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Retinal nerve fiber layer and ganglion cell layer thickness in patients receiving systemic isotretinoin therapy

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Abstract

To evaluate the effect of oral isotretinoin therapy on retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness by spectral domain optical coherence tomography (OCT). This prospective study included newly diagnosed nodulocystic acne patients about to receive isotretinoin treatment. Macular average GCL thickness and peripapillary average, temporal, nasal, inferior, and superior quadrant RNFL thickness were measured by OCT before and after isotretinoin treatment. Pre- and post-treatment measurements were compared with paired t test. Fifty-six eyes of 28 patients were included. The mean duration of the treatment was 6.5 ± 1.3 months. The mean average GCL thickness was 90.04 ± 5.87 (80–96) μm at baseline and 90.75 ± 6.34 (81–96) μm after treatment. The mean average RNFL thickness was 93.25 ± 6.06 μm (84–107) before treatment and 93.05 ± 5.54 μm (82–106) after treatment. There were no statistically significant differences between pre- and post-treatment values (all p > 0.05). A 6-month course of systemic isotretinoin therapy seems to have no unfavorable effect on retinal ganglion cells; however, larger studies with longer follow-up periods are needed to be conclusive.

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References

  1. Ellis CN, Krach KJ (2001) Uses and complications of isotretinoin therapy. J Am Acad Dermatol 45:S150–S157

    Article  PubMed  CAS  Google Scholar 

  2. Santaella RM, Fraunfelder FW (2007) Ocular adverse effects associated with systemic medications: recognition and management. Drugs 67:75–93

    Article  PubMed  CAS  Google Scholar 

  3. Fraunfelder FT, Fraunfelder FW, Edwards R (2001) Ocular side effects possibly associated with isotretinoin usage. Am J Ophthalmol 132:299–305

    Article  PubMed  CAS  Google Scholar 

  4. Moseng L, Sæter M, Mørch-Johnsen GH, Hoff JM, Gajda A, Brodtkorb E, Midelfart A (2011) Retinal nerve fibre layer attenuation: clinical indicator for vigabatrin toxicity. Acta Ophthalmol 89:452–458

    Article  PubMed  Google Scholar 

  5. Pasadhika S, Fishman GA (2010) Effects of chronic exposure to hydroxychloroquine or chloroquine on inner retinal structures. Eye (Lond) 24:340–346

    Article  CAS  Google Scholar 

  6. Aydogan K, Turan OF, Onart S, Yazici B, Karadogan SK, Tokgoz N (2008) Neurological and neurophysiological effects of oral isotretinoin: a prospective investigation using auditory and visual evoked potentials. Eur J Dermatol 18:642–646

    PubMed  CAS  Google Scholar 

  7. McCaffery P, Dräger UC (2000) Regulation of retinoic acid signaling in the embryonic nervous system: a master differentiation factor. Cytokine Growth Factor Rev 11:233–249

    Article  PubMed  CAS  Google Scholar 

  8. Cheng AL, Chuang SE, Su IJ (1997) Factors associated with the therapeutic efficacy of retinoic acids on malignant lymphoma. J Formos Med Assoc 96:525–534

    PubMed  CAS  Google Scholar 

  9. Grünwald F, Menzel C, Bender H, Palmedo H, Otte R, Fimmers R, Risse J, Biersack HJ (1998) Redifferentiation therapy-induced radioiodine uptake in thyroid cancer. J Nucl Med 39:1903–1906

    PubMed  Google Scholar 

  10. Moriguchi S, Jackson JC, Watson RR (1985) Effects of retinoids on human lymphocyte functions in vitro. Hum Toxicol 4:365–378

    Article  PubMed  CAS  Google Scholar 

  11. Aydogan K, Karli N (2007) Effects of oral isotretinoin therapy on peripheral nerve functions: a preliminary study. Clin Exp Dermatol 32:81–84

    PubMed  CAS  Google Scholar 

  12. Chroni E, Pasmatzi E, Monastirli A, Georgiou S, Katsoulas G, Polychronopoulos P, Tsambaos D (2006) Short-term oral isotretinoin therapy does not cause clinical or subclinical peripheral neuropathy. J Dermatol Treat 17:6–8

    Article  CAS  Google Scholar 

  13. Kanamori A, Nakamura M, Escano MF, Seya R, Maeda H, Negi A (2003) Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography. Am J Ophthalmol 135:513–520

    Article  PubMed  Google Scholar 

  14. Bowd C, Zangwill LM, Berry CC, Blumenthal EZ, Vasile C, Sanchez-Galeana C, Bosworth CF, Sample PA, Weinreb RN (2001) Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function. Invest Ophthalmol Vis Sci 42:1993–2003

    PubMed  CAS  Google Scholar 

  15. Medeiros FA, Moura FC, Vessani RM, Susanna R Jr (2003) Axonal loss after traumatic optic neuropathy documented by optical coherence tomography. Am J Ophthalmol 135:406–408

    Article  PubMed  Google Scholar 

  16. Monteiro ML, Leal BC, Rosa AA, Bronstein MD (2004) Optical coherence tomography analysis of axonal loss in band atrophy of the optic nerve. Br J Ophthalmol 88:896–899

    Article  PubMed  CAS  Google Scholar 

  17. Trip SA, Schlottmann PG, Jones SJ, Altmann DR, Garway-Health DF, Thompson AJ, Plant GT, Miller DH (2005) Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol 58:383–391

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Recep Tayyip Erdogan University Medical School, Rize, Turkey

    Berrak Sekeryapan, Veysi Oner, Kemal Turkyılmaz & Mehmet Gokhan Aslan

  2. Department of Dermatology, Recep Tayyip Erdogan University Medical School, Rize, Turkey

    Nursel Dılek

  3. Fener Mah, Yesilkent Apt. No:12, 53100, Rize, Turkey

    Berrak Sekeryapan

Authors
  1. Berrak Sekeryapan
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  2. Nursel Dılek
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  3. Veysi Oner
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  4. Kemal Turkyılmaz
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  5. Mehmet Gokhan Aslan
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Correspondence to Berrak Sekeryapan.

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None of the authors has financial interest or research funding.

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Sekeryapan, B., Dılek, N., Oner, V. et al. Retinal nerve fiber layer and ganglion cell layer thickness in patients receiving systemic isotretinoin therapy. Int Ophthalmol 33, 481–484 (2013). https://doi.org/10.1007/s10792-013-9726-6

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  • DOI: https://doi.org/10.1007/s10792-013-9726-6

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