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Association of dehydroepiandrosterone sulfate, serum lipids, C-reactive protein and body mass index with age-related macular degeneration

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Abstract

The present study was designed to evaluate the associations between exudative age-related macular degeneration (AMD) and the serum concentrations of C-reactive protein (CRP), dehydroepiandrosterone sulfate (DHEAS), and lipids as well as the relationship between exudative AMD and body mass index (BMI). This cross-sectional study included of 141 healthy control subjects (70 males and 71 females with a mean age of 71.01 ± 3.84 years) and 142 exudative AMD patients (70 males and 72 females with a mean age of 70.92 ± 3.60 years). BMI and the serum concentrations of CRP, DHEAS, and lipids were measured in both groups. The data were statistically analysed using the Mann–Whitney U test, Chi squared test, independent sample t test, Cramer’s V, point biserial correlation and logistic regression analysis. BMI values and serum concentrations of CRP, total cholesterol, and low-density lipoprotein (LDL) cholesterol were significantly higher in exudative AMD patients compared with normal controls (p values were 0.001, <0.001, 0.005 and <0.001, respectively). The serum concentrations of DHEAS were not significantly different between the controls and the exudative AMD patients for the subgroups of either gender (p values in males and females were 0.785 and 0.159, respectively). A logistic regression analysis revealed that the BMI and serum concentration of CRP moderately contributed to the predictive ability of the model (odds ratios were 1.205 and 1.179, respectively). Elevated total cholesterol concentrations and LDL cholesterol concentrations, BMI values and serum concentrations of CRP were associated with exudative AMD. However, no association between the serum DHEAS concentration and exudative AMD was established.

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References

  1. Nowak JZ (2006) Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacol Rep 58(3):353–363

    PubMed  CAS  Google Scholar 

  2. Tsimikas S, Willerson JT, Ridker PM (2006) C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 47(8 Suppl):C19–C31

    Article  PubMed  CAS  Google Scholar 

  3. Seddon JM, George S, Rosner B, Rifai N (2005) Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. Arch Ophthalmol 123(6):774–782

    Article  PubMed  Google Scholar 

  4. Auchus RJ (2004) Overview of dehydroepiandrosterone biosynthesis. Semin Reprod Med 22(4):281–288

    Article  PubMed  CAS  Google Scholar 

  5. Altman R, Motton DD, Kota RS, Rutledge JC (2008) Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB. Vasc Pharmacol 48(2–3):76–84

    Article  CAS  Google Scholar 

  6. Bastianetto S, Ramassamy C, Poirier J, Quirion R (1999) Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Brain Res Mol Brain Res 66(1–2):35–41

    Article  PubMed  CAS  Google Scholar 

  7. Legrain S, Girard L (2003) Pharmacology and therapeutic effects of dehydroepiandrosterone in older subjects. Drugs Aging 20(13):949–967

    Article  PubMed  CAS  Google Scholar 

  8. Tamer C, Oksuz H, Sogut S (2007) Serum dehydroepiandrosterone sulphate level in age-related macular degeneration. Am J Ophthalmol 143(2):212–216

    Article  PubMed  CAS  Google Scholar 

  9. Saggini A, Anogeianaki A, Maccauro G, Tete S, Salini V, Caraffa A, Conti F, Fulcheri M, Galzio R, Shaik-Dasthagirisaheb YB (2011) Cholesterol, cytokines and diseases. Int J Immunopathol Pharmacol 24(3):567–581

    PubMed  CAS  Google Scholar 

  10. Dasari B, Prasanthi JR, Marwarha G, Singh BB, Ghribi O (2011) Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. BMC Ophthalmol 11:22

    Article  PubMed  CAS  Google Scholar 

  11. Najafi M, Roustazadeh A, Alipoor B (2011) Ox-LDL Particles: Modified components, Cellular uptake, Biological roles and Clinical assessments. Cardiovasc Hematol Disord Drug Targets

  12. Seddon JM, Reynolds R, Rosner B (2010) Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. Mol Vis 16:2412–2424

    PubMed  CAS  Google Scholar 

  13. Anderson DH, Mullins RF, Hageman GS, Johnson LV (2002) A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 134(3):411–431

    Article  PubMed  CAS  Google Scholar 

  14. Du Clos TW (2000) Function of C-reactive protein. Ann Med 32(4):274–278

    Article  PubMed  Google Scholar 

  15. Seddon JM, Gensler G, Milton RC, Klein ML, Rifai N (2004) Association between C-reactive protein and age-related macular degeneration. JAMA 291(6):704–710

