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Relationship of central corneal thickness to postural IOP changes in patients with and without glaucoma in southern India

International Ophthalmology volume 32, pages 307–311 (2012)Cite this article

Abstract

To evaluate the relationship of central corneal thickness to the changes in intraocular pressure (IOP) in the sitting and supine position. Observational case–control study. The study group included Primary open-angle and chronic angle closure glaucoma patients. The control group consisted of patients without glaucoma seen for their routine eye examination. Central corneal thickness was measured by ultrasound pachymetry. Patients were then randomized to IOP measurement by Tonopen either sitting or supine after maintaining that position for 5 min. The position was then reversed and IOP measurements taken again after 5 min. Main outcome measure was change in IOP. One hundred and eighty-two eyes (90 in cases and 92 in controls) were examined. The mean CCT was 538.11 ± 37.17 μm in the study group and 545.34 ± 36.01 μm in the control group (P = 0.185). The mean IOP in the sitting position was 19.54 ± 5.39 mmHg in cases and 14.82 ± 4.01 in controls (P < 0.001). The mean IOP in the supine position was 20.51 ± 5.48 mmHg in cases and 16.02 ± 3.24 in controls (P < 0.001). Mean IOP change from sitting to supine was statistically significant in both groups (P < 0.001 for both). Postural change was greater in cases than controls (P = 0.020). There was no correlation between postural IOP change and CCT in cases (r = 0.143, P = 0.180) and controls (r = 0.096, P = 0.362). Postural IOP change is greater in glaucoma patients than non-glaucomatous patients. There was no correlation between postural IOP change and CCT.

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References

  1. Brandt JD (2007) Central corneal thickness, tonometry, and glaucoma risk—a guide for the perplexed. Can J Ophthalmol 42:562–566

    PubMed  Article  Google Scholar 

  2. Harada Y, Hirose N, Kubota T, Tawara A (2008) The influence of central corneal thickness and corneal curvature radius on the intraocular pressure as measured by different tonometers: non-contact and goldmann applanation tonometers. J Glaucoma 17:619–625

    PubMed  Article  Google Scholar 

  3. Dohadwala AA, Munger R, Damji KF (1998) Positive correlation between Tono-Pen intraocular pressure and central corneal thickness. Ophthalmology 105:1849–1854

    PubMed  Article  CAS  Google Scholar 

  4. Tonnu PA, Ho T, Newson T, El Sheikh A et al (2005) The influence of central corneal thickness and age on intraocular pressure measured by pneumotonometry, non-contact tonometry, the Tono-Pen XL, and Goldmann applanation tonometry. Br J Ophthalmol 89:851–854

    PubMed  Article  Google Scholar 

  5. Hong S, Kim CY, Seong GJ, Hong YJ (2007) Central corneal thickness and visual field progression in patients with chronic primary angle-closure glaucoma with low intraocular pressure. Am J Ophthalmol 143:362–363

    PubMed  Article  Google Scholar 

  6. Pfeiffer N, Torri V, Miglior S, European Glaucoma Prevention Study Group et al (2007) Central corneal thickness in the European Glaucoma Prevention Study. Ophthalmology 114:454–459

    PubMed  Article  Google Scholar 

  7. Liu JH, Zhang X, Kripke DF, Weinreb RN (2003) Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes. Invest Ophthalmol Vis Sci 44:1586–1590

    PubMed  Article  Google Scholar 

  8. Kiuchi T, Motoyama Y, Oshika T (2006) Relationship of progression of visual field damage to postural changes in intraocular pressure in patients with normal-tension glaucoma. Ophthalmology 113:2150–2155

    PubMed  Article  Google Scholar 

  9. Mosaed S, Chamberlain WD, Liu JH et al (2008) Association of central corneal thickness and 24-hour intraocular pressure fluctuation. J Glaucoma 17:85–88

    PubMed  Article  Google Scholar 

  10. Jain MR, Marmion VJ (1976) Rapid pneumatic and Mackey–Marg applanation tonometry to evaluate the postural effect on intraocular pressure. Br J Ophthalmol 60:687–693

    PubMed  Article  CAS  Google Scholar 

  11. Hewitt AW, Cooper RL (2005) Relationship between corneal thickness and optic disc damage in glaucoma. Clin Exp Ophthalmol 33:158–163

    Article  Google Scholar 

  12. Gordon MO, Beiser JA, Brandt JD et al (2002) The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 120:714–720

    PubMed  Article  Google Scholar 

  13. Hirooka K, Shiraga F (2003) Relationship between postural change of the intraocular pressure and visual field loss in primary open-angle glaucoma. J Glaucoma 12:379–382

    PubMed  Article  Google Scholar 

  14. Kiuchi T, Motoyama Y, Oshika T (2010) Postural response of intraocular pressure and visual field damage in patients with untreated normal-tension glaucoma. J Glaucoma 19:191–193

    PubMed  Article  Google Scholar 

  15. Wozniak K, Köller AU, Spörl E et al (2006) Intraocular pressure measurement during the day and night for glaucoma patients and normal controls using Goldmann and Perkins applanation tonometry. Ophthalmologe 103:1027–1031

    PubMed  Article  CAS  Google Scholar 

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The authors have no financial interest in the subject matter of this paper.

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Affiliations

  1. Aravind Eye Hospital, Pondicherry, Tamil Nadu, India

    Stephen J. Moster, Rengaraj Venketesh & Marlene R. Moster

  2. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Ghasem Fakhraie

  3. William and Anna Goldberg Glaucoma Service, Wills Eye Hospital, Jefferson Medical College, 840 Walnut Street, Philadelphia, PA, 19107, USA

    Ghasem Fakhraie, Mark L. Moster, Yuanjun Zhao & Marlene R. Moster

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  1. Stephen J. Moster
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  2. Ghasem Fakhraie
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  3. Rengaraj Venketesh
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  4. Mark L. Moster
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  6. Marlene R. Moster
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Correspondence to Ghasem Fakhraie.

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Moster, S.J., Fakhraie, G., Venketesh, R. et al. Relationship of central corneal thickness to postural IOP changes in patients with and without glaucoma in southern India. Int Ophthalmol 32, 307–311 (2012). https://doi.org/10.1007/s10792-012-9522-8

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  • DOI: https://doi.org/10.1007/s10792-012-9522-8

Keywords

  • Intra-ocular pressure
  • Central corneal thickness
  • Postural change