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Role of intravitreal bevacizumab in adult onset Coats’ disease

International Ophthalmology volume 31, pages 183–190 (2011)Cite this article

Abstract

To evaluate the role of intravitreal bevacizumab in the treatment of Coats’ disease diagnosed in adulthood. Prospective, interventional case series. Three patients with Coats’ disease diagnosed in adulthood were managed with a single intravitreal injection of bevacizumab (1.25 mg) with peripheral laser photocoagulation 3 weeks later. All three patients had exudation at the macula (Stage 2B) along with peripheral retinal telangiectasia and aneurysms. They were followed up for 9 months. An appreciable reduction in the exudation at the macula and macular edema was observed in all cases following intravitreal bevacizumab therapy. In all patients, the visual acuity improved, and no signs of recurrence were observed at the final follow-up at 9 months. Intravitreal bevacizumab injections may be effective as an adjunctive treatment for adult-onset Coats’ disease with foveal exudation along with laser photocoagulation to the peripheral retinal vascular abnormalities. Intravitreal bevacizumab was well tolerated by our patients, and no adverse effects were observed.

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Affiliations

  1. Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India

    Neha Goel, Anisha Seth, Usha Kaul Raina & Basudeb Ghosh

  2. Department of Ophthalmology, University College of Medical Sciences and GTB Hospital, Delhi, India

    Vinod Kumar

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  1. Neha Goel
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  2. Vinod Kumar
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  3. Anisha Seth
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  4. Usha Kaul Raina
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  5. Basudeb Ghosh
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Correspondence to Neha Goel.

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Goel, N., Kumar, V., Seth, A. et al. Role of intravitreal bevacizumab in adult onset Coats’ disease. Int Ophthalmol 31, 183–190 (2011). https://doi.org/10.1007/s10792-011-9436-x

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  • DOI: https://doi.org/10.1007/s10792-011-9436-x

Keywords

  • Intravitreal bevacizumab
  • Vascular endothelial growth factor
  • Adult onset Coats’ disease
  • Macular edema
  • Subfoveal exudation