKUH for his assistance in statistical analysis.

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Correspondence to Nabeel Manzar.

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Mahar, P.S., Manzar, N. The study of etiological and demographic characteristics of pterygium recurrence: a consecutive case series study from Pakistan. Int Ophthalmol 34, 69–74 (2014). https://doi.org/10.1007/s10792-013-9797-4

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  • DOI: https://doi.org/10.1007/s10792-013-9797-4

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