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Topiramate-induced angle-closure glaucoma: cross-sensitivity with other sulphonamide derivatives causing anterior uveitis

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Abstract

Topiramate is a recognized cause of drug-induced acute angle-closure glaucoma. We describe a case presenting with bilateral acute angle-closure glaucoma caused by topiramate intake. Patient subsequently developed severe anterior uveitis caused by sulphonamide derivatives (acetazolamide and co-trimoxazole) due to cross-sensitivity, on two separate occasions. The present case also highlights the role of anterior segment optical tomography in diagnosis and follow-up. In a patient with known drug allergy to topiramate, other sulphonamide derivatives should be avoided to limit the ocular morbidity.

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Authors and Affiliations

  1. Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, 110002, India

    Saurabh Kamal, Usha Yadava, Sushil Kumar & Ruchi Goel

  2. 2180, Sector 28, Faridabad, 121008, Haryana, India

    Saurabh Kamal

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  1. Saurabh Kamal
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  2. Usha Yadava
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  3. Sushil Kumar
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  4. Ruchi Goel
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Correspondence to Saurabh Kamal.

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Kamal, S., Yadava, U., Kumar, S. et al. Topiramate-induced angle-closure glaucoma: cross-sensitivity with other sulphonamide derivatives causing anterior uveitis. Int Ophthalmol 34, 345–349 (2014). https://doi.org/10.1007/s10792-013-9793-8

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  • DOI: https://doi.org/10.1007/s10792-013-9793-8

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