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Effect of intracameral carbachol given during cataract surgery on macular thickness

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Abstract

To evaluate the effect of intracameral carbachol on foveal thickness in patients who underwent uneventful cataract surgery. This retrospective study included two groups: the study group patients (group 1, n = 47 eyes) had uneventful cataract surgery and received only carbachol 0.01 % for miosis; the control group patients (group 2, n = 49 eyes) had uneventful cataract surgery without carbachol or any intracameral medication(s). The groups were compared for foveal thickness after cataract surgery. All phacoemulsification plus intraocular lens implantation surgeries were performed under local anesthesia via temporal clear corneal tunnel incisions. Mean values and standard deviations were calculated for preoperative and postoperative visual acuity (VA) and foveal thickness (FT) at 1 and 4 weeks. Optical coherence tomography was used for the FT measurements, with the MM6 map program. The patients in the study and control groups had a mean age of 57.78 ± 9.07 and 59.72 ± 8.96, respectively (p = 0.355). All eyes had a significant improvement in VA. In the study group, the mean FT at the visits before and 1 and 4 weeks after surgery was 216.87 ± 21.06, 228.81 ± 30.52, and 222.94 ± 29.91 μm, respectively. For the control group, the mean FT, before and 1 and 4 weeks after surgery, was 222.53 ± 17.66, 231.67 ± 23.08, and 225.41 ± 22.59 μm, respectively. Intracameral carbachol 0.01 % had no effect on foveal thickness in patients who underwent uneventful cataract surgery.

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References

  1. Wedrich A, Menapace R (1992) Effect of carbachol on intraocular pressure in small-incision cataract surgery. Doc Ophthalmol 80:301–307

    Article  PubMed  CAS  Google Scholar 

  2. Ruiz RS, Rhem MN, Prager TC (1989) Effects of carbachol and acetylcholine on intraocular pressure after cataract extraction. Am J Ophthalmol 107:7–10

    PubMed  CAS  Google Scholar 

  3. Cekic O, Batman C (1999) Effect of intracameral carbachol on intraocular pressure following clear corneal phacoemulsification. Eye (London) 13:209–211

    Article  Google Scholar 

  4. Phillipall B, Crandall AS, Mamalis N, Olson RJ (1997) Intraoperative miotics and posterior capsular opacification following phacoemulsification with intraocular lens insertion. Ophthalmic Surg Lasers 28:911–914

    Google Scholar 

  5. Myers WG, Edelhauser HF (2011) Shortage of bisulfite-free preservative-free epinephrine for intracameral use. J Cataract Refract Surg 37:611

    Article  PubMed  Google Scholar 

  6. Mori Y, Miyai T, Kagaya F, Nagai N, Osakabe Y, Miyata K, Amano S (2011) Intraoperative mydriasis by intracameral injection of mydriatic eye drops: in vivo efficacy and in vitro safety studies. Clin Exp Ophthalmol 39:456–461

    Article  Google Scholar 

  7. Qureshi F, Clark D (2011) Macular infarction after inadvertent intracameral cefuroxime. J Cataract Refract Surg 37:1168–1169

    Article  PubMed  Google Scholar 

  8. Delyfer MN, Rougier MB, Leoni S, Zhang Q, Dalbon F, Colin J, Korobelnik JF (2011) Ocular toxicity after intracameral injection of very high doses of cefuroxime during cataract surgery. J Cataract Refract Surg 37:271–278

    Article  PubMed  Google Scholar 

  9. Tan CS, Fam HB, Heng WJ, Lee HM, Saw SM, Au Eong KG (2011) Analgesic effect of supplemental intracameral lidocaine during phacoemulsification under topical anaesthesia: a randomised controlled trial. Br J Ophthalmol 95:837–841

    Article  PubMed  Google Scholar 

  10. Kim EC, Park SH, Kim MS (2010) A comparison of pupil dilation and induction of corneal endothelial apoptosis by intracameral 1 % lidocaine versus 1:100,000 epinephrine in rabbits. J Ocul Pharmacol Ther 26:563–570

    Article  PubMed  CAS  Google Scholar 

  11. Praveen MR, Shah SK, Vasavada VA, Dixit NV, Vasavada AR, Garg VS, Trivedi RH (2010) Triamcinolone-assisted vitrectomy in pediatric cataract surgery: intraoperative effectiveness and postoperative outcome. J AAPOS 14:340–344

    Article  PubMed  Google Scholar 

  12. Cleary CA, Lanigan B, O’Keeffe M (2010) Intracameral triamcinolone acetonide after pediatric cataract surgery. J Cataract Refract Surg 36:1676–1681

    Article  PubMed  Google Scholar 

  13. Behndig A, Lundberg B (2010) Mydriatic response to different concentrations of intracameral phenylephrine in humans. J Cataract Refract Surg 36:1682–1686