    Article  PubMed  CAS  Google Scholar 

  16. Kim IK, Ji F, Morrison MA, Adams S, Zhang Q, Lane AM, Capone A, Dryja TP, Ott J, Miller JW, DeAngelis MM (2008) Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration. Mol Vis 14:1487–1495

    PubMed  CAS  Google Scholar 

  17. Klein R, Klein BE, Knudtson MD, Wong TY, Shankar A, Tsai MY (2005) Systemic markers of inflammation, endothelial dysfunction, and age-related maculopathy. Am J Ophthalmol 140(1):35–44

    PubMed  CAS  Google Scholar 

  18. McGwin G, Hall TA, Xie A, Owsley C (2005) The relation between C reactive protein and age related macular degeneration in the Cardiovascular Health Study. Br J Ophthalmol 89(9):1166–1170

    Article  PubMed  CAS  Google Scholar 

  19. Pepys MB, Hirschfield GM (2003) C-reactive protein: a critical update. J Clin Investig 111(12):1805–1812

    PubMed  CAS  Google Scholar 

  20. van Leeuwen R, Ikram MK, Vingerling JR, Witteman JC, Hofman A, de Jong PT (2003) Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci 44(9):3771–3777

    Article  PubMed  Google Scholar 

  21. Gutierrez G, Mendoza C, Zapata E, Montiel A, Reyes E, Montano LF, Lopez-Marure R (2007) Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells. Atherosclerosis 190(1):90–99

    Article  PubMed  CAS  Google Scholar 

  22. Bucolo C, Drago F, Lin LR, Reddy VN (2005) Neuroactive steroids protect retinal pigment epithelium against oxidative stress. NeuroReport 16(11):1203–1207

    Article  PubMed  CAS  Google Scholar 

  23. Defay R, Pinchinat S, Lumbroso S, Sutan C, Delcourt C (2004) Sex steroids and age-related macular degeneration in older French women: the POLA study. Ann Epidemiol 14(3):202–208. doi:10.1016/S1047-2797(03)00130-3

    Article  PubMed  Google Scholar 

  24. Reynolds R, Rosner B, Seddon JM (2010) Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration. Ophthalmology 117(10):1989–1995

    Article  PubMed  Google Scholar 

  25. Klein R, Cruickshanks KJ, Nash SD, Krantz EM, Javier Nieto F, Huang GH, Pankow JS, Klein BE (2010) The prevalence of age-related macular degeneration and associated risk factors. Arch Ophthalmol 128(6):750–758

    Article  PubMed  CAS  Google Scholar 

  26. Chakravarthy U, Wong TY, Fletcher A, Piault E, Evans C, Zlateva G, Buggage R, Pleil A, Mitchell P (2010) Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol 10:31

    Article  PubMed  Google Scholar 

  27. Moeini HA, Masoudpour H, Ghanbari H (2005) A study of the relation between body mass index and the incidence of age related macular degeneration. Br J Ophthalmol 89(8):964–966

    Article  PubMed  CAS  Google Scholar 

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None of the authors has conflict of interest with the submission.

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Authors and Affiliations

  1. Department of Ophthalmology, Abant Izzet Baysal University of Medicine, 14280, Bolu, Turkey

    Fatih Ulaş, Sedat Özmen, Serdal Çelebi & Ümit Doğan

  2. Malatya State Hospital, Ophthalmology Clinic, Malatya, Turkey

    Fatih Ulaş

  3. Malatya EGM Hayat Hospital, Ophthalmology Clinic, Malatya, Turkey

    Mehmet Balbaba

  4. Suluova State Hospital, Ophthalmology Clinic, Amasya, Turkey

    Sedat Özmen

Authors
  1. Fatih Ulaş
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  2. Mehmet Balbaba
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  3. Sedat Özmen
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  4. Serdal Çelebi
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  5. Ümit Doğan
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Correspondence to Fatih Ulaş.

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Ulaş, F., Balbaba, M., Özmen, S. et al. Association of dehydroepiandrosterone sulfate, serum lipids, C-reactive protein and body mass index with age-related macular degeneration. Int Ophthalmol 33, 485–491 (2013). https://doi.org/10.1007/s10792-013-9728-4

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  • DOI: https://doi.org/10.1007/s10792-013-9728-4

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