    Article  PubMed  Google Scholar 

  14. Johansson M, Lundberg B, Behndig A (2007) Optical coherence tomography evaluation of macular edema after phacoemulsification surgery with intracameral mydriatics. J Cataract Refract Surg 33:1436–1441

    Article  PubMed  Google Scholar 

  15. Lane SS, Osher RH, Masket S, Belani S (2008) Evaluation of the safety of prophylactic intracameral moxifloxacin in cataract surgery. J Cataract Refract Surg 34:1451–1459

    Article  PubMed  Google Scholar 

  16. Lam PT, Young AL, Cheng LL, Tam PM, Lee VY (2010) Randomized controlled trial on the safety of intracameral cephalosporins in cataract surgery. Clin Ophthalmol 4:1499–1504

    PubMed  CAS  Google Scholar 

  17. Ball JL, Barrett GD (2006) Prospective randomized controlled trial of the effect of intracameral vancomycin and gentamicin on macular retinal thickness and visual function following cataract surgery. J Cataract Refract Surg 32:789–794

    Article  PubMed  Google Scholar 

  18. Horozoglu F, Yanyali A, Aytug B, Nohutcu AF, Keskinbora KH (2011) Macular thickness changes after phacoemulsification in previous vitrectomized eyes for diabetic macular edema. Retina 31:1095–1100

    Article  PubMed  Google Scholar 

  19. Chaudhry P, Prakash G, Jacob S, Narasimhan S, Agarwal S, Agarwal A (2010) Safety and efficacy of gas forced infusion (air pump) in coaxial phacoemulsification. J Cataract Refract Surg 36:2139–2145

    Article  PubMed  Google Scholar 

  20. Ghosh S, Roy I, Biswas PN, Maji D, Mondal LK, Mukhopadhyay S, Bhaduri G (2010) Prospective randomized comparative study of macular thickness following phacoemulsification and manual small incision cataract surgery. Acta Ophthalmol 88:102–106

    Article  Google Scholar 

  21. Cagini C, Fiore T, Iaccheri B, Piccinelli F, Ricci MA, Fruttini D (2009) Macular thickness measured by optical coherence tomography in healthy population before and after uncomplicated cataract phacoemulsifcation surgery. Curr Eye Res 34:1036–1041

    Article  PubMed  Google Scholar 

  22. Yazici AT, Bozkurt E, Altan CD, Albayrak S, Cakir M, Alagoz N, Yılmaz OF (2010) Macular thickness changes after phacoemulsisifcation combined with primary posterior curvilinear capsulorhexis. Eur J Ophthalmol 20:376–380

    PubMed  Google Scholar 

  23. Randazzo A, Vinciguerra P (2010) Chronic macular edema medical treatment in Irvine-Gass syndrome: case report. Eur J Ophthalmol 20:462–465

    PubMed  Google Scholar 

  24. Sourdille P, Santiago P-Y (1999) Optical coherence tomography of macular thickness after cataract surgery. J Cataract Refract Surg 25:256–261

    Article  PubMed  CAS  Google Scholar 

  25. Ching HY, Wong AC, Wong CC, Woo DC, Chan CW (2006) Cystoid macular oedema and changes in retinal thickness after phacoemulsification with optical coherence tomography. Eye 20:297–303

    Article  PubMed  Google Scholar 

  26. Biro Z, Balla Z, Kovacs B (2008) Change of foveal and perifoveal thickness measured by OCT after phacoemulsification and IOL implantation. Eye (London) 22:8–12

    Article  CAS  Google Scholar 

  27. Kurz S, Krummenauer F, Thiema H, Dick HB (2009) Optical coherence tomography of macular thickness after biaxial vs coaxial microincision clear corneal cataract surgery. Eur J Ophthalmol 19:990–997

    PubMed  Google Scholar 

  28. Kim SJ, Belair ML, Bressler NM, Dunn JP, Thorne JE, Kedhar SR, Jabs DA (2008) A method of reporting macular edema after cataract surgery using optical coherence tomography. Retina 28:870–876

    Article  PubMed  Google Scholar 

  29. von Jagow B, Ohrloff C, Kohnen T (2007) Macular thickness after uneventful cataract surgery determined by optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 245:1765–1771

    Article  Google Scholar 

  30. Biro Z, Balla Z, Kovacs B (2008) Change of foveal and perifoveal thickness measured by OCT after phacoemulsification and IOL implantation. Eye (London) 22:8–12

    Article  CAS  Google Scholar 

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Correspondence to Mehmet Demir.

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Demir, M., Oba, E., Dirim, B. et al. Effect of intracameral carbachol given during cataract surgery on macular thickness. Int Ophthalmol 32, 413–416 (2012). https://doi.org/10.1007/s10792-012-9579-4

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  • DOI: https://doi.org/10.1007/s10792-012-9579-4

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